Current Opinion in Immunology

Curr Opin Immunol. 2025 Jul 28;96:102617. doi: 10.1016/j.coi.2025.102617. Online ahead of print. ABSTRACT Blood transfusion is integral to modern medicine but carries significant immunological risks. This review outlines key immune-mediated complications, including acute hemolytic transfusion reactions from ABO incompatibility, and febrile nonhemolytic reactions caused by cytokines or antileukocyte antibodies. Other reactions include allergic responses, anaphylaxis … Read more

Curr Opin Immunol. 2025 Jul 28;96:102618. doi: 10.1016/j.coi.2025.102618. Online ahead of print. ABSTRACT As with all autoimmune diseases, antineutrophil cytoplasmic autoantibody (ANCA) vasculitis cannot be cured by a singular approach. This complexity arises because autoimmune conditions typically result from multiple hits to the immune system – including genetic predisposition, environmental exposures, infections, and perturbations in … Read more

Curr Opin Immunol. 2025 Jul 28;96:102616. doi: 10.1016/j.coi.2025.102616. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in elderly populations across developed countries. Complement system dysregulation has been implicated in AMD onset and evolution. Complement inhibition therapies have been authorized in the USA as the primary … Read more

Curr Opin Immunol. 2025 Jul 18;96:102612. doi: 10.1016/j.coi.2025.102612. Online ahead of print. ABSTRACT In order to stay circulating in the human population over many years, viruses need to adapt to the environment, mainly to the host’s immune response, allowing for reinfection despite preexisting immunity. These different viral strategies are clearly important for guiding vaccine design. … Read more

Curr Opin Immunol. 2025 Jul 18;96:102615. doi: 10.1016/j.coi.2025.102615. Online ahead of print. ABSTRACT Langerhans cells (LCs), the professional antigen-presenting cells in the epidermis, serve as the first line of defense in the skin’s immune system. With advancements in detection technologies and the development of diverse animal models, LCs have been shown to exhibit heterogeneous origins, … Read more

Curr Opin Immunol. 2025 Jul 17;96:102613. doi: 10.1016/j.coi.2025.102613. Online ahead of print. ABSTRACT Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease affecting the intra- and extra-hepatic bile ducts, leading to progressive inflammation and fibrosis. Its pathogenesis is complex and involves genetic predisposition, environmental triggers, and their interaction through the gut-liver axis, mediated … Read more

Curr Opin Immunol. 2025 Jul 18;96:102608. doi: 10.1016/j.coi.2025.102608. Online ahead of print. ABSTRACT In systemic lupus erythematosus (SLE), chronic autoimmunity and sustained inflammation can lead to the development of neuropsychiatric lupus (NPSLE) in up to 80% of patients. Elevated interferon-alpha (IFNα) is detected in serum and cerebrospinal fluid, making it a major focus in studies … Read more

Curr Opin Immunol. 2025 Jul 16;96:102607. doi: 10.1016/j.coi.2025.102607. Online ahead of print. ABSTRACT Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of anti-HLA-I alloantibodies in patient circulation, which can lead … Read more

Curr Opin Immunol. 2025 Jul 16;96:102611. doi: 10.1016/j.coi.2025.102611. Online ahead of print. ABSTRACT Axial spondyloarthritis (axSpA) manifests with inflammatory back pain and is diagnosed predominantly in subjects carrying the human leucocyte antigen (HLA)-B27 allele. While not diagnostic for the disease or a predictive biomarker in the general population, there is convincing data on the pathogenic … Read more

Curr Opin Immunol. 2025 Jul 16;96:102614. doi: 10.1016/j.coi.2025.102614. Online ahead of print. ABSTRACT Psoriasis is increasingly recognized as a metabolically regulated inflammatory skin disease. Aberrant glycolysis, oxidative phosphorylation, lipid metabolism, and amino acid metabolism reshape T cell, dendritic cell, macrophage, and neutrophil responses, driving chronic inflammation. Keratinocyte-derived metabolites further amplify immune dysfunction, establishing a reciprocal … Read more