Current Opinion in Immunology

Curr Opin Immunol. 2026 Mar 14;100:102757. doi: 10.1016/j.coi.2026.102757. Online ahead of print. ABSTRACT Kv1.3 is a voltage-gated potassium channel expressed on immune cells. It functions in coordination with calcium channels to maintain cellular homeostasis. Several studies support important roles for Kv1.3 in microglia-driven neuroinflammation and T cell-mediated autoimmunity. Based on recent evidence, Kv1.3 may regulate … Read more

Curr Opin Immunol. 2026 Mar 13;100:102756. doi: 10.1016/j.coi.2026.102756. Online ahead of print. ABSTRACT We are at the dawn of a new era in the biomedical prevention of childhood malaria. The successful development and ongoing rollout of the first malaria vaccines, RTS,S/AS01E and R21/Matrix-M, have injected much-needed optimism into the malaria prevention field. Additional new vaccines … Read more

Curr Opin Immunol. 2026 Mar 12;100:102752. doi: 10.1016/j.coi.2026.102752. Online ahead of print. ABSTRACT P2 purinergic receptors are activated by extracellular adenosine triphosphate and other nucleotides released during inflammatory processes, cellular stress responses, and amplification by NETosis, thereby serving as pivotal mediators of both innate and adaptive immunity. In patients with active systemic lupus erythematosus (SLE), … Read more

Curr Opin Immunol. 2026 Mar 10;100:102749. doi: 10.1016/j.coi.2026.102749. Online ahead of print. ABSTRACT Graft versus host disease (GVHD) is one of the major complications of allogeneic hematopoietic cell transplantation (allo-HCT), contributing significantly to post-transplant morbidity and mortality. Anti-thymocyte globulin (ATG) is a widely used GVHD prophylaxis in combination with a calcineurin inhibitor and an antimetabolite. … Read more

Curr Opin Immunol. 2026 Mar 10;100:102753. doi: 10.1016/j.coi.2026.102753. Online ahead of print. ABSTRACT The complexity and heterogeneity of autoimmune diseases are only partially captured by current analytic tools, even when deep learning techniques are employed to intercept patterns beyond existing dogma. Synthetic data offer a newer paradigm through machine-generated reconstructions of real-world data that faithfully … Read more

Curr Opin Immunol. 2026 Mar 10;100:102748. doi: 10.1016/j.coi.2026.102748. Online ahead of print. ABSTRACT The term autoimmune disease refers to autoantibody-dependent pathophysiological conditions, in which characterising the autoantibodies is essential, as is studying their target(s), the (auto)antigen(s), which represent the other side of the coin. In this review, we aimed to go further inside the ultimate … Read more

Curr Opin Immunol. 2026 Mar 3;100:102750. doi: 10.1016/j.coi.2026.102750. Online ahead of print. ABSTRACT The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, KV1.3 has been postulated to exert additional functions … Read more

Curr Opin Immunol. 2026 Mar 3;100:102751. doi: 10.1016/j.coi.2026.102751. Online ahead of print. ABSTRACT Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates neuroinflammation and contributes to a range of central nervous system pathologies. Our recent work … Read more

Curr Opin Immunol. 2026 Mar 3;100:102743. doi: 10.1016/j.coi.2026.102743. Online ahead of print. ABSTRACT Despite major advances in understanding Sjögren’s disease (SjD), no approved disease-modifying therapies have been approved. Management remains largely symptomatic with the use of off-label immunomodulators for systemic features. This gap highlights the substantial unmet need for targeted treatment. Encouragingly, the therapeutic landscape … Read more

Curr Opin Immunol. 2026 Mar 3;100:102747. doi: 10.1016/j.coi.2026.102747. Online ahead of print. ABSTRACT Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this … Read more