Journal of Leukocyte Biology

J Leukoc Biol. 2025 Feb 13;117(2):qiae247. doi: 10.1093/jleuko/qiae247. ABSTRACT Sjogren’s syndrome (SS) is an autoimmune epithelitis characterized by focal lymphocytic infiltration against self-antigens leading to progressive glandular dysfunction, which can develop to multisystem manifestation. The classification criteria for SS emphasizes glandular lymphocyte infiltrates and anti-SSA/SSB seropositivity, which is usually manifested in advanced patients. Therapeutically, apart … Read more

J Leukoc Biol. 2025 Feb 13;117(2):qiae250. doi: 10.1093/jleuko/qiae250. ABSTRACT Quantification of neutrophil counts is the most relevant assessment of cellular immunity in clinical practice. Patients with neutropenia are considered at risk and are categorized according to its severity. The incidence of febrile neutropenia varies, but patients with acute myeloid leukemia are traditionally considered at high … Read more

J Leukoc Biol. 2025 Feb 13:qiaf018. doi: 10.1093/jleuko/qiaf018. Online ahead of print. ABSTRACT Highly active antiretroviral drug (HAART) is the standard treatment for HIV-1 infection to suppress the viral load. However, this treatment does not completely eradicate the virus; it simply decreases the viral load to undetectable levels. The development of a novel therapy to … Read more

J Leukoc Biol. 2025 Feb 13:qiaf019. doi: 10.1093/jleuko/qiaf019. Online ahead of print. ABSTRACT Receptors for the Fc portion of IgG antibodies (FcγR) on human neutrophils constitute an important mechanism for recognition of opsonized microorganisms and for cell activation. Human neutrophils express two FcγR: FcγRIIa and FcγRIIIb. Previously, it has been reported that activation of each … Read more

J Leukoc Biol. 2025 Feb 12:qiaf017. doi: 10.1093/jleuko/qiaf017. Online ahead of print. ABSTRACT Neutrophils, the most abundant leukocytes in human blood, have long been recognized as critical first responders in the innate immune system’s defense against pathogens. Some of the more notable innate anti-microbial properties of neutrophils include generation of superoxide free radicals like myeloperoxidase … Read more

J Leukoc Biol. 2025 Feb 12:qiaf015. doi: 10.1093/jleuko/qiaf015. Online ahead of print. ABSTRACT The immune response goes haywire during sepsis. The aim of this study was to explore the role of CD57+γδ T cells in the immune pathogenesis of sepsis. We characterized the transcriptomic profile of peripheral γδ T cells obtained from patients with sepsis … Read more

J Leukoc Biol. 2025 Feb 4:qiaf013. doi: 10.1093/jleuko/qiaf013. Online ahead of print. ABSTRACT Atypical chemokine receptors (ACKRs) are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered as a scavenger of multiple inflammatory chemokines exclusively from the CC family. Recently, we demonstrated the ability of ACKR2 to scavenge the … Read more

J Leukoc Biol. 2025 Feb 4:qiaf011. doi: 10.1093/jleuko/qiaf011. Online ahead of print. ABSTRACT Natural Killer (NK) cells are crucial in recognizing and eliminating tumor cells, making them pivotal in antitumor responses. Adenosine, the product of ATP hydrolysis mediated by CD39 and CD73 ectonucleotidases, has been reported to reduce the proliferation and maturation of NK cells. … Read more

J Leukoc Biol. 2025 Feb 3:qiaf010. doi: 10.1093/jleuko/qiaf010. Online ahead of print. ABSTRACT Extracellular ATP released from dying cells, including tumor cells, is a key mediator of inflammation and tolerance by binding to purinergic receptors on dendritic cells, resulting in inflammasome activation (via P2X7R), dendritic cell maturation (via P2Y11R), and Indoleamine-2,3-dioxygenase 1 upregulation. However, the … Read more

J Leukoc Biol. 2025 Jan 30:qiaf012. doi: 10.1093/jleuko/qiaf012. Online ahead of print. ABSTRACT Regulated sequential exocytosis of neutrophil granules is essential in orchestrating the innate immune response, while uncontrolled secretion causes inflammation. We developed and characterized Nexinhib20, a small-molecule inhibitor that targets azurophilic granule exocytosis in neutrophils by blocking the interaction between the small GTPase … Read more