Curr Opin Immunol. 2025 Nov 6;98:102689. doi: 10.1016/j.coi.2025.102689. Online ahead of print. ABSTRACT Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are leading causes of transfusion-related morbidity and mortality. Despite distinct diagnostic criteria, both syndromes present similarly with respiratory distress and pulmonary edema. In recent research, they increasingly appear to share pathophysiological and … Read more

Curr Opin Immunol. 2025 Nov 5;98:102688. doi: 10.1016/j.coi.2025.102688. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disease marked by abnormal keratinocyte growth, immune dysfunction, and a weakened skin barrier. Affecting 2-3% of the global population, it lowers quality of life and is linked to systemic conditions. Though treatments have improved, many patients … Read more

Curr Opin Immunol. 2025 Oct 31;98:102683. doi: 10.1016/j.coi.2025.102683. Online ahead of print. ABSTRACT The production of indole-3-acetic acid (IAA, auxin) is universal in microbes and plants, and contributes to human wellness, acting as an anticancer and anti-inflammatory agent. This review highlights the ubiquity of IAA production by microbes and plants, as well as its role … Read more

Curr Opin Immunol. 2025 Oct 30;98:102685. doi: 10.1016/j.coi.2025.102685. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) are a rare subset of T cells that are potent regulators of the immune system. As a result, the use of Tregs to prevent undesired immune activation and to re-establish immune balance is an attractive cellular therapy approach. … Read more

Curr Opin Immunol. 2025 Oct 29;98:102686. doi: 10.1016/j.coi.2025.102686. Online ahead of print. ABSTRACT Complement inhibition has revolutionized the management of hemolytic diseases by targeting the underlying drivers of red blood cell destruction in disorders such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and cold agglutinin disease. Recent advances have expanded the therapeutic landscape beyond … Read more

Curr Opin Immunol. 2025 Oct 29;98:102687. doi: 10.1016/j.coi.2025.102687. Online ahead of print. ABSTRACT Excessive complement activation represents a major pathogenic mechanism for a range of serious human diseases. Complement-inhibitory therapeutics have been approved for a number of rare and ultra-rare conditions, with several others in clinical development. The vast majority of these complement-targeted drugs act … Read more

Curr Opin Immunol. 2025 Oct 27;97:102681. doi: 10.1016/j.coi.2025.102681. Online ahead of print. ABSTRACT Infectious agents are potential triggers for autoimmune diseases (ADs) in susceptible individuals, with infection being a key factor in initiating autoimmunity. Epidemiological and experimental evidence suggests molecular mimicry as a plausible mechanism for breaking peripheral tolerance, leading to clinical disease. However, molecular … Read more

Curr Opin Immunol. 2025 Oct 23;97:102682. doi: 10.1016/j.coi.2025.102682. Online ahead of print. ABSTRACT Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protective immune memory responses rarely develop. Malaria induces … Read more

Curr Opin Immunol. 2025 Oct 17;97:102680. doi: 10.1016/j.coi.2025.102680. Online ahead of print. ABSTRACT While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often under-scrutinized compared to T cell pathways. PMN … Read more

Curr Opin Immunol. 2025 Oct 14;97:102678. doi: 10.1016/j.coi.2025.102678. Online ahead of print. ABSTRACT Neurotropic viruses represent a public health challenge due to their ability to cause severe neurological conditions, including meningitis, encephalitis, and paralysis. Although many studies have investigated the immune responses to viral infections in the brain and other nervous system targets, most have … Read more