BackgroundAtherosclerosis is a leading cause of cardiovascular disease (CVD), particularly in older individuals. We previously demonstrated that monocytes from older men with no self-reported history of CVD had a higher propensity to form foam cells ex…
Primary lymphatic anomalies (PLA) are disorders characterised by interstitial accumulation of lymph due to dysfunctional lymphatics. T cell lymphopenia occurs in these anomalies irrespective of cause, primarily affecting less-differentiated CD4+ popula…
ObjectivesTo describe Computed Tomography (CT) and laboratory findings in adult cases of abdominal immunoglobulin A vasculitis (IgAV), comparing patients who experienced cutaneous purpura before versus after gastrointestinal (GI) symptoms.MethodsWe ret…
Messenger RNA (mRNA) vaccines have emerged as a powerful vaccination platform, yet efficient and targeted delivery of mRNA to professional antigen-presenting cells (APCs) remains a major challenge. Here, we developed a dendritic cell (DC)-targeting vir…
The hepatocyte growth factor (HGF)-MET axis is a major oncogenic pathway, yet how it shapes cytotoxic T cell function remains unclear. Here, we show that MET identifies a transcriptionally and functionally distinct subset of tumor-reactive CD8+ T cells…
Algorithms that predict which peptides the immune system sees are central to cancer vaccine design, yet they are trained almost entirely on binding affinity and remain largely blind to how the antigen-processing machinery shapes the repertoire that rea…
BackgroundGermline GATA2 deficiency is a hereditary disorder characterized by immunodeficiency, bone marrow failure, and a high risk of myelodysplastic neoplasms and acute myeloid leukemia (AML). Although abnormalities of innate immunity are well recog…
T-cell immune dysregulation is common in end-stage renal disease (ESRD), but whether hemodialysis (HD) differentially affects T-cell immune activity remains unclear. We evaluated the peripheral T-cell immune characteristics of 96 patients with ESRD and…
BackgroundRespiratory syncytial virus (RSV) circulates as two antigenically distinct subgroups, RSV-A and RSV-B, frequently alternating in seasonal predominance. Whether RSV subgroup predominance affects neutralizing immunity and how population immunit…
A substantial proportion of patients with clinical primary immunodeficiencies remain without a definitive molecular diagnosis, and the functional consequences of identified variants are not always predictable from genotyping alone. Functional assays th…
