Curr Opin Immunol. 2026 Apr 7;100:102771. doi: 10.1016/j.coi.2026.102771. Online ahead of print. ABSTRACT Identified in the 1990s as the primary target of antiphospholipid antibodies (aPL) in antiphospholipid syndrome (APS), β2-glycoprotein I (β2GPI) remains a central focus in hematology and immunology. Anti-β2GPI antibodies are important not only for diagnosing APS but also play a key role … Read more
Curr Opin Immunol. 2026 Apr 2;100:102769. doi: 10.1016/j.coi.2026.102769. Online ahead of print. ABSTRACT Although immunometabolism has emerged as a central area of research in infectious diseases, only a few studies have focused on Plasmodium vivax infection. Here, we discuss the results obtained in our laboratory and elsewhere that show a metabolic-mitochondria shift in highly activated … Read more
Curr Opin Immunol. 2026 Mar 30;100:102759. doi: 10.1016/j.coi.2026.102759. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is increasingly recognised as a multifactorial and heterogeneous condition rather than a single uniform disorder, supported by advances in molecular biology, genetics and pathology. This review provides a perspective on the shifting concept of PD from an idiopathic, strictly … Read more
Curr Opin Immunol. 2026 Mar 28;100:102761. doi: 10.1016/j.coi.2026.102761. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is increasingly understood as a systemic disorder with early manifestations outside the central nervous system. Converging clinical, metabolic, and immunological observations highlight overlaps between PD and primary biliary cholangitis (PBC), a prototypic autoimmune cholestatic liver disease. A shared hallmark … Read more
Curr Opin Immunol. 2026 Mar 26;100:102768. doi: 10.1016/j.coi.2026.102768. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disorder in which antiphospholipid antibodies cause vascular thrombosis and obstetric morbidity. Growing evidence indicates that neutrophils and monocytes are key effector cells bridging inflammation and coagulation in APS. Neutrophils display heightened activation, enhanced glycolysis, and … Read more
Curr Opin Immunol. 2026 Mar 23;100:102760. doi: 10.1016/j.coi.2026.102760. Online ahead of print. ABSTRACT This review comprehensively explores the emerging roles of gut microbiota in the pathogenesis and therapeutic implications of rheumatoid arthritis (RA). Clinically, RA is a challenging autoimmune disease due to unclear pathology and limitations of conventional therapies. Recent studies highlight that gut dysbiosis … Read more
Curr Opin Immunol. 2026 Mar 16;100:102755. doi: 10.1016/j.coi.2026.102755. Online ahead of print. ABSTRACT Mpox is a smallpox-like disease caused by the monkeypox virus. In 2022, a global outbreak of mpox resulted in more than 113 000 cases. Just a year later, a different strain of mpox caused the largest ever outbreak in Africa, with over … Read more
Curr Opin Immunol. 2026 Mar 16;100:102758. doi: 10.1016/j.coi.2026.102758. Online ahead of print. ABSTRACT The traditional randomized controlled trial (RCT), a most valuable tool of evidence-based medicine, is rapidly evolving into new forms. The main reason behind this evolution is the basic explanatory nature of RCT and the related need for real-world data to help with … Read more
Curr Opin Immunol. 2026 Mar 16;100:102754. doi: 10.1016/j.coi.2026.102754. Online ahead of print. ABSTRACT Non-communicable diseases, including metabolic, inflammatory, and malignant disorders, now dominate global morbidity and mortality. These chronic, lifestyle-associated diseases expose the limits of strategies focused on suppressing late-stage inflammation. We argue that immune dyshomeostasis – rather than overt inflammation – represents the more … Read more
Curr Opin Immunol. 2026 Mar 14;100:102757. doi: 10.1016/j.coi.2026.102757. Online ahead of print. ABSTRACT Kv1.3 is a voltage-gated potassium channel expressed on immune cells. It functions in coordination with calcium channels to maintain cellular homeostasis. Several studies support important roles for Kv1.3 in microglia-driven neuroinflammation and T cell-mediated autoimmunity. Based on recent evidence, Kv1.3 may regulate … Read more
