Zhao, Z., Cai, H., Nie, W., Wang, X., Zhao, Z., Zhao, F., Chen, Y., Luo, Z., Lin, Z., Lin, L., Ding, Y.

Ectopic expression of GDF15 in cancer-associated fibroblasts enhances melanoma immunosuppression via the GFRAL/RET cascade

25 de June de 2025 by Zhao, Z., Cai, H., Nie, W., Wang, X., Zhao, Z., Zhao, F., Chen, Y., Luo, Z., Lin, Z., Lin, L., Ding, Y.

Background
A key aspect of tumor biology is the involvement of cancer-associated fibroblasts (CAFs) in shaping the immunosuppressive microenvironment. However, the dynamic and complex key roles of CAFs in the melanoma immune microenvironment have not …