Current Opinion in Immunology

Curr Opin Immunol. 2026 Sep 10;103:102834. doi: 10.1016/j.coi.2026.102834. Online ahead of print. ABSTRACT BACKGROUND: Macrophage activation syndrome (MAS) is a rare but potentially life-threatening complication of juvenile dermatomyositis (JDM). Data on its clinical presentation, diagnosis, treatment, and outcomes remain limited. OBJECTIVE: To systematically review the literature on MAS occurring in patients with JDM. METHODS: A … Read more

Curr Opin Immunol. 2026 Sep 10;103:102839. doi: 10.1016/j.coi.2026.102839. Online ahead of print. ABSTRACT Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in childhood is a rare but severe condition associated with significant morbidity and treatment-related toxicity. Current therapies mainly rely on high-dose glucocorticoids and conventional immunosuppressants, which may cause substantial long-term adverse effects in pediatric patients. Advances … Read more

Curr Opin Immunol. 2026 Sep 8;103:102837. doi: 10.1016/j.coi.2026.102837. Online ahead of print. NO ABSTRACT PMID:42715888 | DOI:10.1016/j.coi.2026.102837

Curr Opin Immunol. 2026 Aug 27;102:102836. doi: 10.1016/j.coi.2026.102836. Online ahead of print. ABSTRACT Intestinal immunity is coordinated by the spatial organization and temporal regulation of immune cells within a complex, antigen-rich environment. In this review, we discuss the latest advances in our understanding of how these two fundamental dimensions together shape intestinal immune homeostasis. We … Read more

Curr Opin Immunol. 2026 Aug 14;102:102835. doi: 10.1016/j.coi.2026.102835. Online ahead of print. ABSTRACT Multimodal artificial intelligence (AI) is an emerging domain comprising a set of tools with potential clinical relevance in paediatric rheumatology, a field characterised by rare, heterogeneous diseases and diagnostic delays. This narrative review synthesises current evidence on how multimodal and fair AI … Read more

Curr Opin Immunol. 2026 Aug 3;102:102832. doi: 10.1016/j.coi.2026.102832. Online ahead of print. ABSTRACT Real-world data (RWD) from nonrandomized clinical settings, such as registries and observational cohorts, can be used to address research questions for which randomized controlled trials (RCTs) are not feasible or appropriate. However, these data are susceptible to important sources of bias, including … Read more

Curr Opin Immunol. 2026 Jul 31;102:102833. doi: 10.1016/j.coi.2026.102833. Online ahead of print. ABSTRACT Recurrent pericarditis complicates approximately one-third of initial pericarditis episodes in children. Once considered a postinfectious sequel, it is now understood as an autoinflammatory disorder sustained by dysregulated interleukin-1 signaling and inflammasome hyperactivation. This review evaluates therapeutic strategies for idiopathic recurrent pericarditis in … Read more

Curr Opin Immunol. 2026 Jul 30;102:102814. doi: 10.1016/j.coi.2026.102814. Online ahead of print. ABSTRACT Spatial transcriptomic and proteomic atlases have enabled mapping of gene programs within intact tissues, but these measurements remain largely descriptive and do not define the mechanisms controlling tissue biology. Pooled CRISPR screening provides scalable causal interrogation of gene function but remains largely … Read more

Curr Opin Immunol. 2026 Jul 29;102:102829. doi: 10.1016/j.coi.2026.102829. Online ahead of print. ABSTRACT Tumors are spatially heterogeneous ecosystems in which malignant, stromal, vascular, and immune cells interact within metabolically distinct niches. These localized microenvironments are shaped by factors such as nutrient availability, hypoxia, acidosis, and immunomodulatory metabolites, all of which strongly influence CD8⁺ T cell … Read more

Curr Opin Immunol. 2026 Jul 28;102:102830. doi: 10.1016/j.coi.2026.102830. Online ahead of print. ABSTRACT Over the last two years, inflammatory dermatology has undergone a transition from morphology-based classification toward pathway-driven immune endotyping. Atopic dermatitis, psoriatic disease, and hidradenitis suppurativa have emerged as paradigmatic models of this transition, illustrating how epithelial dysfunction, involving autoinflammation and adaptive immunity, … Read more