Seminars in Immunology

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system. Lucy I Crouch

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Semin Immunol. 2024 Oct 9;73:101891. doi: 10.1016/j.smim.2024.101891. Online ahead of print. ABSTRACT The human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to … Read more

High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions. A Cindrić

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Semin Immunol. 2024 Oct 8;73:101890. doi: 10.1016/j.smim.2024.101890. Online ahead of print. ABSTRACT As the global population ages at an unprecedented rate, the prevalence of age-related diseases is increasing, making inflammaging – a phenomenon characterized by a chronic, low-grade inflammatory state that follows aging – a significant concern. Understanding the mechanisms of inflammaging and its impact … Read more

Siglecs as modulators of macrophage phenotype and function. Emily N Kukan

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Semin Immunol. 2024 Oct 1;73:101887. doi: 10.1016/j.smim.2024.101887. Online ahead of print. ABSTRACT The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors expressed widely on cells of the hematopoietic system. Siglecs recognize terminal sialic acid residues on glycans and often initiate intracellular signaling upon ligation. Cells can express several Siglec family members concurrently with … Read more

Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya

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Semin Immunol. 2024 Mar;72:101864. doi: 10.1016/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor – in distinct cancers, subcohorts and individual patients – is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute … Read more

Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar

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Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016/j.smim.2024.101884. Online ahead of print. ABSTRACT Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune … Read more

Early life microbiome influences on development of the mucosal innate immune system. Aline Ignacio

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Semin Immunol. 2024 May 23;73:101885. doi: 10.1016/j.smim.2024.101885. Online ahead of print. ABSTRACT The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways to maintain host homeostasis. Although the formation of the immune system initiates before birth in a sterile environment, an emerging body of literature indicates that the … Read more

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