Yao, Y., Luo, Y., Wang, Z., Yin, E., Liu, C., Zheng, S., Wang, X., Tang, X., Sun, N., He, J.

Tumor-secreted AGR2 induces dendritic cell dysfunction and impairs immunotherapy efficacy in LKB1-deficient cancer

24 de October de 2025 by Yao, Y., Luo, Y., Wang, Z., Yin, E., Liu, C., Zheng, S., Wang, X., Tang, X., Sun, N., He, J.

Background
LKB1 (STK11)-deficient tumors exhibit an immunosuppressive microenvironment that limits the efficacy of immunotherapies such as anti-programmed cell death protein 1 (PD-1) antibodies. However, the underlying mechanisms driving immune evasio…