Curr Opin Immunol. 2026 Mar 10;100:102753. doi: 10.1016/j.coi.2026.102753. Online ahead of print. ABSTRACT The complexity and heterogeneity of autoimmune diseases are only partially captured by current analytic tools, even when deep learning techniques are employed to intercept patterns beyond existing dogma. Synthetic data offer a newer paradigm through machine-generated reconstructions of real-world data that faithfully … Read more
Curr Opin Immunol. 2026 Mar 10;100:102748. doi: 10.1016/j.coi.2026.102748. Online ahead of print. ABSTRACT The term autoimmune disease refers to autoantibody-dependent pathophysiological conditions, in which characterising the autoantibodies is essential, as is studying their target(s), the (auto)antigen(s), which represent the other side of the coin. In this review, we aimed to go further inside the ultimate … Read more
Curr Opin Immunol. 2026 Mar 3;100:102750. doi: 10.1016/j.coi.2026.102750. Online ahead of print. ABSTRACT The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, KV1.3 has been postulated to exert additional functions … Read more
Curr Opin Immunol. 2026 Mar 3;100:102751. doi: 10.1016/j.coi.2026.102751. Online ahead of print. ABSTRACT Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates neuroinflammation and contributes to a range of central nervous system pathologies. Our recent work … Read more
Curr Opin Immunol. 2026 Mar 3;100:102743. doi: 10.1016/j.coi.2026.102743. Online ahead of print. ABSTRACT Despite major advances in understanding Sjögren’s disease (SjD), no approved disease-modifying therapies have been approved. Management remains largely symptomatic with the use of off-label immunomodulators for systemic features. This gap highlights the substantial unmet need for targeted treatment. Encouragingly, the therapeutic landscape … Read more
Curr Opin Immunol. 2026 Mar 3;100:102747. doi: 10.1016/j.coi.2026.102747. Online ahead of print. ABSTRACT Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this … Read more
Curr Opin Immunol. 2026 Mar 2;100:102745. doi: 10.1016/j.coi.2026.102745. Online ahead of print. ABSTRACT Endothelial dysfunction (ED) is a hallmark of antiphospholipid syndrome (APS) driven by chronic antiphospholipid antibody (aPL) exposure. Beyond acute thrombotic events, ED contributes to atherosclerosis, vascular remodelling, stenosis and multi-organ manifestations, positioning the endothelium as a putative target for disease monitoring and … Read more
Curr Opin Immunol. 2026 Feb 27;99:102744. doi: 10.1016/j.coi.2026.102744. Online ahead of print. ABSTRACT The reemergence of the mpox virus (MPXV) as a global health threat, with >100 000 cases reported across 115 countries since the WHO’s 2022 alert, has intensified research into its pathophysiology. MPXV exists in two main clades with distinct geographic and clinical … Read more
Curr Opin Immunol. 2026 Feb 27;99:102742. doi: 10.1016/j.coi.2026.102742. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a highly heterogeneous chronic systemic inflammatory disease. Approximately 30-40% of patients exhibit an inadequate response to currently available biologic agents and Janus kinase inhibitors. In recent years, rapid advances in multi-omics technologies, including genomics, temporal transcriptomics, proteomics, metabolomics, … Read more
Curr Opin Immunol. 2026 Feb 27;99:102746. doi: 10.1016/j.coi.2026.102746. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Psoriatic arthritis (PsA) is a multidomain inflammatory disease where no instrument captures the full spectrum of activity or its impact on patients’ lives. Accurate outcome measurement is essential for research and personalized care. This review summarizes advances in PsA … Read more
