J Immunol. 2025 Nov 25:vkaf323. doi: 10.1093/jimmun/vkaf323. Online ahead of print. ABSTRACT Janus kinase 2 (JAK2) has been linked to various neutrophil functions, but the intracellular mechanisms underlying its modulation are unknown. Neutrophils are essential cells for host defense. Neutrophil effector functions include migration, neutrophil extracellular trap production (NETosis), reactive oxygen species (ROS) production, and … Read more

J Immunol. 2025 Nov 25:vkaf320. doi: 10.1093/jimmun/vkaf320. Online ahead of print. ABSTRACT Organ transplantation is a life-saving treatment for patients with end-stage organ failure but requires lifelong immunosuppression that can result in significant complications. Achieving stable and durable donor-specific tolerance, whereby immunosuppression can be stopped without precipitating graft rejection, holds the promise to circumvent these … Read more

J Immunol. 2025 Nov 22:vkaf316. doi: 10.1093/jimmun/vkaf316. Online ahead of print. ABSTRACT The extracellular fibrinogen-binding protein (Efb) is one of nearly a dozen proteins secreted by Staphylococcus aureus to inhibit complement activation or amplification. The C-terminal domain of Efb (Efb-C) forms a high-affinity interaction with the thioester-containing domain of C3b (TED/C3d), thereby blocking formation of … Read more

J Immunol. 2025 Nov 20:vkaf312. doi: 10.1093/jimmun/vkaf312. Online ahead of print. ABSTRACT Peptide-based therapeutic vaccines exploit cross-presentation by dendritic cells for the induction of effective T cell responses. Their clinical success, however, has been limited due to incomplete understanding of antigen processing and presentation (APP). Bioorthogonal chemistry (BOC) uses chemical “click” reactions that can be … Read more

J Immunol. 2025 Nov 20:vkaf294. doi: 10.1093/jimmun/vkaf294. Online ahead of print. ABSTRACT The Mycobacterium tuberculosis complex (MTBC), comprising species such as M. tuberculosis, M. africanum, and M. canettii, is the causative agent of tuberculosis (TB), one of the deadliest infectious diseases worldwide. MTBC strains exhibit genetic diversity that influences host-pathogen interactions, immune evasion, and disease … Read more

J Immunol. 2025 Nov 18:vkaf314. doi: 10.1093/jimmun/vkaf314. Online ahead of print. ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapy including immune checkpoint blockade (ICB). We previously showed that ICB selects for pancreatic tumor cells that are defective in IFN-γ-inducible MHC-I, prompting us to test the impact of IL-15 complex (IL-15C) in … Read more

J Immunol. 2025 Nov 16:vkaf287. doi: 10.1093/jimmun/vkaf287. Online ahead of print. ABSTRACT Assigning antigen specificity to T cell receptor (TCR) sequences is challenging due to the TCR repertoire’s diversity and the complexity of TCR-antigen recognition. We developed the peptide-driven identification of TCRs (PDI-TCR) assay that combines in vitro expansion of cells with peptide pools, bulk … Read more

J Immunol. 2025 Nov 15:vkaf311. doi: 10.1093/jimmun/vkaf311. Online ahead of print. ABSTRACT Interferon regulatory factors 3 and 7 (IRF3 and IRF7, respectively), which serve as key transcription factors in interferon (IFN) activation, are tightly regulated by a variety of mechanisms, including multiple posttranslational modifications, to fulfill their normal physiological functions. Nevertheless, the methylation-mediated regulation of … Read more

J Immunol. 2025 Nov 15:vkaf146. doi: 10.1093/jimmun/vkaf146. Online ahead of print. ABSTRACT Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that employs several strategies to evade the host immune system to establish a favorable niche inside the macrophages. One of the major immune evasion strategies involves induction of T helper 2 (Th2)-type response, which in turn … Read more

J Immunol. 2025 Nov 13:vkaf299. doi: 10.1093/jimmun/vkaf299. Online ahead of print. ABSTRACT Memory stem CD8+ T cells (TSCM) are a long-lived T-cell subset with stem cell-like properties, playing a key role in antiviral immunity. Despite their importance, comprehensive single-cell transcriptomic profiling of antigen-specific TSCM has not been previously conducted. In this study, an in vitro … Read more