Seminars in Immunology

Semin Immunol. 2024 Dec 19;77:101925. doi: 10.1016/j.smim.2024.101925. Online ahead of print. ABSTRACT Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding … Read more

Semin Immunol. 2024 Dec 18;77:101921. doi: 10.1016/j.smim.2024.101921. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, is involved in seemingly contradictory aspects of tumor progression and cancer therapy. It can act as an immune effector against cancer and modulate the antitumor activity of certain therapeutic antibodies, but it can also … Read more

Semin Immunol. 2024 Nov 26;76:101913. doi: 10.1016/j.smim.2024.101913. Online ahead of print. ABSTRACT The immune system is a complex network of highly specialized microenvironments, denominated niches, which arise from dynamic interactions between immune and parenchymal cells as well as acellular components such as structural elements and local molecular signals. A critical, yet underexplored, layer shaping these … Read more

Semin Immunol. 2024 Nov 23;76:101911. doi: 10.1016/j.smim.2024.101911. Online ahead of print. ABSTRACT Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host-virus interaction landscape. This review explores the multifaceted contributions of endogenous galectins to various stages of the viral lifecycle, including attachment, replication, assembly, and release of progeny virions. Recent studies have indicated … Read more

Semin Immunol. 2024 Nov 22;76:101912. doi: 10.1016/j.smim.2024.101912. Online ahead of print. ABSTRACT The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system … Read more

Semin Immunol. 2024 Nov 6;74-75:101901. doi: 10.1016/j.smim.2024.101901. Online ahead of print. ABSTRACT Inborn errors of immunity (IEI) encompass a group of disorders with a strong genetic component. Prompt and accurate diagnosis of these disorders is essential for effective clinical management. Next-generation sequencing (NGS) has significantly enhanced the diagnostic process by offering a comprehensive and scalable … Read more

Semin Immunol. 2024 Oct 25;74-75:101900. doi: 10.1016/j.smim.2024.101900. Online ahead of print. ABSTRACT Dendritic cells (DCs) are crucial for initiating immune responses against tumours by presenting antigens to T cells. Glycosylation, particularly sialylation, plays a significant role in regulating cell functions, by modulating protein folding and signalling. This review aimed to provide a comprehensive overview of … Read more

Semin Immunol. 2024 Oct 19;74-75:101893. doi: 10.1016/j.smim.2024.101893. Online ahead of print. ABSTRACT Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in recent years, providing new and potentially curative options for patients with even advanced disease. However, only a minority of patients achieve long-lasting remissions, and resistance to immune checkpoint inhibition is common. Recently, the … Read more

Semin Immunol. 2024 Oct 14;74-75:101889. doi: 10.1016/j.smim.2024.101889. Online ahead of print. ABSTRACT Hematopoiesis- the formation of blood cell components- continually replenishes the blood system during embryonic development and postnatal lifespans. This coordinated process requires the synchronized action of a broad range of cell surface associated proteins and soluble mediators, including growth factors, cytokines and lectins. … Read more

Semin Immunol. 2024 Oct 14;74-75:101892. doi: 10.1016/j.smim.2024.101892. Online ahead of print. ABSTRACT ABO blood group antigens, which are complex carbohydrate moieties, and the first human polymorphisms identified, are critical in transfusion medicine and transplantation. Despite their discovery over a century ago, significant questions remain about the development of anti-ABO antibodies and the structural features of … Read more