A paper, “Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit,” published in Protein & Cell uncovers a previously unappreciated mechanism by which macrophages influence the fate of C…
In a recent online publication in Science China Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled “Molecular Me…
Research from Radboud university medical center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory of innate immune cells operated independently.
The growth of healthy tissues in the body depends on the development of new blood vessels, a process called angiogenesis, that enables proper blood flow, meaning nutrients and oxygen are delivered while toxic metabolic products are removed.
Immunotherapy has revolutionized cancer treatment, with immune checkpoint inhibitors (ICIs) playing a pivotal role. However, current ICIs, primarily monoclonal antibodies, face significant challenges like poor tissue penetration, high production costs,…
A new editorial titled “Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity” has been published in Oncotarget.
The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, researchers from Japan report a new protein–protein interaction that coul…
Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin. Lupus myocarditis—inflammation …
Hepatitis C virus (HCV)-related diseases such as chronic hepatitis C, liver cirrhosis, and liver cancers afflict a large number of people worldwide. A recent study from Korea University suggests that treatment with direct-acting antivirals (DAAs) impro…
To evade the human host’s immune response, SARS-CoV-2, the coronavirus that causes COVID-19 uses the machinery of defense cells to induce the expression of unproductive isoforms of key antiviral genes—variant forms of genes that result from disrupted s…
