CAR-T cells form disorganized immunological synapses. Xu et al. find that incorporation of the CD3ε module into CAR induces liquid-liquid phase separation, promoting the formation of mature immunological synapse with integrated antigen and costimulator…
How dendritic cells (DCs) regulate human tissue immunity remains unclear. MacDonald, Elmesmari, Somma, Frew, et al. investigate the role of synovial tissue (ST) myeloid DCs in health and active and remission stages of rheumatoid arthritis. Using a comb…
Ogishi, Kitaoka, et al. examine humans deficient in PD-1 and PD-L1 as well as associated mouse models and find that PD-1 and PD-L1 promote B cell memory and antibody responses through both T cell-dependent and B cell-intrinsic mechanisms. Their finding…
Overexpression of transposable elements is a common feature of cancer. Sun, You, et al. show that, in pancreatic ductal adenocarcinoma, tumor cells adapt through different mechanisms to mitigate a specific group of dsRNA-producing repeats in a TP53-dep…
Through an in vivo Rainbow-CRISPR screen, Wang et al. systematically assess the roles of each of 35 nuclear receptors (NRs) across the immune system, revealing focal, cell-specific involvements as well as noncanonical functions. In cavity macrophages, …
Mitochondria control metabolism, cell death, and innate immunity, yet their reciprocal mechanistic connections are elusive, as is the conserved physiological function of the NLRP3 inflammasome. Saller et al. reveal that inhibition of mitochondrial ATP …
MHC class I interactions with different immune receptors can mediate either activating or inhibitory functions. Tsao, Anderson, Finn, et al. show that loss of ERAP, the aminopeptidase that trims peptides for presentation on MHC class I, enhances immune…
Several recent studies have demonstrated that B cell targeting chimeric antigen receptor (CAR) T cells offer a viable treatment option for patients with autoantibody-mediated autoimmune diseases. In this report, we summarize recent findings and key dev…
Anti-inflammatory sialylated IgG is enriched in younger people and in mild influenza patients. Chakraborty, Yik-Ling Cheng, Edwards, Gonzalez, et al. define a mechanism by which sialylated IgG induces expression of the transcription factor REST in alve…
Resistance to tyrosine kinase inhibitors (TKIs) in lung cancer brain metastasis (LCBM) remains a clinical challenge. Recently in Cancer Cell, Fu et al. reveal how TKIs reshape the immune microenvironment of LCBM and propose CTLA4 blockade as a promisin…
