IntroductionDose-adjusted tacrolimus exposure phenotype, expressed as the trough concentration-to-dose ratio (C0/Dose), may influence post-transplant outcomes, but supporting evidence remains limited.MethodsWe evaluated the association between tacrolim…
Chimeric antigen receptor (CAR) T cells represent an exciting therapeutic strategy with improved survival outcomes for patients with hematological malignancies. However, the efficacy of CAR T-cell therapy in the treatment of solid tumors remains subopt…
Homologous to the E6-AP Carboxyl Terminus (HECT)-type E3 ubiquitin ligases are key components of the ubiquitin-proteasome system (UPS) and play an important role in the regulation of inflammatory responses. Inflammation serves as a core defense mechani…
IntroductionAcute Lymphoblastic Leukemia (ALL) remains the most prevalent childhood malignancy. While chemotherapy has improved survival rates, multidrug resistance (MDR) mediated by P-glycoprotein (P-gp/ABCB1) overexpression persists as a major cause …
Nerve Injury-Induced Protein 1 (Ninjurin-1) is an adhesion molecule implicated in inflammation and tissue injury, yet its role in neuroinflammatory diseases such as multiple sclerosis (MS) remains poorly defined. Here, we identify Ninjurin-1 as a marke…
ObjectivePemphigoid is a rare autoimmune disorder that may be drug-induced. This study aims to investigate the potential association between pemphigoid and quinolone using the FDA Adverse Event Reporting System (FAERS) database.MethodsFAERS reports wer…
Gut microbiota plays a pivotal role in host immunity and overall health. Enterococcus faecium HDRsEf1 (Ef1), a novel potential probiotic, has been reported to enhance immune defense against pathogenic invasion; however, its effects on inflammation and …
BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients have a significantly increased risk of developing osteoporosis (OP) and osteopenia. Despite numerous studies, the global burden of SLE-related OP, its region…
The chemokine CXCL12 and its receptor CXCR4 play context-dependent roles in hair follicle biology. While recent findings suggest that regulatory T cells (Tregs) utilize the CXCL12–CXCR4 axis to modestly promote hair follicle regeneration under homeosta…
Caspase-1 is known to function intracellularly. However, whether caspase-1 can be released extracellularly and if so, the mechanisms of its release and action remain unknown. Here, we identify that cleaved caspase-1 (p20), which we named extracellular …
