J Immunol. 2025 May 13:vkaf056. doi: 10.1093/jimmun/vkaf056. Online ahead of print. ABSTRACT Leprosy is a neglected chronic infectious disease caused by Mycobacterium leprae or M. lepromatosis, representing a public health concern in several low-income countries. In Brazil, most patients develop lepromatous leprosy, a clinical form characterized by poor bacillary control due to T helper 2 … Read more
J Immunol. 2025 May 13:vkaf064. doi: 10.1093/jimmun/vkaf064. Online ahead of print. ABSTRACT A balanced IFN response, tightly regulated at multiple levels, is essential for host defense against viral infection. Tripartite motif-containing (TRIM) proteins are a large group of E3 ubiquitin ligases, and have been shown to be involved in the regulation of IFN response. However, … Read more
J Immunol. 2025 May 13:vkaf083. doi: 10.1093/jimmun/vkaf083. Online ahead of print. ABSTRACT TCRγδ+ T cells are a major lymphocyte population of chickens, but their response or contribution to immunity against avian influenza virus (AIV) remains unknown. Here, we report an increase in the proportion and activation state of TCRγδ+CD8α+ T cells in the PBMCs of … Read more
J Immunol. 2025 May 12:vkaf113. doi: 10.1093/jimmun/vkaf113. Online ahead of print. NO ABSTRACT PMID:40356078 | DOI:10.1093/jimmun/vkaf113
J Immunol. 2025 May 12:vkaf078. doi: 10.1093/jimmun/vkaf078. Online ahead of print. ABSTRACT Alcohol use disorder increases sepsis mortality. Acute ethanol exposure impairs pathogen clearance in the macrophages via dampened glycolysis and phagocytosis, exaggerates oxidative stress, and regulates the function of the hypoxia-regulating factor 1α (HIF-1α), a master regulator of glycolysis. Decreased expression of the platelet … Read more
J Immunol. 2025 May 12:vkaf065. doi: 10.1093/jimmun/vkaf065. Online ahead of print. ABSTRACT Factor H controls proximal complement activation, and its dysfunction leads to diseases that often manifest in the kidney. Structural and functional analyses have identified 4 distinct functional segments: an N-terminal regulatory unit, a cell binding unit, a segment with combined low-affinity C3b and … Read more
J Immunol. 2025 May 9:vkaf055. doi: 10.1093/jimmun/vkaf055. Online ahead of print. ABSTRACT The current array of traditional antibacterial agents targeting Gram-negative infections are failing to meet the clinical need. Here we present a novel, bifunctional immunotherapy (CTX-09) with the ability to harness endogenous anti-galactose-alpha-1,3-galactosyl-beta-1,4-N-acetyl-glucosamine (anti-αGal) antibodies to drive immune-mediated clearance of Gram-negative bacteria. In addition, … Read more
J Immunol. 2025 May 8:vkaf079. doi: 10.1093/jimmun/vkaf079. Online ahead of print. ABSTRACT The Phase 2 IMPRIME 1 study evaluated the combination of the pathogen-associated molecular pattern (PAMP) Imprime with the immune checkpoint inhibitor (ICI) pembrolizumab as second or later line of treatment (2 L+) for patients with metastatic triple-negative breast cancer (mTNBC). Eligible patients with … Read more
J Immunol. 2025 May 7:vkaf088. doi: 10.1093/jimmun/vkaf088. Online ahead of print. ABSTRACT Pulmonary type 2 innate lymphoid cells (ILC2s) exhibit immune memory, termed “trained immunity,” which enhances their activation following exposure to an independent protease-containing allergen. The role of prostaglandin I2 (PGI2), a cyclooxygenase (COX) pathway metabolite, in modulating these trained ILC2 responses remains unclear. … Read more
J Immunol. 2025 May 7:vkaf085. doi: 10.1093/jimmun/vkaf085. Online ahead of print. ABSTRACT Disease-modifying therapies (DMTs) are critical for managing autoimmunity such as multiple sclerosis (MS), yet concerns exist regarding their impact on viral infections. B-cell depletion (α-CD20) and IFN-β are 2 DMTs with seemingly opposing effects on viral infections. Pre-vaccine COVID-19 data linked B-cell depletion … Read more
