Yang, S., Gu, C., Miao, X., Zuo, H., Xu, W., Zhang, Y., Tang, W., Zhu, J., Yuan, Z., Gu, X., Zhong, C., Sun, Y., Zhou, J.

Single-cell and spatial transcriptome profiling identifies the immunosuppressive spatial niche in KRAS-mutant colorectal cancer

31 de December de 2025 by Yang, S., Gu, C., Miao, X., Zuo, H., Xu, W., Zhang, Y., Tang, W., Zhu, J., Yuan, Z., Gu, X., Zhong, C., Sun, Y., Zhou, J.

Background
KRAS is one of the most frequently mutated genes in colorectal cancer (CRC) and plays a crucial role in tumorigenesis, progression, immune evasion, and treatment resistance. The pronounced heterogeneity within KRAS-mutant CRC highlights t…

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