Current Opinion in Immunology

Curr Opin Immunol. 2025 Oct 10;97:102676. doi: 10.1016/j.coi.2025.102676. Online ahead of print. ABSTRACT Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also induce, in 30-50% of the patients, acute graft-versus-host disease (aGvHD), a severe condition … Read more

Curr Opin Immunol. 2025 Oct 10;97:102675. doi: 10.1016/j.coi.2025.102675. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) can cure patients with high-risk hematologic malignancies. Donor T and natural killer (NK) cells contribute to graft-versus-leukemia (GVL) effects that provide relapse protection. Post-HCT relapses often represent inadequate GVL, but alloreactive lymphocytes that confer GVL may also … Read more

Curr Opin Immunol. 2025 Oct 9;97:102674. doi: 10.1016/j.coi.2025.102674. Online ahead of print. ABSTRACT Psoriasis is a chronic immune-mediated skin disease whose inflammation can affect other systems and lead to various comorbidities. As a model inflammatory skin disease, while advances in mechanistic insights and targeted therapies have improved outcomes, unmet clinical needs persist. Modern technologies like … Read more

Curr Opin Immunol. 2025 Oct 9;97:102677. doi: 10.1016/j.coi.2025.102677. Online ahead of print. ABSTRACT A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are a prime example – respiratory viruses present a threat to their target cells, the epithelial cells that line the airways, but excessive leukocyte … Read more

Curr Opin Immunol. 2025 Oct 4;97:102673. doi: 10.1016/j.coi.2025.102673. Online ahead of print. ABSTRACT Cutaneous involvement of sarcoidosis can provide important insights into the presence and prognosis of systemic involvement. Recent insights into the underlying pathophysiology of sarcoidosis have allowed for more targeted therapy, including inhibition of the JAK-STAT and mTOR pathways. In this review article, … Read more

Curr Opin Immunol. 2025 Sep 30;97:102661. doi: 10.1016/j.coi.2025.102661. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal tract that arises from a complex interplay between a dysregulated immune response in genetically predisposed individuals. IBD can further be classified into its two main subtypes, Crohn’s disease and ulcerative colitis. … Read more

Curr Opin Immunol. 2025 Sep 22;97:102659. doi: 10.1016/j.coi.2025.102659. Online ahead of print. ABSTRACT BACKGROUND: During the SARS-CoV-2 pandemic, we described a peak of a Kawasaki-like disease in children, later renamed multisystem inflammatory syndrome in children (MIS-C). We report the long-term outcomes of MIS-C patients who presented to our center. METHODS: We recorded clinical features and … Read more

Curr Opin Immunol. 2025 Sep 19;97:102663. doi: 10.1016/j.coi.2025.102663. Online ahead of print. ABSTRACT Sarcoidosis is a complex, polygenic, and multifactorial disease characterized by granulomas in affected organs, which are the hallmark of the condition. Genetic susceptibility, environmental influences, and lifestyle factors play key roles in its development. Although the exact molecular mechanisms are not yet … Read more

Curr Opin Immunol. 2025 Sep 19;97:102662. doi: 10.1016/j.coi.2025.102662. Online ahead of print. ABSTRACT Since its first application in HLA-haploidentical settings, post-transplant cyclophosphamide (PTCy) has become a standard for graft-versus-host disease (GVHD) prophylaxis, with its use expanding to matched and mismatched hematopoietic cell transplantation. Its major clinical advantages include versatility and cost-effectiveness, providing robust GVHD prevention … Read more

Curr Opin Immunol. 2025 Sep 17;97:102660. doi: 10.1016/j.coi.2025.102660. Online ahead of print. ABSTRACT The dogma of an impenetrable blood-brain barrier (BBB) has given way to the view that resident immune cells within the central nervous system respond to a variety of blood-borne soluble factors, particularly cytokines, and play an important functional role. In particular, microglia … Read more