The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes. We discuss current uses of the term extrafollicula…
While microglial activation is a hallmark in neurodegeneration, the specific role of microglia in disease-related cortical excitability remains unknown. Xie et al. reveal that rod-shaped microglia form in response to early cortical hyperactivity in a m…
Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive monocytes to tumor-draining lymph nodes. By co-targeting this recruitment,…
Integrin CD103 mediates memory T cell tissue residency by binding E-cadherin-expressing epithelial cells, but why CD103 is also expressed on circulating naive CD8+ T cells has been unclear. Li et al. report that CD103 facilitates the interaction of nai…
Chronic rhinosinusitis (CRS) is driven by poorly understood immune-epithelial crosstalk. Liao et al. present a single-cell and spatial transcriptomic atlas of CRS, revealing how immune and epithelial cells interact to drive tissue remodeling and inflam…
The functional state of tumor-infiltrating lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that mitochondrial ROS accumulation induces oxidative damage at telomeres, which is suf…
Dr. Zelig Eshhar, a professor of immunology at the Weizmann Institute of Science and head of immunology research at the Tel Aviv Sourasky Medical Center, passed away on July 3, 2025, at the age of 84. Zelig was best known as the pioneer of chimeric ant…
Clinical and therapeutic innovation relies on our understanding of the human immune system. Here, investigators discuss current and developing methodologies to study human immunity, and the importance of thoughtful experimental design and sample collec…
In a recent issue of Nature, Adrover et al. report a neutrophil subset that induces pleomorphic tumor necrosis through NET-mediated vascular occlusion. This process drives epithelial-to-mesenchymal transition and metastasis of perinecrotic cancer cells…
Wang et al. demonstrate that gut rather than skin microbiota promote skin inflammation in a spontaneous psoriasis mouse model by fueling the production of the metabolite indoxyl sulfate (I3S). I3S amplifies Th17-mediated skin inflammation via AHR-depen…
