Yang, S., Wang, W., Rao, Q., Xu, Y., Zhang, S., Qu, Y., Zhuang, Q., Mao, J., Sun, L., Geng, D., Xu, D., Zhao, C.

Mechanistic data-informed multiscale quantitative systems pharmacology modeling framework enables the clinical translation and efficacy assessment of CAR-T therapy in solid tumors

9 de October de 2025 by Yang, S., Wang, W., Rao, Q., Xu, Y., Zhang, S., Qu, Y., Zhuang, Q., Mao, J., Sun, L., Geng, D., Xu, D., Zhao, C.

Background
Chimeric antigen receptor (CAR)-T cell therapy represents an innovative and potentially revolutionary modality in cancer treatment. Despite their great success in treating blood cancers, CAR-T therapies exhibit significantly lower effective…