Current Opinion in Immunology

Curr Opin Immunol. 2026 Jul 15;102:102817. doi: 10.1016/j.coi.2026.102817. Online ahead of print. ABSTRACT Germline mutations in GATA2 cause a syndromic inborn error of immunity characterized by cytopenia, infections, immune dysregulation, and a marked predisposition to myelodysplastic syndrome and acute myeloid leukemia. Initially defined by the DCML phenotype-dendritic cell, monocyte, B- and NK-cell deficiency-GATA2 deficiency is … Read more

Curr Opin Immunol. 2026 Jul 10;102:102816. doi: 10.1016/j.coi.2026.102816. Online ahead of print. ABSTRACT Antibodies are fundamental to human health but can also drive pathology. Each antibody has a molecular specificity, encoded by their clonally heritable B cell receptor (BCR). Recent advances in spatial transcriptomics coupled with repertoire sequencing have enabled capturing antibody-secreting cells (ASCs) and … Read more

Curr Opin Immunol. 2026 Jul 9;102:102815. doi: 10.1016/j.coi.2026.102815. Online ahead of print. ABSTRACT Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by sicca symptoms, fatigue, multiorgan involvement, and an increased risk of B-cell lymphoma. Accumulating evidence over the past decades indicates that epithelial cells are not passive targets but active drivers of disease. … Read more

Curr Opin Immunol. 2026 Jul 7;101:102812. doi: 10.1016/j.coi.2026.102812. Online ahead of print. ABSTRACT Microbial transglutaminase (mTG) is a frequently used processed food additive, and the consumption of its cross-linked complexes is rapidly expanding. Despite numerous reports concerning its public safety, it is designated as a processing aid and classified as safe for use. mTG and/or … Read more

Curr Opin Immunol. 2026 Jul 7;101:102811. doi: 10.1016/j.coi.2026.102811. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is not a uniform inflammatory pannus. It is a spatially organized, stage-dependent synovial immune ecosystem. Cellular cartography resolves synovitis into lymphoid, myeloid, stromal, and neuroimmune niches that track erosive disease, fibroproliferation, and pain-dominant states. Ecosystem state can differ between … Read more

Curr Opin Immunol. 2026 Jul 6;101:102813. doi: 10.1016/j.coi.2026.102813. Online ahead of print. ABSTRACT Ion channels are classically regarded as regulators of electrical excitability, but their role in immune activation and barrier homeostasis extends far beyond global transmembrane ion flux. This functional diversity is, among other things, the result of noncanonical signaling pathways. In this review, … Read more

Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, … Read more

Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key … Read more

Curr Opin Immunol. 2026 Jun 27;101:102810. doi: 10.1016/j.coi.2026.102810. Online ahead of print. ABSTRACT Ocular sarcoidosis is a frequent manifestation of sarcoidosis and may occur most commonly affecting adults between 30 and 60 years old. Uveitis may be anterior, intermediate, posterior, or present as panuveitis, with marked heterogeneity in severity and clinical course. Diagnosis relies on … Read more

Curr Opin Immunol. 2026 Jun 26;101:102808. doi: 10.1016/j.coi.2026.102808. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has renewed interest in mucosal vaccines, yet these approaches have long struggled to generate durable protection against airway pathogens. A key limitation is the incomplete understanding of how upper airway antigens are handled to shape immune response quality and … Read more