Complete complement Factor I (FI) deficiency is an ultra-rare inborn error of immunity characterized by invasive encapsulated bacterial infections and/or sterile neuroinflammation (DEFICIT syndrome). Acute episodes can progress rapidly to life-threaten…
Glioblastoma (GBM) contains spatially distinct vascular and hypoxia/necrosis-associated compartments, but the extent to which these classical anatomical regions share transcriptional programs linking vascular remodeling with immune-related processes re…
Introductionγδ T cells play a critical role in tissue immunosurveillance through their capacity to sense cellular stress. However, their recruitment dynamics to peripheral organs such as kidney during Shiga toxin (Stx)–induced renal damage, remain unde…
Functional competence in the adaptive immune system requires the generation of αβT-cells in the thymus, where thymic epithelial cells (TEC) drive thymocyte development. Roles for cortical thymic epithelial cells (cTEC) include the generation of CD4+CD8…
Humoral immunization to alloantigens on transfused red blood cells (RBCs) remains a major barrier to safe and effective blood transfusion in chronically transfused patients. However, only some patients become alloimmunized following multiple transfusio…
BackgroundHeterogeneous responses across disease sites may occur after systemic therapy for biliary tract cancer (BTC), but their pathological and immune features remain poorly characterized. We report a case with pathological complete response (pCR) a…
Immune involvement in psychosis is well supported, although most of the evidence comes from studies of negative and deficit symptoms. Grandiosity, in comparison, has received little attention. It is, however, the one symptom for which the two main acco…
IntroductionWe previously showed that human HMGB1 has anti-biofilm activity localized to a 97-amino-acid B-Box-derived peptide (mB Box-97), engineered with a C106S mutation to reduce HMGB1’s proinflammatory properties while retaining anti-biofilm funct…
Adoptive T-cell therapies using chimeric antigen receptors (CARs) or engineered T-cell receptors (TCRs) have transformed cancer treatment but remain limited by poor persistence and progressive T-cell exhaustion. Manufacturing strategies that promote me…
IntroductionAs an important cause of immune system dysfunction, stress can damage thymic stromal cells, leading to a persistent imbalance in thymic function. Thymic B cells can present autoantigens, playing a critical role in the establishment of centr…
