BackgroundCD36 deficiency is a genetic disorder that can lead to fetal/neonatal alloimmune thrombocytopenia or platelet transfusion refractoriness. While CD36 deficiency caused by exonic mutations are well established, the RNA splicing mechanism by int…
Colostrum is rich in macronutrients and bioactive components that support physiological adaptation during the neonatal period in ruminants. However, information on the early hematological, biochemical, and immunological changes to colostrum intake in b…
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a potential cure for malignant and non-malignant hematopoietic diseases, but the development of acute graft-versus-host disease (GvHD) caused by donor immune cell-mediated inflammation an…
IntroductionImmunotherapy has revolutionized cancer treatment with remarkable outcomes, expanding treatment options and enabling new surgical opportunities for patients with previously unresectable disease. This descriptive study examines the impact of…
BackgroundAntibody-dependent cellular cytotoxicity (ADCC) is a critical Fc-mediated immune mechanism contributing to antiviral defence. However, its functionality in people living with HIV (PLHIV) following SARS-CoV-2 exposure remains poorly understood…
Parkinson’s disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons accompanied by chronic neuroinflammation and α-SYNUCLEIN (α-SYN) aggregation. Increasing evidence suggests that cardiovascular comorbidities, in…
Inflammation is an important component of protective immunity in the lower female genital tract but must be tightly regulated to limit host tissue damage. In this study, we evaluated the in vivo potential of the anti-inflammatory drug Acetylsalicylic A…
IntroductionSome cerebral demyelinating lesions occur after vaccination. We aimed to elucidate the precise roles of vaccine-activated immune cells and antigen-specific lymphocytes in the central nervous system of a patient who developed cerebral demyel…
Respiratory infectious diseases remain a major global health burden, sustained by ongoing community transmission. Licensed respiratory vaccines are predominantly systemically administered, which elicit vaccine-induced antigen-specific circulating immun…
Metastatic recurrence is still a major problem for triple-negative breast cancer (TNBC). Neutrophil extracellular traps (NETs) in the pulmonary microenvironment are known to play key roles in the metastatic colonization and outgrowth of TNBC. However, …
