Curr Opin Immunol. 2026 Feb 11;99:102735. doi: 10.1016/j.coi.2026.102735. Online ahead of print. ABSTRACT The clinical heterogeneity of rheumatoid arthritis (RA) reflects a series of dynamic immunological imbalances rather than a single dominant mechanism. In this review, we propose that RA progression is best understood as a sequence of three functional balances. The first contrasts pathogenic … Read more

Curr Opin Immunol. 2026 Jan 27;99:102726. doi: 10.1016/j.coi.2026.102726. Online ahead of print. ABSTRACT Malaria during pregnancy continues to compromise maternal, fetal, and subsequently infant health. This burden has increased in Africa, though it has decreased elsewhere. Here, we provide a concise review of recent findings on malaria in pregnancy, addressing pathogenesis, immunity, offspring outcomes, and … Read more

Curr Opin Immunol. 2026 Jan 23;99:102723. doi: 10.1016/j.coi.2025.102723. Online ahead of print. ABSTRACT The incidence, prevalence, and burden of sarcoidosis is increasing worldwide. The Nordic countries have the highest incidence with lowest rates reported in Asia. In the United States, Black females have the highest incidence and prevalence of disease. The phenotypic manifestations of sarcoidosis … Read more

Curr Opin Immunol. 2026 Jan 22;99:102724. doi: 10.1016/j.coi.2026.102724. Online ahead of print. ABSTRACT As of 2024, the World Health Organization declared the Zika virus (ZIKV), an emerging flavivirus, as a high-priority pathogen with the potential to cause future Public Health Emergencies of International Concern. Although the last major outbreak of ZIKV occurred in 2015-2016, ongoing … Read more

Curr Opin Immunol. 2026 Jan 22;99:102725. doi: 10.1016/j.coi.2026.102725. Online ahead of print. ABSTRACT We report on 13 classic infantile Pompe patients, including four cross-reactive immunological material negative (31%), treated with alglucosidase alpha (rhGAA) at Fondazione IRCCS San Gerardo, Monza, between 2003 and 2024. Median age at rhGAA initiation was 3.3 months, with nine patients (69%) … Read more

Curr Opin Immunol. 2026 Jan 14;99:102720. doi: 10.1016/j.coi.2025.102720. Online ahead of print. ABSTRACT Patients with sarcoidosis can present with a wide range of symptoms that impact their quality of life (QoL). QoL represents one of the most important treatment priorities for patients. Therefore, measuring what matters to patients is of great importance, though it can … Read more

Curr Opin Immunol. 2026 Jan 13;99:102721. doi: 10.1016/j.coi.2025.102721. Online ahead of print. ABSTRACT Elderly-onset rheumatoid arthritis (EORA), defined as onset at ≥60 years, is a clinically distinct and increasingly prevalent subset of rheumatoid arthritis (RA). This review synthesizes evidence that EORA is not merely late-onset RA but a pathogenically unique entity, driven by immune aging, … Read more

Curr Opin Immunol. 2026 Jan 13;99:102719. doi: 10.1016/j.coi.2025.102719. Online ahead of print. ABSTRACT Autoinflammatory diseases (AIDs) comprise a diverse group of conditions arising from dysregulated immune control due to congenital or acquired genetic abnormalities in innate immune pathways, and patients typically require lifelong treatment. Owing to their rarity, access to patient samples is limited, making … Read more

Curr Opin Immunol. 2026 Jan 13;99:102722. doi: 10.1016/j.coi.2025.102722. Online ahead of print. ABSTRACT Primary Sjögren’s disease (SjD) is a systemic autoimmune disorder where diagnosis relies on the presence of Ro/SS-A and La/SS-B autoantibodies. However, approximately one-third of SjD patients are seronegative, often requiring an invasive minor salivary gland biopsy, which can lead to significant diagnostic … Read more

Curr Opin Immunol. 2026 Jan 9;99:102718. doi: 10.1016/j.coi.2025.102718. Online ahead of print. ABSTRACT Cellular channels consisting of pannexins facilitate signaling between the intracellular and extracellular environment. In this respect, pannexin channel opening serves as a pivotal trigger for both inflammatory processes and cell death. While pannexin channels also contribute to normal physiological functions, their roles … Read more