J Immunol. 2026 Apr 15;215(4):vkag046. doi: 10.1093/jimmun/vkag046. ABSTRACT Transformed cells frequently adapt to immune pressure by modulating expression of ligands for PD-1 and CTLA-4. Despite the success of therapies targeting these interactions, only a minority of patients experience a clinical response, highlighting the critical need for alternative targets. Prior work from our group showed that … Read more
J Immunol. 2026 Apr 15;215(4):vkag048. doi: 10.1093/jimmun/vkag048. ABSTRACT Immunoglobulin class switch recombination by B lymphocytes requires the simultaneous expression of activation-induced cytidine deaminase (AID) and noncoding germline transcripts (GLT). Expression of both components is controllable through cytokine signalling and arise through stochastic mechanisms linked to cell division that can be predicted in mathematical models. Here … Read more
J Immunol. 2026 Apr 15;215(4):vkaf356. doi: 10.1093/jimmun/vkaf356. NO ABSTRACT PMID:42027188 | DOI:10.1093/jimmun/vkaf356
J Immunol. 2026 Apr 15;215(4):vkag043. doi: 10.1093/jimmun/vkag043. ABSTRACT CD4+ Th1 cells migrate to sites of inflammation, where they are indispensable for eliminating intracellular pathogens. The lineage-defining transcription factor T-bet establishes the T-helper 1 (Th1) transcriptional program, directing IFN-γ to drive effector responses and inducing subordinate transcription factors to shape the Th1 phenotype. Aberrant Th1 cell … Read more
J Immunol. 2026 Apr 15;215(4):vkag045. doi: 10.1093/jimmun/vkag045. ABSTRACT Interleukin 2 (IL-2) is a cytokine secreted by activated T cells that plays a central role in T cell proliferation and differentiation. In this study, we identified MARCH2, an E3 ubiquitin ligase of the MARCH family, as a negative regulator of IL-2 receptor alpha (IL-2Rα). MARCH2 interacts … Read more
J Immunol. 2026 Apr 15;215(4):vkag049. doi: 10.1093/jimmun/vkag049. ABSTRACT Autoimmune disorders reduce quality of life and lifespan and can increase B cell lymphoma risk. The adaptor protein TRAF3 regulates B cell survival, activation, and differentiation by restraining signaling through Toll-like receptors, tumor necrosis factor (TNF) receptor superfamily members, and the B cell antigen receptor-pathways linked to … Read more
J Immunol. 2026 Apr 15;215(4):vkag037. doi: 10.1093/jimmun/vkag037. ABSTRACT Escherichia coli (E. coli) is a leading cause of invasive bacterial infections in humans. Pathogenic E. coli is not only the major etiological agent of enteric/diarrheal disease and urinary tract infections, but also among the most common causes of sepsis and meningitis. Caspase-8 is known to regulate … Read more
J Immunol. 2026 Apr 15;215(4):vkag041. doi: 10.1093/jimmun/vkag041. ABSTRACT Riemerella anatipestifer infection causes septicemia and polyserositis in poultry, leading to serious economic losses to the global poultry industry. The ability to break through the host complement defense barrier is an important characteristic of R. anatipestifer. However, the underlying mechanisms are still not well understood at present. … Read more
J Immunol. 2026 Apr 15;215(4):vkag035. doi: 10.1093/jimmun/vkag035. ABSTRACT The importance of NAD metabolism in T cell differentiation and function has gained attention in recent years. However, technical limitations impede the specific interrogation of NAD dynamics in living immune cells. In this report, we present the redox index and capacity analysis (RICA) assay, a novel technique … Read more
J Immunol. 2026 Apr 15;215(4):vkaf371. doi: 10.1093/jimmun/vkaf371. ABSTRACT The immune environment at the maternal-fetal interface is highly regulated and changes depending on the stage of pregnancy. Any dysregulation or imbalance of the pro- and anti-inflammatory stages can disrupt placental development and can lead to various obstetric disorders, such as miscarriage, preterm birth, and preeclampsia. Several … Read more
