Injectable drug helps asthma patients clear mucus-clogged airways
An anti-inflammation injectable drug can reduce mucus buildup and improve breathing among asthma patients, a new clinical trial says.
Medical Xpress
Perineural pathway that fuels HIV persistence despite treatment identified
Addressing the question of whether and how immune cells (macrophages) in the central nervous system (CNS) traffic out, researchers have now identified a perineural pathway through which the HIV virus can redistribute throughout the body. The findings f…
In-surgery radiation cuts pancreatic cancer return
Using targeted radiation during surgery—referred to as intraoperative radiation—to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce the recurrence rate around the p…
Clinical trial presents promising DNA-encoded therapy for long-lasting protection against COVID-19
A new way to deliver protective antibodies against COVID-19 was tested in a Phase I clinical trial. Instead of injecting pre-made antibodies into patients, this approach encouraged the body to produce its own antibodies to fight off the disease-causing…
Making cancer vaccines more personal
In a new study, University of Arizona researchers created a model for cutaneous squamous cell carcinoma, a type of skin cancer, and identified two mutated tumor proteins, or neoantigens, that contain features of good candidates for a vaccine.
Oxygen deprivation heightens risk of illness by changing genes, researchers discover
Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body’s ability to fight infection, new research shows.
Custom-designed protein receptors help T cells target solid tumors more effectively
Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer treatment. But while they’…
Bisphenol A causes sex-specific changes in metabolism and the immune system, study reveals
Even small amounts of bisphenol A can lead to long-term health effects. When researchers studied adult rats exposed in the fetal stage, they found that females had developed a more masculine and males a more feminine gene expression pattern. This led t…
Promising new drug combination for melanoma patients resistant to treatment
Melanoma is the most common form of skin cancer, but for patients with advanced melanoma who no longer respond to standard immunotherapy, treatment options are painfully limited. Vanderbilt researchers led by Professor Emerita of Pharmacology Ann Richm…
Immune cells linked to allergies may double as defenders against Candida infections
A new study has uncovered how a surprising player in the immune system, eosinophils, best known for their role in allergies and asthma, also helps protect the body against Candida albicans, one of the most common and dangerous fungal infections in humans.