Current Opinion in Immunology

Curr Opin Immunol. 2025 Sep 11;97:102656. doi: 10.1016/j.coi.2025.102656. Online ahead of print. ABSTRACT SARS-CoV-2 infection and vaccination are associated with a broad range of skin manifestations, including chilblains, urticaria, morbilliform and papulovesicular rashes, purpuric-necrotic lesions, and autoimmune flares. These patterns reflect differences in the timing and nature of type I interferon (IFN-I) responses. Rapid TLR7-mediated … Read more

Curr Opin Immunol. 2025 Sep 9;97:102654. doi: 10.1016/j.coi.2025.102654. Online ahead of print. ABSTRACT Glucocorticoid-refractory chronic graft-versus-host disease (glucocorticoid-refractory cGVHD) remains a major barrier to long-term survival and quality of life following allogeneic hematopoietic stem cell transplantation (allo-HSCT), affecting 30-70% to half of patients with chronic GVHD who fail corticosteroid therapy. In recent years, the Food … Read more

Curr Opin Immunol. 2025 Sep 5;97:102655. doi: 10.1016/j.coi.2025.102655. Online ahead of print. ABSTRACT The complement system plays a paradoxical role in systemic lupus erythematosus physiopathology, acting both as a protective mechanism and as a driver of tissue injury, depending on disease stage. Neutrophil extracellular traps (NETs) further exacerbate disease activity by promoting complement activation and … Read more

Curr Opin Immunol. 2025 Sep 3;97:102653. doi: 10.1016/j.coi.2025.102653. Online ahead of print. ABSTRACT C1 Inhibitor (C1INH) is a crucial regulator of multiple plasmatic pathways, including complement, coagulation, kallikrein-kinin systems, and fibrinolysis. C1INH deficiency results in the downstream overproduction of the vasoactive peptide bradykinin (BK), the primary mediator of angioedema (AE), a rare disease characterized by … Read more

Curr Opin Immunol. 2025 Sep 2;97:102651. doi: 10.1016/j.coi.2025.102651. Online ahead of print. ABSTRACT ‘Intrinsic immunity’ is often used to refer to mechanisms of host defense operating in nonleukocytic cells. This term can refer to the intrinsic capacity of an individual cell to fend off invading microbes without help from other cells or of a group … Read more

Curr Opin Immunol. 2025 Sep 1;97:102652. doi: 10.1016/j.coi.2025.102652. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Diagnosing sarcoidosis remains challenging. Histology findings and a variable clinical presentation can mimic other infectious, malignant, and autoimmune diseases. This review synthesizes current evidence on histopathology, sampling techniques, imaging modalities, and biomarkers and explores how emerging ‘omics’ and artificial … Read more

Curr Opin Immunol. 2025 Aug 29;97:102648. doi: 10.1016/j.coi.2025.102648. Online ahead of print. ABSTRACT Endothelial cells (ECs) integrate immune and vascular functions to promote host defense against pathogens. While previously studied as forming passive flow conduits, ECs are now recognized as active contributors to maladaptive inflammation. During acute infection, ECs may promote tissue pathologies, including hypoxia, … Read more

Curr Opin Immunol. 2025 Aug 26;96:102650. doi: 10.1016/j.coi.2025.102650. Online ahead of print. ABSTRACT Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving clinicians struggling to fully understand and manage it due to its unpredictable … Read more

Curr Opin Immunol. 2025 Aug 26;96:102649. doi: 10.1016/j.coi.2025.102649. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves systemic corticosteroids, but many patients do not respond adequately, with 30%-50% of patients being … Read more

Curr Opin Immunol. 2025 Aug 25;96:102647. doi: 10.1016/j.coi.2025.102647. Online ahead of print. ABSTRACT The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG+ neuromyelitis optica (NMO) and myelin oligodendrocyte … Read more