Curr Opin Immunol. 2026 Jan 22;99:102724. doi: 10.1016/j.coi.2026.102724. Online ahead of print. ABSTRACT As of 2024, the World Health Organization declared the Zika virus (ZIKV), an emerging flavivirus, as a high-priority pathogen with the potential to cause future Public Health Emergencies of International Concern. Although the last major outbreak of ZIKV occurred in 2015-2016, ongoing … Read more
Curr Opin Immunol. 2026 Jan 22;99:102725. doi: 10.1016/j.coi.2026.102725. Online ahead of print. ABSTRACT We report on 13 classic infantile Pompe patients, including four cross-reactive immunological material negative (31%), treated with alglucosidase alpha (rhGAA) at Fondazione IRCCS San Gerardo, Monza, between 2003 and 2024. Median age at rhGAA initiation was 3.3 months, with nine patients (69%) … Read more
Curr Opin Immunol. 2026 Jan 14;99:102720. doi: 10.1016/j.coi.2025.102720. Online ahead of print. ABSTRACT Patients with sarcoidosis can present with a wide range of symptoms that impact their quality of life (QoL). QoL represents one of the most important treatment priorities for patients. Therefore, measuring what matters to patients is of great importance, though it can … Read more
Curr Opin Immunol. 2026 Jan 13;99:102721. doi: 10.1016/j.coi.2025.102721. Online ahead of print. ABSTRACT Elderly-onset rheumatoid arthritis (EORA), defined as onset at ≥60 years, is a clinically distinct and increasingly prevalent subset of rheumatoid arthritis (RA). This review synthesizes evidence that EORA is not merely late-onset RA but a pathogenically unique entity, driven by immune aging, … Read more
Curr Opin Immunol. 2026 Jan 13;99:102719. doi: 10.1016/j.coi.2025.102719. Online ahead of print. ABSTRACT Autoinflammatory diseases (AIDs) comprise a diverse group of conditions arising from dysregulated immune control due to congenital or acquired genetic abnormalities in innate immune pathways, and patients typically require lifelong treatment. Owing to their rarity, access to patient samples is limited, making … Read more
Curr Opin Immunol. 2026 Jan 13;99:102722. doi: 10.1016/j.coi.2025.102722. Online ahead of print. ABSTRACT Primary Sjögren’s disease (SjD) is a systemic autoimmune disorder where diagnosis relies on the presence of Ro/SS-A and La/SS-B autoantibodies. However, approximately one-third of SjD patients are seronegative, often requiring an invasive minor salivary gland biopsy, which can lead to significant diagnostic … Read more
Curr Opin Immunol. 2026 Jan 9;99:102718. doi: 10.1016/j.coi.2025.102718. Online ahead of print. ABSTRACT Cellular channels consisting of pannexins facilitate signaling between the intracellular and extracellular environment. In this respect, pannexin channel opening serves as a pivotal trigger for both inflammatory processes and cell death. While pannexin channels also contribute to normal physiological functions, their roles … Read more
Curr Opin Immunol. 2026 Jan 9;99:102714. doi: 10.1016/j.coi.2025.102714. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic, heterogeneous autoimmune disorder, clinically dominated by dryness symptoms resulting from inflammatory infiltration of exocrine glands. To date, no validated and resolutive therapeutic strategies are available. Stromal cells are increasingly recognized as critical players in SjD pathogenesis. … Read more
Curr Opin Immunol. 2026 Jan 9;99:102715. doi: 10.1016/j.coi.2025.102715. Online ahead of print. ABSTRACT Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to result from an abnormal immune response triggered by environmental agents in … Read more
Curr Opin Immunol. 2026 Jan 8;99:102717. doi: 10.1016/j.coi.2025.102717. Online ahead of print. ABSTRACT We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify corresponding unmet needs and future perspectives. First, we briefly describe the mechanisms of lymphomagenesis in SjD. Followingly, the reasons justifying the importance of … Read more
