Current Opinion in Immunology

Curr Opin Immunol. 2026 Aug 3;102:102832. doi: 10.1016/j.coi.2026.102832. Online ahead of print. ABSTRACT Real-world data (RWD) from nonrandomized clinical settings, such as registries and observational cohorts, can be used to address research questions for which randomized controlled trials (RCTs) are not feasible or appropriate. However, these data are susceptible to important sources of bias, including … Read more

Curr Opin Immunol. 2026 Jul 31;102:102833. doi: 10.1016/j.coi.2026.102833. Online ahead of print. ABSTRACT Recurrent pericarditis complicates approximately one-third of initial pericarditis episodes in children. Once considered a postinfectious sequel, it is now understood as an autoinflammatory disorder sustained by dysregulated interleukin-1 signaling and inflammasome hyperactivation. This review evaluates therapeutic strategies for idiopathic recurrent pericarditis in … Read more

Curr Opin Immunol. 2026 Jul 30;102:102814. doi: 10.1016/j.coi.2026.102814. Online ahead of print. ABSTRACT Spatial transcriptomic and proteomic atlases have enabled mapping of gene programs within intact tissues, but these measurements remain largely descriptive and do not define the mechanisms controlling tissue biology. Pooled CRISPR screening provides scalable causal interrogation of gene function but remains largely … Read more

Curr Opin Immunol. 2026 Jul 29;102:102829. doi: 10.1016/j.coi.2026.102829. Online ahead of print. ABSTRACT Tumors are spatially heterogeneous ecosystems in which malignant, stromal, vascular, and immune cells interact within metabolically distinct niches. These localized microenvironments are shaped by factors such as nutrient availability, hypoxia, acidosis, and immunomodulatory metabolites, all of which strongly influence CD8⁺ T cell … Read more

Curr Opin Immunol. 2026 Jul 28;102:102830. doi: 10.1016/j.coi.2026.102830. Online ahead of print. ABSTRACT Over the last two years, inflammatory dermatology has undergone a transition from morphology-based classification toward pathway-driven immune endotyping. Atopic dermatitis, psoriatic disease, and hidradenitis suppurativa have emerged as paradigmatic models of this transition, illustrating how epithelial dysfunction, involving autoinflammation and adaptive immunity, … Read more

Curr Opin Immunol. 2026 Jul 27;102:102831. doi: 10.1016/j.coi.2026.102831. Online ahead of print. ABSTRACT Cardiac sarcoidosis is a potentially fatal inflammatory disorder with the tendency to mostly affect the myocardial tissues. It is commonly associated with extra-cardiac structures such as the lungs and the thoracic lymph nodes; however, when it manifests as an isolated disease, it … Read more

Curr Opin Immunol. 2026 Jul 24;102:102828. doi: 10.1016/j.coi.2026.102828. Online ahead of print. ABSTRACT Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and were long regarded as inert remnants of ancestral retroviral infections. Increasing evidence indicates that HERVs are active genomic elements capable of influencing transcriptional programs, modulating immune responses, and contributing to … Read more

Curr Opin Immunol. 2026 Jul 23;102:102820. doi: 10.1016/j.coi.2026.102820. Online ahead of print. ABSTRACT Once considered incurable, psoriasis is now being re-evaluated in light of sustained, drug-free remissions, prompting a redefinition of ‘cure’ as long-term/drug-free remission. Psoriatic disease is primarily driven by dysregulation of the interleukin-23 (IL-23)/IL-17 axis, and the survival of tissue-resident memory T cells … Read more

Curr Opin Immunol. 2026 Jul 22;102:102819. doi: 10.1016/j.coi.2026.102819. Online ahead of print. ABSTRACT Microglia are the resident innate immune cells of the brain that play essential roles in immune surveillance, phagocytosis, and neuroinflammatory responses. A central regulator of these diverse functions is intracellular Ca2+ signaling, which connects extracellular cues to transcriptional and metabolic programs that … Read more

Curr Opin Immunol. 2026 Jul 20;102:102818. doi: 10.1016/j.coi.2026.102818. Online ahead of print. ABSTRACT The development of clinical trials is limited by high costs and methodological complexities. In this context, artificial intelligence (AI) is emerging as a key instrument for their optimization. In the early phases of study design and recruiting, generative AI systems may help … Read more