Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, … Read more
Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key … Read more
Curr Opin Immunol. 2026 Jun 27;101:102810. doi: 10.1016/j.coi.2026.102810. Online ahead of print. ABSTRACT Ocular sarcoidosis is a frequent manifestation of sarcoidosis and may occur most commonly affecting adults between 30 and 60 years old. Uveitis may be anterior, intermediate, posterior, or present as panuveitis, with marked heterogeneity in severity and clinical course. Diagnosis relies on … Read more
Curr Opin Immunol. 2026 Jun 26;101:102808. doi: 10.1016/j.coi.2026.102808. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has renewed interest in mucosal vaccines, yet these approaches have long struggled to generate durable protection against airway pathogens. A key limitation is the incomplete understanding of how upper airway antigens are handled to shape immune response quality and … Read more
Curr Opin Immunol. 2026 Jun 23;101:102806. doi: 10.1016/j.coi.2026.102806. Online ahead of print. ABSTRACT The intestine integrates nutrient digestion and absorption with immune surveillance, being continuously challenged by dietary antigens, commensal microbiota, and pathogens. Its highly regionalized structure requires the immune system to balance tolerance to food and commensal organisms with protective responses against pathogens, generating … Read more
Curr Opin Immunol. 2026 Jun 22;101:102805. doi: 10.1016/j.coi.2026.102805. Online ahead of print. ABSTRACT Solid‑phase assays for the detection of antiphospholipid antibodies (aPL) are central to the laboratory evaluation of antiphospholipid syndrome (APS). Growing insights into the molecular immunology underlying these assays challenge traditional interpretations. It is now evident that the antigenic drivers are phospholipids (PL)‑binding … Read more
Curr Opin Immunol. 2026 Jun 16;101:102793. doi: 10.1016/j.coi.2026.102793. Online ahead of print. ABSTRACT The synovium is a critical site for the initiation and persistence of inflammatory joint diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), and gout. Conventional 2D cultures and animal models fail to recapitulate the multicellular organization, mechanical regulation, and inter-tissue communication that shape … Read more
Curr Opin Immunol. 2026 Jun 15;101:102802. doi: 10.1016/j.coi.2026.102802. Online ahead of print. ABSTRACT Lymphatic vessels maintain fluid balance and immune protection by transporting fluid, solutes and cells from tissue interstitial spaces to lymph nodes. The lymphatic endothelial cells that form lymphatics differentiate throughout the body to fulfil organ-specific roles. In the lungs, specialised pulmonary lymphatic … Read more
Curr Opin Immunol. 2026 Jun 13;101:102803. doi: 10.1016/j.coi.2026.102803. Online ahead of print. ABSTRACT Raynaud’s phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed connective … Read more
Curr Opin Immunol. 2026 Jun 4;101:102804. doi: 10.1016/j.coi.2026.102804. Online ahead of print. ABSTRACT Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by inhaling aerosolized rodent excreta, the Andes virus variant is capable of human-to-human … Read more
