Zhu, W., Lu, S., Jia, L., Liu, B., Song, S., Bao, X., Yu, T., Zhang, Y., Miao, Z., He, J.

Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation

30 de May de 2025 by Zhu, W., Lu, S., Jia, L., Liu, B., Song, S., Bao, X., Yu, T., Zhang, Y., Miao, Z., He, J.

Backgroud: The E3 ubiquitin ligase casitas B lymphoma-b (Cbl-b) is pivotal in modulating immune responses by attenuating T-cell activation and cytokine production. Inhibiting Cbl-b presents a potential therapeutic strategy in immuno-oncology by enha…