BackgroundSepsis is a life-threatening syndrome with dysregulated immune responses and multiple organ dysfunction. However, precise diagnostic biomarkers and effective therapeutic targets for this syndrome are still lacking. Protein ubiquitination modu…
BackgroundSevere mosquito bite allergy (SMBA) is characterized by intense local necrotic skin reactions accompanied by systemic symptoms following mosquito bites. SMBA is currently classified within the spectrum of EBV-positive T/natural killer (NK)-ce…
BackgroundCurrent therapeutic options for severe acute pancreatitis (SAP) remain limited. The integration of traditional Chinese and Western medicines offers a promising approach for patients with SAP, with Qingyi decoction (QYD) emerging as a classic …
BackgroundHepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with its incidence steadily rising over recent decades. Conventional treatments, including chemotherapy, surgery, immunotherapy, Targeted Therapy and radiot…
Despite advances in vessel recanalization, ischemic stroke remains a leading cause of mortality, highlighting the need for comprehensive neuroprotective strategies such as remote ischemic conditioning (RIC). This review evaluates the multitargeted mech…
Background and aimsSeasonal influenza virus infections represent a global health threat, especially in high-risk groups, including patients with liver cirrhosis that are considered to be immunocompromised, in particular in decompensated stages. Althoug…
Background and purposeInterferon-induced protein 27 (IFI27) is implicated in immune regulation, and regulatory T cells (Tregs) play a critical role in maintaining pulmonary immune homeostasis during sepsis. However, the relationship between IFI27 and T…
BackgroundProlonged indoor heat exposure disrupts immune homeostasis and can precipitate acute systemic inflammation. However, the core temperature threshold triggering sex-specific immune cell (leukocytes and neutrophils) mobilization during passive i…
BackgroundMany variants within the ABO gene across multiple subtypes have been identified. These variants are located in the coding region, the erythroid-specific regulatory element region of intron 1, splice sites, and other non-coding regions. Howeve…
Neutrophils are the most common type of white blood cell in the body, acting as crucial mediators of innate immunity. They initiate immune responses against invading microorganisms and threats like cancerous cells. Neutrophil infiltration is observed a…
