A TH17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
Science Immunology, Volume 9, Issue 95, May 2024.
Publicaciones
Everlasting first impressions in B cells
Science Immunology, Volume 9, Issue 95, May 2024.
The Benjamin Button effect on stem cells: Reversing the clock on aging immunity
Science Immunology, Volume 9, Issue 95, May 2024.
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
Science Immunology, Volume 9, Issue 95, May 2024.
Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis
Science Immunology, Volume 9, Issue 95, May 2024.
KMT2D regulates activation, localization, and integrin expression by T-cells
Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up on …
Dimethyl fumarate modulates the regulatory T cell response in the mesenteric lymph nodes of mice with experimental autoimmune encephalomyelitis
Dimethyl fumarate (DMF, Tecfidera) is an oral drug utilized to treat relapsing-remitting multiple sclerosis (MS). DMF treatment reduces disease activity in MS. Gastrointestinal discomfort is a common adverse effect of the treatment with DMF. This study…
Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target
IntroductionRecently, we reported that post COVID-19 condition patients also have Transient Receptor Potential Melastatin 3 (TRPM3) ion channel dysfunction, a potential biomarker reported in natural killer (NK) cells from Myalgic Encephalomyelitis/Chro…
Extracellular vesicles in non-small cell lung cancer stemness and clinical applications
Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancers, the leading cause of cancer associated deaths in the US and worldwide. Within NSCLC tumors, there is a subpopulation of cancer cells termed cancer stem cells (CSCs) which exhibit s…
Emerging role of gut microbiota in autoimmune diseases
Accumulating studies have indicated that the gut microbiota plays a pivotal role in the onset of autoimmune diseases by engaging in complex interactions with the host. This review aims to provide a comprehensive overview of the existing literatures con…