Immune involvement in psychosis is well supported, although most of the evidence comes from studies of negative and deficit symptoms. Grandiosity, in comparison, has received little attention. It is, however, the one symptom for which the two main acco…
IntroductionWe previously showed that human HMGB1 has anti-biofilm activity localized to a 97-amino-acid B-Box-derived peptide (mB Box-97), engineered with a C106S mutation to reduce HMGB1’s proinflammatory properties while retaining anti-biofilm funct…
Adoptive T-cell therapies using chimeric antigen receptors (CARs) or engineered T-cell receptors (TCRs) have transformed cancer treatment but remain limited by poor persistence and progressive T-cell exhaustion. Manufacturing strategies that promote me…
IntroductionAs an important cause of immune system dysfunction, stress can damage thymic stromal cells, leading to a persistent imbalance in thymic function. Thymic B cells can present autoantigens, playing a critical role in the establishment of centr…
ObjectiveTo describe the recorded prevalence and incidence of HS across pathologically related diseases within the spondyloarthritis (SpA) family, namely psoriatic arthritis (PsA), psoriasis, axial spondyloarthritis (axSpA), uveitis, Crohn’s disease, u…
BackgroundLung cancer remains the leading cause of cancer-related deaths in the United States, with over 124,000 estimated deaths for 2026. Previous studies have found that tumor-adjacent lung tissues may provide additional insight into the immune micr…
BackgroundChronic lymphocytic leukemia (CLL) is characterized by T-cell dysfunction that limits the efficacy of immunotherapies, including CD20×CD3 bispecific antibodies. Protein tyrosine phosphatases non-receptor type 2/1 PTPN2/PTPN1 are central intra…
Cancer immunotherapy with immune checkpoint inhibitors (ICIs), i.e., antibodies targeting inhibitory ICs, such as PD-1, PD-L1, and CTLA-4, have successfully revolutionized cancer treatment. One of the most promising cancer immunotherapies is based on b…
BackgroundInflammatory gastrointestinal disease is a common manifestation of inborn errors of immunity (IEI) and may affect any segment of the gastrointestinal tract. Vedolizumab, a gut-selective anti-integrin approved for inflammatory bowel disease, h…
BackgroundCD36 deficiency is a genetic disorder that can lead to fetal/neonatal alloimmune thrombocytopenia or platelet transfusion refractoriness. While CD36 deficiency caused by exonic mutations are well established, the RNA splicing mechanism by int…
