BackgroundChronic inflammatory rheumatic diseases, such as ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis, are collectively referred to as spondyloarthropathies (SpA). However, Real-world evidence on the eff…
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease of the esophagus in which symptoms, histologic activity, endoscopic severity, epithelial dysfunction, and fibrostenotic remodeling frequently diverge. Peak eosinophil density remains …
Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease with limited evidence guiding its management. We report a 49-year-old woman with refractory anti-p200 pemphigoid who failed treatment with high-dose prednisone and dapsone and de…
Modern disease-modifying therapy has transformed rheumatoid arthritis. Even so, many patients cycle through biological and targeted synthetic drugs of distinct mechanisms without achieving sustained remission. This is the difficult-to-treat phenotype d…
BackgroundPathological response after neoadjuvant chemotherapy is a key treatment milestone in osteosarcoma. We evaluated whether a rule-derived preoperative peripheral inflammatory-lymphocyte recovery phenotype constructed from routinely collected lab…
Bullous Pemphigoid (BP) is the most common autoimmune blistering disorder, predominantly affecting elderly patients and often requiring prolonged immunosuppression. Conventional therapies are frequently limited by adverse effects and incomplete disease…
Kawasaki disease (KD) is an acute systemic vasculitis that can affect multiple organs. Kawasaki disease shock syndrome (KDSS) is a severe complication of KD. Pulmonary involvement is uncommon in KD, and there are very few reports of patients with KD wh…
Mitophagy serves as a pivotal metabolic-immune hub that drives immune evasion in major skin cancer subtypes including melanoma cutaneous squamous cell carcinoma and basal cell carcinoma. It acts as a core barrier to effective immunotherapy. Mitophagy a…
IntroductionOnly a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined.MethodsWe established a barcoded KrasG12D, Trp53 loss mouse LUAD organoid m…
Hepatocellular carcinoma (HCC) commonly develops in the context of chronic liver injury and fibrosis, and its immune evasion and therapeutic resistance are shaped not only by tumor-intrinsic factors but also by persistent interactions between the tumor…
