Sarepta’s gene therapy under scrutiny after patient death
A patient has died while receiving Elevidys, a gene therapy for Duchenne muscular dystrophy, marking the first known death linked to the treatment.
Noticias
Built-in safeguard in B cell populations could impact vaccine design
Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check. But rapid evo…
New understanding of B cell mutation strategies could have implications for vaccines
A vaccine’s ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodie…
Scientists discover a type of immune cell that produces defensive ‘shields’ in the skin
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Dr. Andrés Hidalgo has discovered a specialized population of neutrophils in the skin that produce extracellular matrix, helping to maintain the skin’s resistance and integ…
Illuminating the immune response to aberrant DNA
Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as well as transformation during cancer. Researchers led by Ikerbasque Research Professor Sergio P. Acebrón (University of the Basque…
‘Aging clock’ computer model reveals aging processes in immune cells
Not only does our body change with age, but so does our immune system. A recent study led by the Center for Individualized Infection Medicine (CiiM) shows exactly how immune cells age and how infections and vaccinations can influence this process. The …
Vaccine may improve breast cancer treatment outcomes
Researchers have discovered a promising new vaccine strategy for treating a specific type of breast cancer. The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positive, ER-negative) breas…
Researchers find missing link in autoimmune disorder
Scientists have identified a protein in cells that spurs the release of infection-fighting molecules. The protein, whose role in the immune system had not previously been suspected, provides a potential target for therapies that could prevent over-reac…
Dendritic cell vaccine strategy may improve breast cancer treatment outcomes
Moffitt Cancer Center researchers have discovered a promising new vaccine strategy for treating a specific type of breast cancer. The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positi…
Researchers uncover key mechanisms driving oral cancer spread and highlight potential treatment strategies
A collaborative research team from The University of Hong Kong (HKU) and West China Hospital of Sichuan University has made a breakthrough in understanding the spread of oral squamous cell carcinoma (OSCC), a prevalent and aggressive form of mouth cancer.