Curr Opin Immunol. 2025 Aug 9;96:102637. doi: 10.1016/j.coi.2025.102637. Online ahead of print. ABSTRACT Sarcoidosis is a systemic granulomatous disease of unknown cause that affects the lungs almost invariably. The clinical course and outcomes of pulmonary sarcoidosis are highly variable, ranging from mild and self-limiting to organ-threatening or life-threatening disease. Often, sarcoidosis remits permanently (spontaneously or … Read more
Curr Opin Immunol. 2025 Aug 7;96:102638. doi: 10.1016/j.coi.2025.102638. Online ahead of print. ABSTRACT Tuning complement activity is essential to maximize therapeutic efficacy while minimizing off-target effects in monoclonal antibody (mAb) design. Complement-enhancing strategies are primarily applied to mAbs targeting pathogens, infected cells, tumors, or immunosuppressive cells within the tumor microenvironment. In contrast, complement-silencing strategies are … Read more
Curr Opin Immunol. 2025 Aug 6;96:102629. doi: 10.1016/j.coi.2025.102629. Online ahead of print. ABSTRACT Macrophages and the complement system are fundamental components of innate immunity, emerging early in evolutionary history. The well-established functions of complement in relation to macrophages contribute to both innate and adaptive immunity and are mediated by extracellular components acting systemically or locally … Read more
Curr Opin Immunol. 2025 Aug 6;96:102628. doi: 10.1016/j.coi.2025.102628. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia. Complement system, which shares common actors with the coagulation cascade, is nowadays well established to be implicated in APS pathophysiology by different mechanisms. In APS, complement activation assessment is not included in the routine … Read more
Curr Opin Immunol. 2025 Aug 6;96:102631. doi: 10.1016/j.coi.2025.102631. Online ahead of print. ABSTRACT Neuropsychiatric lupus (NPSLE) is believed to manifest in 30-40% of SLE patients, with symptoms spanning from fatigue and anxiety to depression, cognitive impairment, and psychosis. Over the past decades, it has become clear that most animal models of SLE also present with … Read more
Curr Opin Immunol. 2025 Aug 5;96:102635. doi: 10.1016/j.coi.2025.102635. Online ahead of print. ABSTRACT Wound healing represents a dynamic process centered on the temporally coordinated inflammatory, proliferative, and remodeling phases. The inflammatory response exhibits a double-edged role: a moderate response is essential for normal healing, but excessive or persistent response impedes repair processes. In normal wound … Read more
Curr Opin Immunol. 2025 Aug 5;96:102610. doi: 10.1016/j.coi.2025.102610. Online ahead of print. ABSTRACT Antiphospholipid antibody syndrome (APS) is a vasculopathy with recurrent thrombosis and/or miscarriages mediated by autoantibodies against PL-binding proteins (aPL), mainly beta2glycoprotein I (β2GPI). While clotting is the key in vascular APS, thrombosis is not critical for placenta pathology. Despite that, anticoagulant/antiplatelet drugs … Read more
Curr Opin Immunol. 2025 Aug 5;96:102634. doi: 10.1016/j.coi.2025.102634. Online ahead of print. ABSTRACT Alloimmunization to blood group antigens is the result of a humoral immune response initiated by exposure to foreign antigens absent from the recipient’s red blood cells (RBCs). Interestingly, not all individuals who receive mismatched RBC transfusions develop alloantibodies. Increasing evidence points to … Read more
Curr Opin Immunol. 2025 Aug 5;96:102633. doi: 10.1016/j.coi.2025.102633. Online ahead of print. ABSTRACT The complement system, a central component of innate immunity, is implicated in tumor biology, influencing processes such as tumor progression, immune evasion, and response to therapy. Numerous studies have identified alterations in complement effectors, activation products, regulatory proteins, and receptors in patients … Read more
Curr Opin Immunol. 2025 Aug 1;96:102630. doi: 10.1016/j.coi.2025.102630. Online ahead of print. ABSTRACT Inflammatory memory refers to the ability of an organism to mount a stronger or faster response upon re-exposure to similar inflammatory stimuli. This heightened sensitivity was once thought to be a unique characteristic of immune cells. However, recent studies have challenged this … Read more
