Alternative splicing coupled to nonsense-mediated mRNA decay (AS-NMD) evolved as a master regulator of gene expression. Dysregulated AS-NMD has been identified as the root of many human maladies, from developmental defects to deadly cancer. Poison exon…
Chronic pharyngitis is a clinically heterogeneous condition in which persistent throat symptoms, visible mucosal abnormalities, and underlying biological processes do not necessarily coincide. This critical narrative review synthesizes evidence from hu…
BackgroundCoronary artery aneurysm is a major cardiovascular complication of Kawasaki disease (KD). The phenotype switch of vascular smooth muscle cells (VSMCs) plays a crucial role in pathological vascular wall remodeling in KD; however, the molecular…
Osteoarthritis (OA) is increasingly recognized as a whole-joint disease shaped by chronic low-grade inflammation, matrix damage, mechanical stress, and failed tissue repair. Beyond the traditional view of cartilage wear, emerging evidence indicates tha…
Immune-mediated outcomes diverge across individuals with similar genetic backgrounds and environmental exposures, reflecting trajectories through a dynamic, context-dependent, and partially stochastic state space rather than fixed molecular endpoints. …
Chronic kidney disease (CKD) exposes the circulation to sustained calcium-phosphate stress. Calciprotein particles (CPPs) buffer mineral supersaturation and, alongside mineral and bone disorder, uremic toxins, oxidative stress, and inflammation, are an…
IntroductionDespite effective antiretroviral therapy (ART), metabolic dysfunction persists in people with HIV (PWH) and may contribute to immune dysregulation and non-AIDS comorbidities. However, the metabolomic profiles associated with untreated infec…
Lysine crotonylation(Kcr), an important protein post-translational modification, establishes a connection between cellular metabolism and epigenetic regulation. This modification utilizes crotonyl-CoA as a donor and is co-regulated by “writers”, “erase…
BackgroundMethotrexate (MTX)-induced pulmonary fibrosis (MTX-PF) is the most severe and frequently irreversible manifestation of MTX pulmonary toxicity, yet the molecular target and signaling circuitry linking drug exposure to fibrosis remain undefined…
ObjectiveAnti-nuclear antibody (ANA) testing is widely used in the evaluation of systemic autoimmune rheumatic diseases (SARD). We evaluated ANA testing performed at Labcorp between 2015 and 2024 and examined serological associations between ANA titers…
