Neonatal respiratory infections remain a leading cause of mortality and morbidity worldwide, yet there is still little information about the role of B cell populations in the respiratory tract. CD19+B220lo are B cells that are found in neonatal lungs, …
BackgroundPoly (ADP-ribose) polymerase inhibitors (PARPi) have improved outcomes in ovarian cancer with homologous recombination deficiency (HRD). However, approximately half of high-grade serous ovarian cancers retain intact homologous recombination r…
BackgroundTraumatic lung injury (TLI) frequently progresses to acute respiratory distress syndrome (ARDS), a condition with high mortality and limited targeted therapies. This study aimed to identify specific immune cell drivers and potential therapeut…
BackgroundIn the era of letermovir for cytomegalovirus (CMV) prophylaxis, several centers reported that the incidence of Epstein-Barr virus (EBV) infection were significantly increased.ObjectiveTo investigate the efficacy and safety of rituximab admini…
Protein lactylation, a novel post-translational modification (lysine lactylation, Kla) driven by the oncometabolite lactate, has emerged as a critical epigenetic mechanism that directly links cellular metabolic state to gene regulation. Within the tumo…
BackgroundNeoadjuvant chemoimmunotherapy improves pathological response in resectable non-small cell lung cancer (NSCLC), but response remains heterogeneous. PD-L1 tumor proportion score (TPS) incompletely captures spatial immune contexture. We develop…
Primary membranous nephropathy (PMN) is a single-organ autoimmune disease caused by autoantibodies targeting podocyte-associated antigens, most commonly phospholipase A2-receptor (PLA2R). Although 14 other antigens have been identified, the target rema…
The nervous system is increasingly recognized as an active regulator of oncogenesis rather than a passive structural component of the tumor microenvironment (TME). Neural activity promotes tumor proliferation, invasion, metastasis, therapeutic resistan…
PurposeRadiation-induced lymphopenia (RIL) has been well known to associate with poor patient prognosis. Based on interesting findings in our previous study, we hypothesize that a low dose of 5-Gy can damage erythrocytes, which indirectly depletes lymp…
Chronic inflammatory diseases of the spine, typified by axial spondyloarthritis (axSpA) and intervertebral disc degeneration (IDD), impose a substantial burden through refractory pain and irreversible structural remodelling (pathological ossification o…
