Hidradenitis suppurativa (HS) is a chronic, heterogeneous inflammatory skin disorder with limited therapeutic options. The immune checkpoint receptor TIGIT is emerging as a regulator of chronic inflammation, yet its role in HS remains unknown. Here, we…
BackgroundKawasaki disease (KD), a systemic vasculitis and the leading cause of acquired heart disease in children, stems from an uncontrolled inflammatory response that fails to resolve in up to 20% of IVIG-treated patients. This treatment resistance …
BackgroundPrimary Immunodeficiencies are inborn errors of immunity (IEIs) characterized by impaired immune function, resulting in recurrent infections, inflammation, autoimmunity, atopy, and malignancies. Although significant advances in diagnosis have…
BackgroundSerum biomarkers of multiple sclerosis (MS), such as glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL), are established indicators of disease progression and disability. Human endogenous retrovirus of the W family (…
Immune checkpoint receptors, including Sialic-acid-binding immunoglobulin-like lectins (Siglecs), are critical regulators of immune homeostasis. Siglecs can serve as negative regulators of Toll-like receptor (TLR) signaling, promoting the resolution of…
Immune checkpoint receptors, including Sialic-acid-binding immunoglobulin-like lectins (Siglecs), are critical regulators of immune homeostasis. Siglecs can serve as negative regulators of Toll-like receptor (TLR) signaling, promoting the resolution of…
Itaconate is produced by inflammatory macrophages and promotes negative feedback on inflammation. It is synthesized by aconitate decarboxylase 1 (ACOD1) from cis-aconitate, a metabolite of the tricarboxylic acid cycle. Here, we focused on the role of A…
IntroductionRecurrent febrile episodes account for one of the most frequent symptoms observed in Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome and a key target for therapeutic intervention. Therefore, this study aims at inve…
IntroductionMacrophages are highly plastic innate immune cells that have a broad range of phenotypic and functional roles in the body. The Wnt/β-catenin signaling pathway is known to play important roles in regulating the immune system, but the literat…
IntroductionMacrophages are highly plastic innate immune cells that have a broad range of phenotypic and functional roles in the body. The Wnt/β-catenin signaling pathway is known to play important roles in regulating the immune system, but the literat…
