All living organisms are enclosed by biological membranes composed primarily of phospholipids. The diversification of membrane lipids has shaped key membrane functions, including signaling, membrane protein regulation, and immune responses, and may als…
ObjectivesNeurological involvement is a heterogeneous complication of Sjögren’s disease (SjD). We aimed to describe its prevalence and spectrum, and identify factors associated with peripheral (PNS) and central nervous system (CNS) involvement.MethodsW…
Src family kinases (SFKs) share highly conserved catalytic domains yet display distinct biological functions, raising the question of how substrate specificity is achieved. Here, we investigate the basis of differential ITAM recognition by Lck and Src,…
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are immune-mediated peripheral neuropathies that may follow a progressive course and be refractory and poorly tolerated to standard immunomodulatory …
ObjectivesTo evaluate the therapeutic management of patients with active adult-onset Still’s disease (AOSD) in a multicentre real-world setting and to provide and compare current real-world treatment strategies with existing recent international recomm…
BackgroundAdjuvant treatment of melanoma patients with PD-1-based immunotherapy has improved recurrence rate, and became a standard treatment. However, a considerable proportion of patients recur within 1–2 years, necessitating the identification of pr…
Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory s…
ObjectivesOur aim was to investigate the association between diagnostic delay and the clinical and psychosocial features in patients with psoriatic arthritis (PsA), with particular focus on the mental health, wellbeing, and pain-related mechanisms.Meth…
IntroductionStem cell-derived organoids are promising platforms for therapeutic screening in inflammatory bowel disease (IBD), but identifying functional organoid readouts with translational utility is challenging. Colon epithelial organoids from patie…
Vaccination relies on innate and adaptive responses initiated at the injection site followed by activation in draining lymph nodes. However, high-plex, spatially resolved maps that couple injection site signals with transcriptomic programs in draining …
