Nature Reviews Immunology, Published online: 22 September 2025; doi:10.1038/s41577-025-01228-4Many patients with cancer who could potentially benefit from treatment with chimeric antigen receptor (CAR)-T cells do not have access to thi…
Nature Reviews Immunology, Published online: 22 September 2025; doi:10.1038/s41577-025-01222-wNeoadjuvant (chemo)immunotherapy has become a new standard-of-care option for patients with cancer. This Perspective discusses the lessons le…
Nature Reviews Immunology, Published online: 12 September 2025; doi:10.1038/s41577-025-01215-9Despite the advances in hepatitis C treatment, a prophylactic vaccine is still not available and will be needed to control and eliminate hepa…
Nature Reviews Immunology, Published online: 10 September 2025; doi:10.1038/s41577-025-01214-wThe actin cytoskeleton is essential for immune cell shape, signalling and function. In this Review, the authors examine how germ-line mutatio…
Nature Reviews Immunology, Published online: 08 September 2025; doi:10.1038/s41577-025-01219-5Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conven…
Nature Reviews Immunology, Published online: 03 September 2025; doi:10.1038/s41577-025-01218-6The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new,…
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus.
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01224-8B cells that expand following infection with EBV can colonize the brain, where they recruit activated T cells that have potential to cause ne…
Nature Reviews Immunology, Published online: 29 August 2025; doi:10.1038/s41577-025-01220-yA study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins.
Nature Reviews Immunology, Published online: 14 August 2025; doi:10.1038/s41577-025-01211-zTumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute …
