Thymopoiesis plays a critical role in shaping the peripheral T-cell repertoire during childhood. Following pediatric liver transplantation, patients receive intensive immunosuppressive therapy, which may disrupt thymic function; however, thymic involve…
BackgroundEarly detection of hepatic involvement in common variable immunodeficiency (CVID) and agammaglobulinemia (AGA) remains hampered by the absence of validated non-invasive biomarkers. Although the Enhanced Liver Fibrosis (ELF) score is well esta…
BackgroundInducible nitric oxide synthase (iNOS) and its product nitric oxide (NO) were historically linked to poor melanoma outcomes, yet recent evidence shows NO supports anti-tumor immunity. This study examines how iNOS shapes anti–PD-1 efficacy, pa…
Orbital inflammation is the most common presentation of VEXAS, with any orbital structure potentially affected. Non-sight-threatening and uncomplicated anterior non-granulomatous uveitis and anterior diffuse scleritis follow in frequency, along with ep…
We conducted a retrospective review of adult kidney transplant recipients (KTRs) who received belatacept in addition to calcineurin inhibitors, antimetabolites, and corticosteroids for recurrent or refractory rejection or for persistent donor-specific …
Thrombotic microangiopathies (TMAs) encompass a spectrum of severe pathological conditions mostly characterized by hemolytic anemia, microvascular thrombosis with organ failure, and thrombocytopenia. The etiological spectrum of TMA is diverse, with a n…
BackgroundNeutrophils play an important role in the immune system by sensing environmental perturbations, including pathogens. Upon activation, neutrophils extrude their chromatin to form neutrophil extracellular traps (NETs), which trap and remove pat…
BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, they can trigger diverse immune-related adverse events (irAEs). Among these, ICI-related myocarditis, myositis and myasthenia gravis (MMM) overlap syndrome (ICI-M…
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown etiology associated with chronic severe fatigue and neurological symptoms, including dizziness, sleep disturbances, cognitive impairment and pain. There are no reliable…
Genome-wide association studies have linked CARS2 locus, encoding the mitochondrial cysteinyl aminoacyl-tRNA synthetase CARS2, to coronary artery disease. Moreover, we previously demonstrated that CARS2 suppression was associated with a pro-inflammator…
