Aicardi-Goutières syndrome is an autoinflammatory brain disease associated with increased interferon-α production, but the primary source and mediators of neurotoxicity are poorly described. Viengkhou et al. show that neurotoxic interferon-α originates…
Infants are highly vulnerable to RSV infection. However, the contribution of the evolving RSV-specific humoral immune response to RSV immunity remains incompletely understood. Nziza et al. profiled pediatric humoral immunity to RSV fusion and attachmen…
Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by histocompatibility antigen disparities between donor and recipient. Yeh et al. found that a subset of donor CD…
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al. elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of c…
The mechanisms that make and break CD8+ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8+ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibi…
AI is rapidly becoming part of many aspects of daily life, with an impact that reaches all fields of research. We asked investigators to share their thoughts on how AI is changing immunology research, what is necessary to move forward, the potential an…
Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cell…
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PG…
Long COVID (LC) has become a major public health concern, necessitating multi-pronged research efforts to understand the pathophysiologic mechanisms of this condition and aid in patient diagnosis and treatment. In this perspective, Hamlin and Blish rev…
Phagocytic microglia such as proliferative region-associated microglia and disease-associated microglia appear in the brain transiently during development and across various brain pathologies, but their function and degree of plasticity remain unclear….
