Nature Reviews Immunology, Published online: 23 April 2026; doi:10.1038/s41577-026-01291-5What is unique about the immune system of people who live to extreme old age? Here the authors describe that centenarians may achieve such longev…
Nature Reviews Immunology, Published online: 22 April 2026; doi:10.1038/s41577-026-01294-2This Review discusses the diverse lymphocyte responses that occur against Leishmania parasites. In particular, the authors highlight how these im…
Nature Reviews Immunology, Published online: 20 April 2026; doi:10.1038/s41577-026-01296-0Monocytes and macrophages adopt modular programmes in response to cancer cells, which can be viewed as an ‘infectious self’ challenge, and cues f…
Nature Reviews Immunology, Published online: 15 April 2026; doi:10.1038/s41577-026-01292-4This Review discusses how select metabolites and nutrients act as signalling molecules to regulate the functions of tissue-resident macrophages i…
Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The au…
Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01288-0This Review provides an integrated overview of Kupffer cell biology, from their embryonic origin and spatial organization to their functional spe…
Nature Reviews Immunology, Published online: 07 April 2026; doi:10.1038/s41577-026-01302-5In a study in Immunity, Allen et al. show that senescent lung fibroblasts in aged mice promote inflammaging by supporting a pro-inflammatory, age…
Nature Reviews Immunology, Published online: 07 April 2026; doi:10.1038/s41577-026-01301-6Loss of mitochondrial integrity can promote T cell exhaustion through proteasome-mediated release of regulatory haem.
Nature Reviews Immunology, Published online: 07 April 2026; doi:10.1038/s41577-026-01299-xA preprint by Fatima et al. reports that Nr4a1-knockout CD8+ T cells have increased cytotoxicity in a mouse model of active tuberculosis, resulti…
Nature Reviews Immunology, Published online: 02 April 2026; doi:10.1038/s41577-026-01298-yNeutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infecti…
