Current Opinion in Immunology

Curr Opin Immunol. 2025 Jul 2;95:102594. doi: 10.1016/j.coi.2025.102594. Online ahead of print. ABSTRACT Over recent decades, the significance of autoantibodies has been increasingly recognized in neurological diseases. Breakthroughs, such as the identification of pathogenic autoantibodies targeting aquaporin-4 in central nervous system demyelinating disorders and N-methyl-D-aspartate receptors in autoimmune encephalitis, have revolutionized both the discovery and … Read more

Curr Opin Immunol. 2025 Jul 2;95:102600. doi: 10.1016/j.coi.2025.102600. Online ahead of print. ABSTRACT Exhausted CD8+T cells (CD8+Tex), characterized by progressive dysfunction and sustained inhibitory receptor expression, emerge as a potential therapeutic target for autoimmune diseases. While Tex impairs antitumor immunity, the reduced autoreactivity prevents the functioning of pathogenic CD8⁺T cells, contrasting with broad immunosuppression from … Read more

Curr Opin Immunol. 2025 Jul 2;95:102603. doi: 10.1016/j.coi.2025.102603. Online ahead of print. ABSTRACT PURPOSE OF THE REVIEW: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. RECENT FINDINGS: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as … Read more

Curr Opin Immunol. 2025 Jul 1:102598. doi: 10.1016/j.coi.2025.102598. Online ahead of print. NO ABSTRACT PMID:40603234 | DOI:10.1016/j.coi.2025.102598

Curr Opin Immunol. 2025 Jun 27;95:102597. doi: 10.1016/j.coi.2025.102597. Online ahead of print. ABSTRACT Although we can at present more effectively manage Behçet syndrome compared to several decades ago, we are not yet quite near a cure. Our main shortcoming is we have yet to decipher its cause(s) and disease mechanism(s). First, there are reasons to … Read more

Curr Opin Immunol. 2025 Jun 24;95:102596. doi: 10.1016/j.coi.2025.102596. Online ahead of print. ABSTRACT Autoimmune diseases represent a significant global health burden, characterized by aberrant immune responses leading to tissue damage and functional impairment. Despite advancements in immunosuppressive therapies, achieving sustained remission remains challenging, necessitating innovative therapeutic approaches. Chimeric antigen receptor (CAR) T cell therapy, a … Read more

Curr Opin Immunol. 2025 Jun 23;95:102591. doi: 10.1016/j.coi.2025.102591. Online ahead of print. ABSTRACT Pemphigus and bullous pemphigoid (BP) are both autoimmune bullous diseases (AIBD), but their clinical features and treatment strategies are different. Pemphigus is characterized by intraepidermal blisters mediated by antibodies against desmosomes, while BP is characterized by subepidermal blisters mediated by antibodies against … Read more

Curr Opin Immunol. 2025 Jun 23;95:102590. doi: 10.1016/j.coi.2025.102590. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disease whose main manifestation is scaly and erythematous plaques. The pathogenesis is complex, including genetic and environmental factors. In recent years, epigenetic modifications, which means changing in gene expression instead of altering the DNA sequence, have … Read more

Curr Opin Immunol. 2025 Jun 19;95:102587. doi: 10.1016/j.coi.2025.102587. Online ahead of print. ABSTRACT Psoriatic arthritis (PsA) is a systemic, immune-mediated disorder characterized by inflammation across peripheral and axial joints, entheses, skin, and nails. Given this heterogeneous manifestation, PsA presents unique challenges in clinical diagnosis and management. Conventional imaging, limited to localized, anatomical assessments, often fails … Read more

Curr Opin Immunol. 2025 Jun 19;95:102588. doi: 10.1016/j.coi.2025.102588. Online ahead of print. ABSTRACT Supporting the health and function of the central nervous system (CNS), the choroid plexus (CP) not only produces cerebrospinal fluid, but it also facilitates brain-immune interfacing, removes waste, and secretes proneuronal signals. Despite these key physiological contributions, a pathogenic role for the … Read more