Cancer cells ‘hacked’ to expose themselves to immune attack
When your social media account starts spewing out nonsensical or threatening status updates, it’s safe to assume that it has been hacked and must be shut down.
Inmunología
Common anticancer drugs may offer new hope to PTEN Hamartoma Tumor Syndrome patients
During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these actions to avoid non-programmed growth that could le…
Stem cell infusion timing can prevent acute graft-versus-host disease
A research team has identified the impact of stem cell infusion timing on the incidence and severity of acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), highlighting the role of the recipient’s …
A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every once in a while, we stumble upon something unexpected—something that completely changes the way we see an infection.
Researchers identify mutations that can lead to resistance to some chemotherapies
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35…
How a critical enzyme keeps potentially dangerous genes in check
The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress TE activity and keep themselves healthy.
How melanoma and other tumors succeed in hiding and resisting immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas often escape immune system …
Nasal protein could aid in early COPD detection
Early diagnosis of COPD, chronic obstructive pulmonary disease, increases the quality of life of the patient and the efficacy of available treatments. Researchers at Karolinska Institutet have now shown that material from nasal lavage provides a basis …
Clinical trials show new antibody therapy offers long-lasting HIV control without daily medication
If the past four decades have taught us anything about HIV, it’s to adjust our expectations—despite enormous progress in controlling the virus, no treatment can yet completely eradicate HIV once it has taken hold. But promising results from a recent cl…
Scientists uncover how TBK1 and IKKε prevent premature cell death and inflammation
New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are particularly relevant for peopl…