In contrast to other immune cell lineages, little is known about how eosinophils develop, expand, and mature in health and disease. Using single-cell RNA sequencing, high-dimension flow cytometric screening, and IL-5Rα reporter mice, Jorssen, Van Hulst…
Steady-state antigen recognition triggers tolerant CD8+ T cell states that restrain autoimmunity and limit anti-cancer immunity. The relationship between tolerant states and other differentiation states remains unclear. Van Der Byl et al. demonstrate t…
How immune and epithelial cells simultaneously fuel their dysfunction in chronic skin diseases is unclear. Subudhi and Konieczny et al. find that IL-17-induced epithelial HIF1α activates glycolysis, which potentiates the γδ T17 response via lactate. Th…
Obesity induces ILC2 dysfunction in adipose tissue and insulin resistance by undetermined mechanisms. Here, Sun et al. show that liver kinase B1 (LKB1) signaling protects ILC2s from mitophagy by suppressing PD-1 expression. Moreover, PD-1 blockade rest…
Cellular and molecular mechanisms leading to SLE are unclear. Li et al. show that SLE CD4+ T cells downregulate CBLs and ablation of CBLs in mouse T cells causes hyper Tfh cell responses and SLE. CBLs restrain Tfh cell responses by ubiquitinating ICOS,…
Pancreatic islet β cells are highly sensitive to autoinflammatory insults, in part due to their highly oxidative microenvironment. Srivastava et al. report that CXCL16 on resident islet macrophages scavenges OxLDL in pancreatic islets. This process, wh…
Ferroptosis is a distinct form of regulated cell death highlighted by the contributions of lipid peroxidation and iron. In this review, Zou and colleagues summarize and interpret the literature on the mechanism and role of ferroptosis in the context of…
Beyond their hemostatic roles, platelets are critical for host responses against pathogens. Dysregulated activation of these multitalented cells may also contribute to immunopathology with ensuing microvascular clotting, excessive innate immune respons…
Astrocytes respond to all forms of central nervous system maladies. In a recent issue of Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic memory, which strengthens responses to subsequent stimuli and exacerbates …
The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating pro…
