Current Opinion in Immunology

Curr Opin Immunol. 2026 Apr 15;100:102775. doi: 10.1016/j.coi.2026.102775. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) presents ongoing challenges in understanding its pathogenesis, standardizing diagnostic tests, and optimizing treatment strategies. The 18th International Congress on Antiphospholipid Antibodies (ICAPA) was held in Kyoto in September 2025. This narrative meeting wrap-up summarizes selected highlights from the Congress … Read more

Curr Opin Immunol. 2026 Apr 14;100:102774. doi: 10.1016/j.coi.2026.102774. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder with a pathogenesis that includes aberrant interactions between the innate and adaptive immune systems. Dominant pathogenetic axes include the type I interferon pathway and loss of tolerance in B cell/plasma cell development with … Read more

Curr Opin Immunol. 2026 Apr 13;100:102773. doi: 10.1016/j.coi.2026.102773. Online ahead of print. ABSTRACT Autoimmune and primary immunodeficiency disorders represent a growing global health burden influenced by a complex interplay of genetic, environmental, and socioeconomic factors. This paper offers a geoepidemiological analysis of these conditions, highlighting regional differences in incidence, diagnosis, and outcomes. Immunodeficiencies such as … Read more

Curr Opin Immunol. 2026 Apr 8;100:102776. doi: 10.1016/j.coi.2026.102776. Online ahead of print. ABSTRACT Artificial intelligence (AI) and machine learning are widely promoted as transformative tools for medical practice, yet their impact in daily rheumatology remains limited. This review examines the gap between expectations and reality using historical parallels, conceptual considerations, and recent methodological evidence. Experiences … Read more

Curr Opin Immunol. 2026 Apr 8;100:102772. doi: 10.1016/j.coi.2026.102772. Online ahead of print. ABSTRACT This paper reviews the historical development, pathogenesis, and nomenclature of Sjögren’s syndrome and critiques the recently proposed term ‘Sjögren’s disease’. Early clinical observations gradually defined the disorder as a systemic condition characterized by sicca symptoms and frequent extraglandular involvement. Advances in immunology … Read more

Curr Opin Immunol. 2026 Apr 7;100:102771. doi: 10.1016/j.coi.2026.102771. Online ahead of print. ABSTRACT Identified in the 1990s as the primary target of antiphospholipid antibodies (aPL) in antiphospholipid syndrome (APS), β2-glycoprotein I (β2GPI) remains a central focus in hematology and immunology. Anti-β2GPI antibodies are important not only for diagnosing APS but also play a key role … Read more

Curr Opin Immunol. 2026 Apr 2;100:102769. doi: 10.1016/j.coi.2026.102769. Online ahead of print. ABSTRACT Although immunometabolism has emerged as a central area of research in infectious diseases, only a few studies have focused on Plasmodium vivax infection. Here, we discuss the results obtained in our laboratory and elsewhere that show a metabolic-mitochondria shift in highly activated … Read more

Curr Opin Immunol. 2026 Mar 30;100:102759. doi: 10.1016/j.coi.2026.102759. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is increasingly recognised as a multifactorial and heterogeneous condition rather than a single uniform disorder, supported by advances in molecular biology, genetics and pathology. This review provides a perspective on the shifting concept of PD from an idiopathic, strictly … Read more

Curr Opin Immunol. 2026 Mar 28;100:102761. doi: 10.1016/j.coi.2026.102761. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is increasingly understood as a systemic disorder with early manifestations outside the central nervous system. Converging clinical, metabolic, and immunological observations highlight overlaps between PD and primary biliary cholangitis (PBC), a prototypic autoimmune cholestatic liver disease. A shared hallmark … Read more

Curr Opin Immunol. 2026 Mar 26;100:102768. doi: 10.1016/j.coi.2026.102768. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disorder in which antiphospholipid antibodies cause vascular thrombosis and obstetric morbidity. Growing evidence indicates that neutrophils and monocytes are key effector cells bridging inflammation and coagulation in APS. Neutrophils display heightened activation, enhanced glycolysis, and … Read more