Genome-wide association studies have linked CARS2 locus, encoding the mitochondrial cysteinyl aminoacyl-tRNA synthetase CARS2, to coronary artery disease. Moreover, we previously demonstrated that CARS2 suppression was associated with a pro-inflammator…
Colorectal Cancer (CRC) accounts for the second highest number of cancer-related mortalities rate worldwide, and its incidence and mortality is expected to continue to increase in the coming years. Over 80% of CRC cases are caused by mutation in the Ad…
Vascular fibrosis is a major contributor to hypertension and cardiovascular disease and is caused by excessive extracellular matrix deposition and tissue stiffening. Macrophages and fibroblasts are key regulators of this process, yet most studies have …
BackgroundIschemic stroke thrombi contain complex immunothrombotic components, including neutrophil extracellular traps (NETs), which contribute to thrombus stability and resistance to fibrinolysis. However, the endogenous triggers of NETosis within st…
BackgroundImmune cells must adapt to highly variable oxygen levels encountered across different tissues of the body. Under inflammatory conditions, oxygen levels may reach further extremes, for example healthy synovial joints display oxygen levels of 6…
Myo-inositol (MI) plays an important role in intracellular signaling, cell proliferation, and cell growth, and has been associated with positive effects on the immune system and health in fish. However, its potential immunological effects in poultry ha…
Background/aimThe prognostic immune and nutritional index (PINI) has been increasingly recognized as a significant parameter associated with clinical outcomes in multiple cancers. Nevertheless, its prognostic role in esophageal squamous cell carcinoma …
Risk factors for relapse and non-relapse mortality (NRM) in the first years after allogeneic hematopoietic stem cells transplant (allo-HSCT) for acute myeloid leukemia (AML) are well known, but their correlation with long-term survivorship is unclear. …
IntroductionHumoral immunodeficiency is frequently observed in patients affected by chronic lymphocytic leukemia (CLL). The reasons for the compromised B-cell responses are only partly understood. We hypothesized that the normal residual B cells in CLL…
Antibody-drug conjugates (ADCs) offer selective delivery of potent cytotoxic payloads to tumour-associated antigens and are therefore attractive candidates for biomarker-informed treatment development. However, antigen heterogeneity, payload resistance…
