The dynamic interplay between vascular smooth muscle cells (VSMCs) and the immune microenvironment governs vascular repair and disease progression. This review systematically elucidates this multidimensional regulatory network. We primarily dissect the…
BackgroundCrohn’s disease (CD) shows marked histopathologic heterogeneity, and conventional histologic assessment remains dependent on subjective visual evaluation, limiting reproducibility and objective quantification. We aimed to develop and clinical…
ObjectiveTo investigate the unique dissemination phenotype of a mutant in OppA2 of Borrelia burgdorferi (Bb), one of the five encoded peptide binding proteins of the peptide transport system. Our previous study showed that loss of OppA2 abrogates hemat…
BackgroundThe therapeutic landscape of advanced hepatocellular carcinoma (HCC) has expanded beyond sorafenib, with multiple combination regimens now demonstrating improved outcomes. However, the absence of direct head-to-head comparisons complicates tr…
The presentation of mood disorders that involve agitation and anxiety in patients with cognitive loss represent significant challenges for the care of patients with Alzheimer’s disease (AD). Additional concerns rest with the rising lifespan and aging o…
Atopic diseases arise from an immunological imbalance where regulatory mechanisms are unable to preserve or restore homeostasis, leading to chronic inflammatory conditions affecting epithelial organs. This may involve homeostasis, deficient or insuffic…
N-acetyltransferase 10 (NAT10), the sole known mRNA N4-acetylcytidine (ac4C) writer, has emerged as a central regulator of cancer adaptation. Beyond its canonical role in RNA acetylation, NAT10 integrates environmental stress signals—including hypoxia,…
BackgroundAndes orthohantavirus (ANDV) is a deadly pathogen that causes hantavirus cardiopulmonary syndrome (HCPS), which is a severe disease characterized by respiratory failure and high mortality rates (~30–40%). While previous studies have shown tha…
BackgroundGermline monoallelic gain-of-function (GOF) variants in NFKBIA, encoding IκBα, cause a rare immunodeficiency syndrome classically described as autosomal-dominant anhidrotic ectodermal dysplasia with immunodeficiency. However, the pathogenic s…
Colorectal cancer (CRC) remains a major cause of cancer-related death, yet the benefits of immune checkpoint inhibitors are limited to a small subset of patients, particularly those with microsatellite instability-high or mismatch repair-deficient tumo…
