The Journal of Immunology

J Immunol. 2026 May 14;215(5):vkag112. doi: 10.1093/jimmun/vkag112. ABSTRACT Anti-CD19 chimeric antigen receptor (CAR) T cells have emerged as a promising therapeutic strategy for autoimmune diseases, including systemic lupus erythematosus. An unresolved question is how immunosuppressive preconditioning regimens influence CAR-T cell engraftment and therapeutic efficacy. In murine models, whole-body irradiation is required for optimal CAR-T cell … Read more

J Immunol. 2026 May 14;215(5):vkaf296. doi: 10.1093/jimmun/vkaf296. ABSTRACT CD8 cytolytic T cells are key players in fighting viral infections and other intracellular pathogens. In response to signals from the TCR, costimulatory molecules, and cytokines, CD8 T cells differentiate into populations of cytolytic effectors that can efficiently kill infected and tumor cells, as well as memory … Read more

J Immunol. 2026 May 14;215(5):vkag098. doi: 10.1093/jimmun/vkag098. ABSTRACT Coccidioidomycosis is a leading cause of pneumonia in the endemic area of the Sonora desert and the central valley of California. The causative agent are the fungi Coccidioides immitis and C. posadasii. While most infections ultimately resolve without treatment, some infections spread to the periphery and cause … Read more

J Immunol. 2026 May 14;215(5):vkag103. doi: 10.1093/jimmun/vkag103. ABSTRACT NFIL3 (E4BP4) is a basic leucine zipper transcription factor best known for its roles in circadian regulation. It functions primarily as a transcriptional repressor through competitive DNA binding and the recruitment of histone-modifying complexes. More recently, NFIL3 has emerged as a critical regulator of immunity. It is … Read more

J Immunol. 2026 May 14;215(5):vkag066. doi: 10.1093/jimmun/vkag066. ABSTRACT Neutrophils are crucial to innate immune responses to microbes. The engagement of opsonized pathogens by Fc gamma receptors (FcγRs) on neutrophil surfaces mediates multiple antimicrobial functions, including phagocytosis and the production of reactive oxygen species (ROS). FcγRIIIb (CD16b) is the most abundant FcγR on human neutrophils. This … Read more

J Immunol. 2026 May 14;215(5):vkag111. doi: 10.1093/jimmun/vkag111. ABSTRACT The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that occurs spontaneously in the absence of adaptive immunity. … Read more

J Immunol. 2026 May 14;215(5):vkag002. doi: 10.1093/jimmun/vkag002. ABSTRACT Phosphoinositide 3-kinase (PI3K) mediates signaling downstream of many receptors expressed by B cells. Studies in both mice and humans have shown that PI3K plays a critical role in B-cell development, activation, and tolerance. Indeed the key role of PI3K in regulating activation versus tolerance is demonstrated by … Read more

J Immunol. 2026 May 14;215(5):vkag071. doi: 10.1093/jimmun/vkag071. NO ABSTRACT PMID:42153523 | DOI:10.1093/jimmun/vkag071

J Immunol. 2026 May 14;215(5):vkag075. doi: 10.1093/jimmun/vkag075. ABSTRACT Among the PI3K isoforms, PI3Kδ has attracted particular attention from immunologists and hematologists. Despite earlier clinical setbacks, the PI3Kδ field has recently re-emerged with renewed promise. Here, I highlight key milestones in the evolving understanding of PI3Kδ signaling in immunity and cancer, and pivotal studies that have … Read more

J Immunol. 2026 May 14;215(5):vkag085. doi: 10.1093/jimmun/vkag085. ABSTRACT NLRP3 inflammasome activation drives interleukin (IL)-1β and IL-18 cleavage and secretion and induces pyroptosis. The ketone body β-hydroxybutyrate (BHB), produced during metabolic stress such as caloric insufficiency, has been reported to inhibit this pathway. However, the conditions that enable this effect, and whether it extends to other … Read more