Far from homogeneous, neutrophils acquire remarkable diversity, particularly in the context of cancer. Ng, Cerezo-Wallis, Ng, and Hidalgo discuss the origin and mechanisms underlying the adaptation of neutrophils to cancer. They highlight intrinsic and…
Mitochondria play critical roles in intrinsic apoptosis and NLRP3 inflammasome activation, but how these processes are interconnected remains unclear. In this issue of Immunity, Saller et al. unveiled the complexity of NLRP3 activators, highlighting mi…
Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose …
Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and systemic immune cells. Iadecola and Anrather discuss the n…
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associ…
Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al. uncover an anxiolytic function of intestinal IL-22 path…
The mechanisms underpinning susceptibility to influenza virus infection, resulting in life-threatening disease, are not well understood. In this issue of Immunity, Chakraborty et al. demonstrate that sialylated IgG suppresses NF-κB-driven inflammatory …
ABCC1 mediates the export of cGAMP, but the underlying molecular mechanism of cGAMP recognition and export is not clear. Here, Shinde et al. show that human ABCC1 forms a dimer in vitro and in vivo. Cryo-EM structures of ligand-free and cGAMP-bound ABC…
Interferon γ secretion by activated T cells alters the immunopeptidome landscape of cancer cells, enriching for W>F substitutant epitopes. Champagne et al. demonstrate that these induced neoepitopes are widespread, shared between cancer types, and are …
There are many dimensions to scientific life. We asked investigators about the impact of service to the scientific community and beyond and how service has shaped their experience, perspective, and research path.
