An ear way to calm the airways
Nature Reviews Immunology, Published online: 30 July 2026; doi:10.1038/s41577-026-01346-7Stimulating the auricular branch of the vagus nerve can suppress allergic airway inflammation in mice.
Nature Reviews Immunology
How Big Data and AI are revolutionizing human immunology
Nature Reviews Immunology, Published online: 23 July 2026; doi:10.1038/s41577-026-01340-zUnderstanding human biology in health and disease has entered a new era, one defined not just by better tools but by a fundamental shift in how bi…
A lymphatic circuit that sustains antitumour immune surveillance
Nature Reviews Immunology, Published online: 22 July 2026; doi:10.1038/s41577-026-01342-xA preprint by Delclaux et al. reports that dendritic cells recirculate tumour antigen to the draining lymph nodes to re-engage tumour-egressed T c…
Drug holidays restore exhausted T cell responses to PD1 blockade
Nature Reviews Immunology, Published online: 21 July 2026; doi:10.1038/s41577-026-01343-wA preprint by Ngiow et al. shows that intermittent PD1 blockade incorporating a ‘drug holiday’ preserves the proliferative and differentiation cap…
Macrophages are constitutive architects of tissue integrity
Nature Reviews Immunology, Published online: 17 July 2026; doi:10.1038/s41577-026-01334-xThe lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintena…
Interleukin-18 armours antitumour immune effectors
Nature Reviews Immunology, Published online: 16 July 2026; doi:10.1038/s41577-026-01330-1Interleukin-18 (IL-18) shapes tumour immunity through tightly regulated, context-dependent effects on T cells, NK cells and the tumour microenviro…
Programming macrophage polarization with synthetic cytokine receptors
Nature Reviews Immunology, Published online: 14 July 2026; doi:10.1038/s41577-026-01338-7A preprint by Lunger et al. reports macrophage engineering through constitutively active synthetic cytokine receptors to induce polarization state…
The challenge and promise of studying human antigen-specific T cells
Nature Reviews Immunology, Published online: 13 July 2026; doi:10.1038/s41577-026-01331-0Antigen-specific T cells underpin immunity, cancer surveillance and autoimmunity, yet remain difficult to study. This Review describes the technol…
Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis
Nature Reviews Immunology, Published online: 10 July 2026; doi:10.1038/s41577-026-01336-9A study by Tian et al. reports that psychological stress suppresses neuronal activity in brain regions that innervate the gut, leading to intestin…
Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
Nature Reviews Immunology, Published online: 09 July 2026; doi:10.1038/s41577-026-01339-6Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus