ObjectivesIncreased susceptibility to infections is observed in patients with thymomas. These have been invariably attributed to Good syndrome with hypogammaglobulinemia, but there is noticeable heterogeneity in clinical presentation. We clinically and…
BackgroundVitamin D is a pleiotropic steroid hormone with immunomodulatory properties. The role of the active metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)2 vitamin D), in regulating human T-cell effector function and immune checkpoint (IC) pathways …
The cGAS/STING pathway is a critical signaling hub that orchestrates type I interferon (IFN) responses, autophagy, and programmed cell death in response to double-stranded DNA (dsDNA) or cyclic dinucleotides. While traditionally characterized as a sens…
Group VIA calcium-independent phospholipaseA2 (iPLA2β or PLA2G6) is a homeostatic enzyme involved in basal glycerophospholipid metabolism. The mutations in the PLA2G6 gene lead to heterogenous neurodegenerative disorders. Global PLA2G6 inactivation in …
Post-herpetic neuralgia (PHN) is a chronic pain condition that persists after shingles and involves dermatome-specific allodynia, disability, and psychological comorbidities. Cutaneous neuroimmune dysregulation is increasingly linked to chronic pain, b…
IntroductionWith the widespread use of biologic agents in dermatology, immune drift has emerged as a growing clinical challenge. Although several case reports suggest the therapeutic potential of JAK inhibitors, clinical evidence for upadacitinib—a hig…
Invariant natural killer T (iNKT) cells play a role in preventing graft-versus-host disease (GVHD) in bone marrow transplantation (BMT), but it is not known whether and how the NKT10 and NKT17 subsets prevent GVHD. Here, we investigated the anti-GVH ef…
Background and objectivesSerum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) in neuromyelitis optica spectrum disorder (NMOSD) have recently emerged as potential biomarkers of disease activity, although their clinic…
IntroductionGlobally, 15-30% of patients with chronic hepatitis C develop compensated advanced chronic liver disease (cACLD). cACLD may further advance to decompensated ACLD (dACLD), which is associated with higher liver-related mortality, even after s…
Urinary tract infections (UTIs) are common and traditionally linked to bacteria; however, yeasts— particularly Trichosporon asahii — have emerged as opportunistic pathogens in immunocompromised and hospitalized patients. The presence of fungi may repre…
