Zhan, X., Hu, H., Liu, Y., Wan, H., Zheng, F., Chen, L., Liu, X., Xiong, J., Cui, X., Xu, S., Fu, B.

TRIM28 drives immune evasion via PARP1 SUMOylation and NAD+ depletion in clear cell renal cell carcinoma

24 de October de 2025 by Zhan, X., Hu, H., Liu, Y., Wan, H., Zheng, F., Chen, L., Liu, X., Xiong, J., Cui, X., Xu, S., Fu, B.

Background
Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical potential in a variety of cancers; however, its efficacy in clear cell renal cell carcinoma (ccRCC) remains suboptimal. In ccRCC, an increased infiltration of CD…