Current Opinion in Immunology

Curr Opin Immunol. 2026 Mar 28;100:102761. doi: 10.1016/j.coi.2026.102761. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is increasingly understood as a systemic disorder with early manifestations outside the central nervous system. Converging clinical, metabolic, and immunological observations highlight overlaps between PD and primary biliary cholangitis (PBC), a prototypic autoimmune cholestatic liver disease. A shared hallmark … Read more

Curr Opin Immunol. 2026 Mar 26;100:102768. doi: 10.1016/j.coi.2026.102768. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disorder in which antiphospholipid antibodies cause vascular thrombosis and obstetric morbidity. Growing evidence indicates that neutrophils and monocytes are key effector cells bridging inflammation and coagulation in APS. Neutrophils display heightened activation, enhanced glycolysis, and … Read more

Curr Opin Immunol. 2026 Mar 23;100:102760. doi: 10.1016/j.coi.2026.102760. Online ahead of print. ABSTRACT This review comprehensively explores the emerging roles of gut microbiota in the pathogenesis and therapeutic implications of rheumatoid arthritis (RA). Clinically, RA is a challenging autoimmune disease due to unclear pathology and limitations of conventional therapies. Recent studies highlight that gut dysbiosis … Read more

Curr Opin Immunol. 2026 Mar 16;100:102755. doi: 10.1016/j.coi.2026.102755. Online ahead of print. ABSTRACT Mpox is a smallpox-like disease caused by the monkeypox virus. In 2022, a global outbreak of mpox resulted in more than 113 000 cases. Just a year later, a different strain of mpox caused the largest ever outbreak in Africa, with over … Read more

Curr Opin Immunol. 2026 Mar 16;100:102758. doi: 10.1016/j.coi.2026.102758. Online ahead of print. ABSTRACT The traditional randomized controlled trial (RCT), a most valuable tool of evidence-based medicine, is rapidly evolving into new forms. The main reason behind this evolution is the basic explanatory nature of RCT and the related need for real-world data to help with … Read more

Curr Opin Immunol. 2026 Mar 16;100:102754. doi: 10.1016/j.coi.2026.102754. Online ahead of print. ABSTRACT Non-communicable diseases, including metabolic, inflammatory, and malignant disorders, now dominate global morbidity and mortality. These chronic, lifestyle-associated diseases expose the limits of strategies focused on suppressing late-stage inflammation. We argue that immune dyshomeostasis – rather than overt inflammation – represents the more … Read more

Curr Opin Immunol. 2026 Mar 14;100:102757. doi: 10.1016/j.coi.2026.102757. Online ahead of print. ABSTRACT Kv1.3 is a voltage-gated potassium channel expressed on immune cells. It functions in coordination with calcium channels to maintain cellular homeostasis. Several studies support important roles for Kv1.3 in microglia-driven neuroinflammation and T cell-mediated autoimmunity. Based on recent evidence, Kv1.3 may regulate … Read more

Curr Opin Immunol. 2026 Mar 13;100:102756. doi: 10.1016/j.coi.2026.102756. Online ahead of print. ABSTRACT We are at the dawn of a new era in the biomedical prevention of childhood malaria. The successful development and ongoing rollout of the first malaria vaccines, RTS,S/AS01E and R21/Matrix-M, have injected much-needed optimism into the malaria prevention field. Additional new vaccines … Read more

Curr Opin Immunol. 2026 Mar 12;100:102752. doi: 10.1016/j.coi.2026.102752. Online ahead of print. ABSTRACT P2 purinergic receptors are activated by extracellular adenosine triphosphate and other nucleotides released during inflammatory processes, cellular stress responses, and amplification by NETosis, thereby serving as pivotal mediators of both innate and adaptive immunity. In patients with active systemic lupus erythematosus (SLE), … Read more

Curr Opin Immunol. 2026 Mar 10;100:102749. doi: 10.1016/j.coi.2026.102749. Online ahead of print. ABSTRACT Graft versus host disease (GVHD) is one of the major complications of allogeneic hematopoietic cell transplantation (allo-HCT), contributing significantly to post-transplant morbidity and mortality. Anti-thymocyte globulin (ATG) is a widely used GVHD prophylaxis in combination with a calcineurin inhibitor and an antimetabolite. … Read more