Curr Opin Immunol. 2025 Aug 21;96:102646. doi: 10.1016/j.coi.2025.102646. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immunomodulation (TRIM), highlighting how biochemical changes in stored blood products – with a focus on packed red blood cells – affect recipient immune responses. RECENT … Read more
Curr Opin Immunol. 2025 Aug 20;96:102639. doi: 10.1016/j.coi.2025.102639. Online ahead of print. ABSTRACT Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as key molecular players. Serotonin, a tryptophan-derived neurochemical found across the kingdom of life, is increasingly … Read more
Curr Opin Immunol. 2025 Aug 20;96:102644. doi: 10.1016/j.coi.2025.102644. Online ahead of print. ABSTRACT Allergic transfusion reactions (ATRs) are among the most common adverse nonhemolytic transfusion reactions. However, since ATR is diagnosed based only on clinical observations, contrary to other allergic diseases, the causal relationship between a given ATR and the corresponding transfusion remains ambiguous in … Read more
Curr Opin Immunol. 2025 Aug 19;96:102645. doi: 10.1016/j.coi.2025.102645. Online ahead of print. ABSTRACT The rising interest in using cold-stored platelets (CSP) for improving outcomes in patients with active bleeding has led to multiple clinical trials with the goal of determining the in vivo hemostatic efficacy of CSP compared to standard-of-care room temperature-stored platelets. These trials … Read more
Curr Opin Immunol. 2025 Aug 18;96:102641. doi: 10.1016/j.coi.2025.102641. Online ahead of print. ABSTRACT Psoriasis and psoriatic arthritis are chronic autoimmune diseases characterized by dysregulated immune responses, particularly involving Th17 cells. Immune checkpoint molecules such as programmed death-1 (PD-1) and its ligands (PD-L1/PD-L2) are critical for maintaining immune tolerance. Disruptions in these pathways contribute to psoriatic … Read more
Curr Opin Immunol. 2025 Aug 18;96:102642. doi: 10.1016/j.coi.2025.102642. Online ahead of print. ABSTRACT Patients with chronic kidney disease (CKD), especially those with end-stage kidney disease on dialysis or kidney transplant recipients (KTRs), are highly susceptible to infections, including the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic disproportionately affected this vulnerable population, … Read more
Curr Opin Immunol. 2025 Aug 14;96:102640. doi: 10.1016/j.coi.2025.102640. Online ahead of print. ABSTRACT A general understanding of the mechanisms leading to the development of systemic lupus has emerged over recent years, yet treatment of the illness remains largely empiric and unsatisfactory. Targeted therapy with monoclonal antibodies directed against B cells and against cytokines has met … Read more
Curr Opin Immunol. 2025 Aug 14;96:102643. doi: 10.1016/j.coi.2025.102643. Online ahead of print. ABSTRACT Autoimmune skin diseases (AISDs) constitute a group of skin disorders driven by B cell-mediated autoimmunity or dysregulation of other immune cell populations. AISD can be further divided into systemic autoimmune disease with skin involvement, such as systemic lupus erythematosus (SLE), and skin-specific … Read more
Curr Opin Immunol. 2025 Aug 14;96:102636. doi: 10.1016/j.coi.2025.102636. Online ahead of print. ABSTRACT Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears … Read more
Curr Opin Immunol. 2025 Aug 11;96:102632. doi: 10.1016/j.coi.2025.102632. Online ahead of print. ABSTRACT Juvenile idiopathic arthritis (JIA) is the most common rheumatological disorder affecting children. It is characterized by chronic synovial inflammation that may lead to permanent joint damage and disability. JIA is an umbrella term for a heterogenous group of subtypes based on specific … Read more
