Current Opinion in Immunology

Curr Opin Immunol. 2025 Aug 26;96:102650. doi: 10.1016/j.coi.2025.102650. Online ahead of print. ABSTRACT Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving clinicians struggling to fully understand and manage it due to its unpredictable … Read more

Curr Opin Immunol. 2025 Aug 26;96:102649. doi: 10.1016/j.coi.2025.102649. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves systemic corticosteroids, but many patients do not respond adequately, with 30%-50% of patients being … Read more

Curr Opin Immunol. 2025 Aug 25;96:102647. doi: 10.1016/j.coi.2025.102647. Online ahead of print. ABSTRACT The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG+ neuromyelitis optica (NMO) and myelin oligodendrocyte … Read more

Curr Opin Immunol. 2025 Aug 21;96:102646. doi: 10.1016/j.coi.2025.102646. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immunomodulation (TRIM), highlighting how biochemical changes in stored blood products – with a focus on packed red blood cells – affect recipient immune responses. RECENT … Read more

Curr Opin Immunol. 2025 Aug 20;96:102639. doi: 10.1016/j.coi.2025.102639. Online ahead of print. ABSTRACT Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as key molecular players. Serotonin, a tryptophan-derived neurochemical found across the kingdom of life, is increasingly … Read more

Curr Opin Immunol. 2025 Aug 20;96:102644. doi: 10.1016/j.coi.2025.102644. Online ahead of print. ABSTRACT Allergic transfusion reactions (ATRs) are among the most common adverse nonhemolytic transfusion reactions. However, since ATR is diagnosed based only on clinical observations, contrary to other allergic diseases, the causal relationship between a given ATR and the corresponding transfusion remains ambiguous in … Read more

Curr Opin Immunol. 2025 Aug 19;96:102645. doi: 10.1016/j.coi.2025.102645. Online ahead of print. ABSTRACT The rising interest in using cold-stored platelets (CSP) for improving outcomes in patients with active bleeding has led to multiple clinical trials with the goal of determining the in vivo hemostatic efficacy of CSP compared to standard-of-care room temperature-stored platelets. These trials … Read more

Curr Opin Immunol. 2025 Aug 18;96:102641. doi: 10.1016/j.coi.2025.102641. Online ahead of print. ABSTRACT Psoriasis and psoriatic arthritis are chronic autoimmune diseases characterized by dysregulated immune responses, particularly involving Th17 cells. Immune checkpoint molecules such as programmed death-1 (PD-1) and its ligands (PD-L1/PD-L2) are critical for maintaining immune tolerance. Disruptions in these pathways contribute to psoriatic … Read more

Curr Opin Immunol. 2025 Aug 18;96:102642. doi: 10.1016/j.coi.2025.102642. Online ahead of print. ABSTRACT Patients with chronic kidney disease (CKD), especially those with end-stage kidney disease on dialysis or kidney transplant recipients (KTRs), are highly susceptible to infections, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic disproportionately affected this vulnerable population, … Read more

Curr Opin Immunol. 2025 Aug 14;96:102640. doi: 10.1016/j.coi.2025.102640. Online ahead of print. ABSTRACT A general understanding of the mechanisms leading to the development of systemic lupus has emerged over recent years, yet treatment of the illness remains largely empiric and unsatisfactory. Targeted therapy with monoclonal antibodies directed against B cells and against cytokines has met … Read more