Curr Opin Immunol. 2025 Feb 26;93:102541. doi: 10.1016/j.coi.2025.102541. Online ahead of print. ABSTRACT The nervous system, like the immune system, constantly interfaces with the environment, encountering threats, including pathogens. Recent discoveries reveal an emerging role for sensory neurons in host defense and immunity. Sensory neurons detect infections either by directly sensing microbial signals or through … Read more

Curr Opin Immunol. 2025 Feb 5;93:102536. doi: 10.1016/j.coi.2025.102536. Online ahead of print. ABSTRACT Tissues deliver not only antigens and cells via afferent lymphatics to draining lymph nodes during immune responses but also deliver soluble molecules that reflect the state of the tissue. In autoimmune diseases, these signals from affected tissues can potentially impact the magnitude … Read more

Curr Opin Immunol. 2025 Jan 30;93:102535. doi: 10.1016/j.coi.2025.102535. Online ahead of print. ABSTRACT The key role of nucleic acid sensing receptors in the development of autoimmune and autoinflammatory diseases is becoming increasingly apparent. Activation of these sensors has been attributed to the failure of professional scavenger cells to adequately clear cell debris, in many cases … Read more

Curr Opin Immunol. 2025 Jan 18;93:102525. doi: 10.1016/j.coi.2025.102525. Online ahead of print. ABSTRACT Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is especially critical in the complex environment of the bone marrow (BM), where there is a need to both preserve the quiescence of hematopoietic stem cells (HSCs) … Read more

Curr Opin Immunol. 2024 Dec 16;92:102523. doi: 10.1016/j.coi.2024.102523. Online ahead of print. NO ABSTRACT PMID:39689416 | DOI:10.1016/j.coi.2024.102523

Curr Opin Immunol. 2024 Dec 14;92:102512. doi: 10.1016/j.coi.2024.102512. Online ahead of print. ABSTRACT Noncanonical inflammasomes are instrumental in defense against Gram-negative bacteria, activated primarily by bacterial lipopolysaccharide. This review examines commonalities and distinctions in noncanonical inflammasome activation either by virulence factor activity indicating cellular invasion or by detection of bacterial mRNA signaling the undesired presence … Read more

Curr Opin Immunol. 2024 Dec 14;92:102513. doi: 10.1016/j.coi.2024.102513. Online ahead of print. ABSTRACT This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France. PMID:39675153 | … Read more

Curr Opin Immunol. 2024 Dec 12;92:102511. doi: 10.1016/j.coi.2024.102511. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation, stability, proliferation, and suppressive function. Enhancing Treg metabolism to boost their suppressive … Read more

Curr Opin Immunol. 2024 Dec 10;92:102510. doi: 10.1016/j.coi.2024.102510. Online ahead of print. ABSTRACT Local regulation of T cell-mediated immunity to solid tumors occurs at multiple levels, including their recruitment from the bloodstream to the tumor microenvironment (TME), coordinated crosstalk with different subsets of antigen-presenting cells (APCs) controlling their local survival, proliferation, and effector differentiation, as … Read more

Curr Opin Immunol. 2024 Dec 5;92:102509. doi: 10.1016/j.coi.2024.102509. Online ahead of print. ABSTRACT Allergies result from an antigen-specific loss of tolerance against innocuous foreign substances. Allergen immunotherapy (AIT) aims to reverse the pathogenic response and to re-establish physiological tolerance. However, the tolerogenic mechanisms that prevent allergy in healthy and act during AIT are still obscure. … Read more