BackgroundIschemic stroke thrombi contain complex immunothrombotic components, including neutrophil extracellular traps (NETs), which contribute to thrombus stability and resistance to fibrinolysis. However, the endogenous triggers of NETosis within st…
BackgroundImmune cells must adapt to highly variable oxygen levels encountered across different tissues of the body. Under inflammatory conditions, oxygen levels may reach further extremes, for example healthy synovial joints display oxygen levels of 6…
Myo-inositol (MI) plays an important role in intracellular signaling, cell proliferation, and cell growth, and has been associated with positive effects on the immune system and health in fish. However, its potential immunological effects in poultry ha…
Background/aimThe prognostic immune and nutritional index (PINI) has been increasingly recognized as a significant parameter associated with clinical outcomes in multiple cancers. Nevertheless, its prognostic role in esophageal squamous cell carcinoma …
Risk factors for relapse and non-relapse mortality (NRM) in the first years after allogeneic hematopoietic stem cells transplant (allo-HSCT) for acute myeloid leukemia (AML) are well known, but their correlation with long-term survivorship is unclear. …
IntroductionHumoral immunodeficiency is frequently observed in patients affected by chronic lymphocytic leukemia (CLL). The reasons for the compromised B-cell responses are only partly understood. We hypothesized that the normal residual B cells in CLL…
Antibody-drug conjugates (ADCs) offer selective delivery of potent cytotoxic payloads to tumour-associated antigens and are therefore attractive candidates for biomarker-informed treatment development. However, antigen heterogeneity, payload resistance…
ObjectiveBehçet’s disease (BD) may initially manifest solely with mucocutaneous involvement. This study aimed to identify demographic and clinical factors associated with subsequent intestinal involvement in patients presenting exclusively with mucocut…
BackgroundPancreatic ductal adenocarcinoma remains a malignancy with a dismal prognosis, characterized by a median overall survival of less than one year in the metastatic setting despite standard-of-care chemotherapy regimens like gemcitabine plus nab…
IntroductionPost-acute sequelae of SARS-CoV-2 (PASC) may develop after SARS-CoV-2 infection and cause a wide range of symptoms that can persist for years. Several pathophysiological mechanisms have been proposed, including dysregulation of the compleme…
