Zhang, Z., Xie, Y.-A., Mu, C., Sheng, S., Zhang, J., Han, J., Li, J., He, Z., Liu, X.

Targeting TOMM40 unleashes immunogenic mitophagy to facilitate antigen presentation and immunotherapy sensitization

27 de July de 2026 by Zhang, Z., Xie, Y.-A., Mu, C., Sheng, S., Zhang, J., Han, J., Li, J., He, Z., Liu, X.

Background
Mitophagy is a mitochondrial quality control process that maintains cellular homeostasis in cancer, yet whether its dysregulation can be exploited to induce tumor immunogenicity remains unclear.

Methods
We integrated pancancer single-cell …