Current Opinion in Immunology

Curr Opin Immunol. 2025 Jun 24;95:102596. doi: 10.1016/j.coi.2025.102596. Online ahead of print. ABSTRACT Autoimmune diseases represent a significant global health burden, characterized by aberrant immune responses leading to tissue damage and functional impairment. Despite advancements in immunosuppressive therapies, achieving sustained remission remains challenging, necessitating innovative therapeutic approaches. Chimeric antigen receptor (CAR) T cell therapy, a … Read more

Curr Opin Immunol. 2025 Jun 23;95:102591. doi: 10.1016/j.coi.2025.102591. Online ahead of print. ABSTRACT Pemphigus and bullous pemphigoid (BP) are both autoimmune bullous diseases (AIBD), but their clinical features and treatment strategies are different. Pemphigus is characterized by intraepidermal blisters mediated by antibodies against desmosomes, while BP is characterized by subepidermal blisters mediated by antibodies against … Read more

Curr Opin Immunol. 2025 Jun 23;95:102590. doi: 10.1016/j.coi.2025.102590. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disease whose main manifestation is scaly and erythematous plaques. The pathogenesis is complex, including genetic and environmental factors. In recent years, epigenetic modifications, which means changing in gene expression instead of altering the DNA sequence, have … Read more

Curr Opin Immunol. 2025 Jun 19;95:102587. doi: 10.1016/j.coi.2025.102587. Online ahead of print. ABSTRACT Psoriatic arthritis (PsA) is a systemic, immune-mediated disorder characterized by inflammation across peripheral and axial joints, entheses, skin, and nails. Given this heterogeneous manifestation, PsA presents unique challenges in clinical diagnosis and management. Conventional imaging, limited to localized, anatomical assessments, often fails … Read more

Curr Opin Immunol. 2025 Jun 19;95:102588. doi: 10.1016/j.coi.2025.102588. Online ahead of print. ABSTRACT Supporting the health and function of the central nervous system (CNS), the choroid plexus (CP) not only produces cerebrospinal fluid, but it also facilitates brain-immune interfacing, removes waste, and secretes proneuronal signals. Despite these key physiological contributions, a pathogenic role for the … Read more

Curr Opin Immunol. 2025 Jun 19;95:102589. doi: 10.1016/j.coi.2025.102589. Online ahead of print. ABSTRACT Autoimmune bullous diseases (AIBDs), including pemphigus and pemphigoid, are featured as the presence of autoantibodies directed against structural proteins, resulting in severe blistering as well as considerable morbidity. Current treatments, including glucocorticoids, immunomodulators, and biologics, often fail to achieve sustained remission due … Read more

Curr Opin Immunol. 2025 Jun 20;95:102595. doi: 10.1016/j.coi.2025.102595. Online ahead of print. ABSTRACT Healthy individuals exhibit sex-specific immune responses. In certain immune-related diseases, such as autoimmune diseases, there is a pronounced sex bias in incidence, severity, and other clinical features. These differences are influenced by immune-related genes encoded in the sex chromosomes, as well as … Read more

Curr Opin Immunol. 2025 Jun 18;95:102593. doi: 10.1016/j.coi.2025.102593. Online ahead of print. ABSTRACT Chronic intestinal inflammation in inflammatory bowel diseases (IBD) reflects the interplay of genetic predisposition, immune dysregulation, microbial imbalance, and epithelial barrier defects. Current therapies for IBD primarily focus on controlling inflammation necessitating lifelong treatment and face a ‘therapeutic ceiling’ due to primary … Read more

Curr Opin Immunol. 2025 Jun 17;95:102592. doi: 10.1016/j.coi.2025.102592. Online ahead of print. ABSTRACT Autoimmune diseases (AIDs) comprise a highly heterogeneous group of disorders with significant morbidity, disability, and mortality. Growing scientific evidence has suggested the interactions between genetic and environmental factors robustly involving in the pathogenesis of AIDs. Epigenetics serves as a critical bridge linking … Read more

Curr Opin Immunol. 2025 Feb;92:102524. doi: 10.1016/j.coi.2024.102524. Epub 2024 Dec 27. ABSTRACT The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early … Read more