B cell clonality in cancer. E A Bryushkova

Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19. ABSTRACT Carcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature … Read more

Systems biology of B cells in COVID-19. Matthew C Woodruff

Semin Immunol. 2024 Mar;72:101875. doi: 10.1016/j.smim.2024.101875. Epub 2024 Mar 14. ABSTRACT The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. … Read more

Systems analysis of innate and adaptive immunity in Long COVID. Michael J Peluso

Semin Immunol. 2024 Mar;72:101873. doi: 10.1016/j.smim.2024.101873. Epub 2024 Mar 8. ABSTRACT Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the management of Long COVID (LC), an infection-associated chronic condition that has been estimated to affect 5-20% of individuals … Read more

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