Current Opinion in Immunology

Curr Opin Immunol. 2025 Jul 16;96:102607. doi: 10.1016/j.coi.2025.102607. Online ahead of print. ABSTRACT Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of anti-HLA-I alloantibodies in patient circulation, which can lead … Read more

Curr Opin Immunol. 2025 Jul 16;96:102611. doi: 10.1016/j.coi.2025.102611. Online ahead of print. ABSTRACT Axial spondyloarthritis (axSpA) manifests with inflammatory back pain and is diagnosed predominantly in subjects carrying the human leucocyte antigen (HLA)-B27 allele. While not diagnostic for the disease or a predictive biomarker in the general population, there is convincing data on the pathogenic … Read more

Curr Opin Immunol. 2025 Jul 16;96:102614. doi: 10.1016/j.coi.2025.102614. Online ahead of print. ABSTRACT Psoriasis is increasingly recognized as a metabolically regulated inflammatory skin disease. Aberrant glycolysis, oxidative phosphorylation, lipid metabolism, and amino acid metabolism reshape T cell, dendritic cell, macrophage, and neutrophil responses, driving chronic inflammation. Keratinocyte-derived metabolites further amplify immune dysfunction, establishing a reciprocal … Read more

Curr Opin Immunol. 2025 Jul 14;96:102609. doi: 10.1016/j.coi.2025.102609. Online ahead of print. ABSTRACT Autoimmune hepatitis (AIH) is an organ-specific autoimmune disorder mainly affecting females and characterized by seropositivity for autoantibodies, hypergammaglobulinemia, and histological evidence of interface hepatitis. Liver damage in AIH is perpetrated by multiple immune cell subsets, including B, T lymphocytes, and macrophages. Dysfunction … Read more

Curr Opin Immunol. 2025 Jul 10;96:102606. doi: 10.1016/j.coi.2025.102606. Online ahead of print. ABSTRACT Biological therapy has revolutionized the treatment landscape of complex and chronic conditions, including autoimmune diseases and cancer. However, their high costs have significantly limited patient access, particularly in low- and middle-income regions, such as Latin America and the Caribbean (LAC). As cost-effective … Read more

Curr Opin Immunol. 2025 Jul 7;95:102601. doi: 10.1016/j.coi.2025.102601. Online ahead of print. ABSTRACT Psoriatic disease encompasses psoriasis and psoriatic arthritis. It is a chronic, progressive condition and leads to irreversible joint destruction. Conventional treatments used are disease-modifying antirheumatic drugs and biologics. Janus kinase (JAK) signal transducers and activators of transcription (STAT) cell signaling protein inhibitors … Read more

Curr Opin Immunol. 2025 Jul 7;95:102602. doi: 10.1016/j.coi.2025.102602. Online ahead of print. ABSTRACT Biologic therapies have significantly improved the management of immune-mediated conditions like psoriatic disease, enhancing the quality of life of patients. However, monotherapy is often insufficient, especially in cases of relapse, concomitant psoriatic arthritis, and involvement of difficult-to-treat areas: the scalp, palmoplantar areas, … Read more

Curr Opin Immunol. 2025 Jul 4;95:102599. doi: 10.1016/j.coi.2025.102599. Online ahead of print. ABSTRACT Autoinflammatory diseases are a group of immune dysregulation disorders, with genetic mutations identified in approximately 50% of patients. However, patients with known pathogenic mutations may display a broad range of phenotypic diversity. Epigenetic modifications play a crucial role in regulating immune-mediated diseases, … Read more

Curr Opin Immunol. 2025 Jul 3;95:102604. doi: 10.1016/j.coi.2025.102604. Online ahead of print. ABSTRACT Autoimmune hemolytic anemia (AIHA) is a rare disorder caused by loss of tolerance to red blood cell (RBC) antigens, leading to their destruction by autoantibodies. AIHA can occur as a primary condition or secondary to infections, malignancies, or immune-modulating therapies, such as … Read more

Curr Opin Immunol. 2025 Jul 3;95:102605. doi: 10.1016/j.coi.2025.102605. Online ahead of print. ABSTRACT PURPOSE OF THE REVIEW: Platelet and red blood cell (RBC) transfusions, whether used as prophylactic measures or therapeutic interventions, are critical for saving lives. However, the composition of platelet and RBC concentrates used for transfusion may contribute to adverse reactions following transfusion. … Read more