J Immunol. 2025 Aug 1:vkaf151. doi: 10.1093/jimmun/vkaf151. Online ahead of print. ABSTRACT CD47 is an antiphagocytic (“don’t eat me”) signal expressed on all cells that inhibits programmed cell removal of self, and loss of this molecule by aging erythrocytes is associated with increased susceptibility to clearance by macrophages. Previously, we have demonstrated that absence of … Read more

J Immunol. 2025 Jul 1;214(7):1439-1440. doi: 10.1093/jimmun/vkaf145. NO ABSTRACT PMID:40740035 | DOI:10.1093/jimmun/vkaf145

J Immunol. 2025 Jul 29:vkaf172. doi: 10.1093/jimmun/vkaf172. Online ahead of print. ABSTRACT As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet, older mice develop insulin resistance more easily than young mice. But how aging renders both humans and mice … Read more

J Immunol. 2025 Jul 28:vkaf153. doi: 10.1093/jimmun/vkaf153. Online ahead of print. ABSTRACT Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we demonstrate that Eomesodermin is a key transcription factor determining the lineage of tissue-resident NK cells within the uterus both at steady state … Read more

J Immunol. 2025 Jul 25:vkaf159. doi: 10.1093/jimmun/vkaf159. Online ahead of print. ABSTRACT In this study, monoclonal antibodies (mAbs) specific for sole immunoglobulin M (IgM) were generated, which allowed us to evaluate the kinetics of IgM+ B cell responses, assess the recruitment of these cells to the peritoneum following vaccination, and compare the dynamics of antigen-specific … Read more

J Immunol. 2025 Jul 26:vkaf143. doi: 10.1093/jimmun/vkaf143. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells recognize conserved microbial antigens presented by the non-polymorphic MR1 molecules and play important roles in barrier immunity. Enterotoxigenic E. coli (ETEC) is a major cause of diarrheal disease in children in lower-income countries and among travelers. Here we … Read more

J Immunol. 2025 Jul 26:vkaf144. doi: 10.1093/jimmun/vkaf144. Online ahead of print. ABSTRACT Infection with influenza virus remains a significant global health concern due to its ability to acquire mutations at key antigenic sites to escape antibody recognition. While germinal center (GC) and memory B cells have been well studied following influenza infection, the clonal dynamics … Read more

J Immunol. 2025 Jul 23:vkaf071. doi: 10.1093/jimmun/vkaf071. Online ahead of print. ABSTRACT Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have reported that a considerable proportion of patients experience deterioration of their disease when glucocorticoids or other immunosuppressants are withdrawn. However, the underlying mechanisms responsible for this … Read more

J Immunol. 2025 Jul 22:vkaf122. doi: 10.1093/jimmun/vkaf122. Online ahead of print. ABSTRACT Cell transfer experiments complement the rigorous investigation of antiviral and antitumor functions of natural killer (NK) cells. Success in these endeavors is enhanced by expansion of small numbers of input NK cells driven by viral antigens or homeostatic proliferation in immunodeficient hosts. In … Read more

J Immunol. 2025 Jul 21:vkaf150. doi: 10.1093/jimmun/vkaf150. Online ahead of print. ABSTRACT Th1 and Th17 cell-mediated autoimmunity is critical for myocarditis induction. Antigen-presenting cell (APCs)-released interleukin (IL)-12 and IL-23 are implicated in the differentiation of Th1 and Th17 lineages. In this study, we utilized cardiac self-antigen myosin heavy chain alpha (α-MyHC)-pulsed bone marrow-derived dendritic cells … Read more