Current Opinion in Immunology

Curr Opin Immunol. 2026 Jun 4;101:102804. doi: 10.1016/j.coi.2026.102804. Online ahead of print. ABSTRACT Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by inhaling aerosolized rodent excreta, the Andes virus variant is capable of human-to-human … Read more

Curr Opin Immunol. 2026 Jun 2;101:102790. doi: 10.1016/j.coi.2026.102790. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is composed of diverse heterogeneous components and plays a crucial role in immune cell infiltration, immune evasion, and dynamic interactions between tumor cells and the immune system. A precise understanding of the TME is essential for tissue immunology … Read more

Curr Opin Immunol. 2026 May 29;101:102791. doi: 10.1016/j.coi.2026.102791. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is a thromboinflammatory disorder in which antiphospholipid antibodies (aPL), particularly anti-β2GPI, initiate a complex, graded platelet activation that integrates immune signaling with coagulation. Clinical and multiparametric flow-cytometric evidence demonstrates a sustained prothrombotic platelet endotype characterized by enrichment of tissue … Read more

Curr Opin Immunol. 2026 May 27;101:102792. doi: 10.1016/j.coi.2026.102792. Online ahead of print. ABSTRACT Sarcoidosis is a heterogeneous granulomatous disease of unknown origin; a subset of patients develops an advanced pulmonary disease phenotype, marked by progressive pulmonary fibrosis, airway involvement, and sarcoidosis-associated pulmonary hypertension, leading to high morbidity and mortality. In this review, we summarize key … Read more

Curr Opin Immunol. 2026 May 23;101:102789. doi: 10.1016/j.coi.2026.102789. Online ahead of print. ABSTRACT Traumatic knee injuries in skeletally immature patients occur in a unique biological context shaped by growth, high tissue turnover, and distinct immune-repair dynamics. Beyond structural damage, acute post-traumatic changes in synovial fluid and cartilage metabolism can set the trajectory toward persistent symptoms … Read more

Curr Opin Immunol. 2026 May 21;101:102785. doi: 10.1016/j.coi.2026.102785. Online ahead of print. ABSTRACT Despite the success of targeted therapies in rheumatoid arthritis, the lack of predictive biomarkers of response leads to an empirical treatment approach, often delaying effective intervention due to non-response to the initially selected individualized medication regimens in approximately 40% of patients. Cellular … Read more

Curr Opin Immunol. 2026 May 15;101:102788. doi: 10.1016/j.coi.2026.102788. Online ahead of print. ABSTRACT The spleen is a central immune organ that surveys blood-borne pathogens and coordinates systemic immune responses. Within this organ, conventional dendritic cell (cDC) subsets occupy blood-exposed niches that enable efficient antigen capture and rapid initiation of T cell activation. While splenic cDC1s … Read more

Curr Opin Immunol. 2026 May 14;100:102786. doi: 10.1016/j.coi.2026.102786. Online ahead of print. ABSTRACT Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis, fibrosis, and eventual cirrhosis. Despite advances in understanding disease pathogenesis, treatment pathways are focused on maintenance rather than cure. Moreover, … Read more

Curr Opin Immunol. 2026 May 13;100:102787. doi: 10.1016/j.coi.2026.102787. Online ahead of print. ABSTRACT Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-presenting cells (APCs) in space and time. This spatiotemporal problem of immunity is solved by secondary lymphoid organs, such as lymph nodes (LNs), which coordinate adaptive … Read more

Curr Opin Immunol. 2026 May 4;100:102784. doi: 10.1016/j.coi.2026.102784. Online ahead of print. ABSTRACT The lupus anticoagulant (LA) phenomenon represents a paradoxical prothrombotic state characterised by inhibition of phospholipid-dependent coagulation assays in vitro, despite a strong association with thrombosis and pregnancy morbidity in vivo. LA is a central laboratory criterion for the diagnosis and risk stratification … Read more