Journal of Leukocyte Biology

J Leukoc Biol. 2024 Nov 28:qiae252. doi: 10.1093/jleuko/qiae252. Online ahead of print. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, remains endemic worldwide. Circulating levels of the chemokine CXCL10 are strongly positively associated with poor outcome; however, its precise role in SARS-CoV-2 pathogenesis and its … Read more

J Leukoc Biol. 2024 Nov 22:qiae249. doi: 10.1093/jleuko/qiae249. Online ahead of print. ABSTRACT The pre-T cell receptor (TCR) and TCR complexes are frequently expressed in T-cell acute lymphoblastic leukemia (T-ALL), an aggressive T cell precursor malignancy. Although mutations in TCR components are infrequent in T-ALL, earlier research indicated that transgenic αβ TCR expression in mouse … Read more

J Leukoc Biol. 2024 Nov 20:qiae248. doi: 10.1093/jleuko/qiae248. Online ahead of print. ABSTRACT Brain metastases (BrM) originating from lung and breast cancer can recruit and activate neutrophils to acquire a tumor-promoting phenotype. It is currently unclear if this phenomenon also occurs in BrM arising from other primary sites. Here, we investigated the effect of tumor … Read more

J Leukoc Biol. 2024 Nov 14:qiae246. doi: 10.1093/jleuko/qiae246. Online ahead of print. ABSTRACT Tuberculosis (TB) is one of the leading causes of death worldwide and a major public health problem. Immune evasion mechanisms and antibiotic resistance highlight the need to better understand this disease and explore alternative treatment approaches. Mycobacterial infection modulates the macrophage response … Read more

J Leukoc Biol. 2024 Nov 12:qiae239. doi: 10.1093/jleuko/qiae239. Online ahead of print. ABSTRACT Oral mucosal colonization by C. albicans (Ca) is benign in healthy people but progresses to deeper infection known as oropharyngeal candidiasis (OPC) that may become disseminated when combined with immunosuppression. Cortisone use and neutropenia are risk factors for invasive mucosal fungal infections, … Read more

J Leukoc Biol. 2024 Nov 8:qiae220. doi: 10.1093/jleuko/qiae220. Online ahead of print. ABSTRACT Neutrophils are traditionally viewed as uncomplicated exterminators that arrive quickly at sites of infection, kill pathogens, and then expire. However, recent studies employing modern transcriptomics coupled with novel imaging modalities have discovered that neutrophils exhibit significant heterogeneity within organs and have complex … Read more

J Leukoc Biol. 2024 Nov 8:qiae213. doi: 10.1093/jleuko/qiae213. Online ahead of print. NO ABSTRACT PMID:39513711 | DOI:10.1093/jleuko/qiae213

J Leukoc Biol. 2024 Nov 7:qiae210. doi: 10.1093/jleuko/qiae210. Online ahead of print. ABSTRACT Ectopic lipid accumulation in macrophages is responsible for the formation of macrophage foam cells (MFCs) which are involved in the crosstalk with the perivascular adipose tissue (PVAT) of the vascular wall that plays a pivotal role in the progression of atherosclerosis. However, … Read more

J Leukoc Biol. 2024 Nov 13:qiae238. doi: 10.1093/jleuko/qiae238. Online ahead of print. NO ABSTRACT PMID:39535245 | DOI:10.1093/jleuko/qiae238

J Leukoc Biol. 2024 Nov 12:qiae240. doi: 10.1093/jleuko/qiae240. Online ahead of print. ABSTRACT Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous … Read more