Current Opinion in Immunology

Curr Opin Immunol. 2024 Dec 5;92:102509. doi: 10.1016/j.coi.2024.102509. Online ahead of print. ABSTRACT Allergies result from an antigen-specific loss of tolerance against innocuous foreign substances. Allergen immunotherapy (AIT) aims to reverse the pathogenic response and to re-establish physiological tolerance. However, the tolerogenic mechanisms that prevent allergy in healthy and act during AIT are still obscure. … Read more

Curr Opin Immunol. 2024 Dec 4;92:102508. doi: 10.1016/j.coi.2024.102508. Online ahead of print. ABSTRACT Tuberculosis is caused by Mycobacterium tuberculosis, a bacterium that accounts for more human mortality than any other. Evidence is accumulating for the view that tuberculosis is an interferonopathy – a disease driven by type I interferons. However, how type I interferons exacerbate … Read more

Curr Opin Immunol. 2024 Nov 25;92:102506. doi: 10.1016/j.coi.2024.102506. Online ahead of print. ABSTRACT Accumulating evidence demonstrates that tumor-specific CD8+ T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8+ T (TPEX) cells and newly defined tumor-specific memory subsets … Read more

Curr Opin Immunol. 2024 Nov 22;91:102507. doi: 10.1016/j.coi.2024.102507. Online ahead of print. ABSTRACT The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions … Read more

Curr Opin Immunol. 2024 Nov 19;91:102505. doi: 10.1016/j.coi.2024.102505. Online ahead of print. ABSTRACT Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and … Read more

Curr Opin Immunol. 2024 Nov 14;91:102504. doi: 10.1016/j.coi.2024.102504. Online ahead of print. ABSTRACT The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell … Read more

Curr Opin Immunol. 2024 Nov 12;91:102502. doi: 10.1016/j.coi.2024.102502. Online ahead of print. ABSTRACT Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. … Read more

Curr Opin Immunol. 2024 Nov 9;91:102501. doi: 10.1016/j.coi.2024.102501. Online ahead of print. ABSTRACT Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, … Read more

Curr Opin Immunol. 2024 Nov 8;91:102503. doi: 10.1016/j.coi.2024.102503. Online ahead of print. ABSTRACT Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, … Read more

Curr Opin Immunol. 2024 Oct 31;91:102499. doi: 10.1016/j.coi.2024.102499. Online ahead of print. ABSTRACT As cancer immunotherapy evolves, tissue-resident memory (TRM) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal … Read more