Current Opinion in Immunology

Curr Opin Immunol. 2024 Dec 16;92:102523. doi: 10.1016/j.coi.2024.102523. Online ahead of print. NO ABSTRACT PMID:39689416 | DOI:10.1016/j.coi.2024.102523

Curr Opin Immunol. 2024 Dec 14;92:102512. doi: 10.1016/j.coi.2024.102512. Online ahead of print. ABSTRACT Noncanonical inflammasomes are instrumental in defense against Gram-negative bacteria, activated primarily by bacterial lipopolysaccharide. This review examines commonalities and distinctions in noncanonical inflammasome activation either by virulence factor activity indicating cellular invasion or by detection of bacterial mRNA signaling the undesired presence … Read more

Curr Opin Immunol. 2024 Dec 14;92:102513. doi: 10.1016/j.coi.2024.102513. Online ahead of print. ABSTRACT This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France. PMID:39675153 | … Read more

Curr Opin Immunol. 2024 Dec 12;92:102511. doi: 10.1016/j.coi.2024.102511. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive … Read more

Curr Opin Immunol. 2024 Dec 10;92:102510. doi: 10.1016/j.coi.2024.102510. Online ahead of print. ABSTRACT Local regulation of T cell-mediated immunity to solid tumors occurs at multiple levels, including their recruitment from the bloodstream to the tumor microenvironment (TME), coordinated crosstalk with different subsets of antigen-presenting cells (APCs) controlling their local survival, proliferation, and effector differentiation, as … Read more

Curr Opin Immunol. 2024 Dec 5;92:102509. doi: 10.1016/j.coi.2024.102509. Online ahead of print. ABSTRACT Allergies result from an antigen-specific loss of tolerance against innocuous foreign substances. Allergen immunotherapy (AIT) aims to reverse the pathogenic response and to re-establish physiological tolerance. However, the tolerogenic mechanisms that prevent allergy in healthy and act during AIT are still obscure. … Read more

Curr Opin Immunol. 2024 Dec 4;92:102508. doi: 10.1016/j.coi.2024.102508. Online ahead of print. ABSTRACT Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for the view that tuberculosis is an interferonopathy – a disease driven by type I interferons. However, how type I interferons exacerbate … Read more

Curr Opin Immunol. 2024 Nov 25;92:102506. doi: 10.1016/j.coi.2024.102506. Online ahead of print. ABSTRACT Accumulating evidence demonstrates that tumor-specific CD8+ T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8+ T (TPEX) cells and newly defined tumor-specific memory subsets … Read more

Curr Opin Immunol. 2024 Nov 22;91:102507. doi: 10.1016/j.coi.2024.102507. Online ahead of print. ABSTRACT The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions … Read more

Curr Opin Immunol. 2024 Nov 19;91:102505. doi: 10.1016/j.coi.2024.102505. Online ahead of print. ABSTRACT Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and … Read more