J Immunol. 2025 Apr 2:vkaf039. doi: 10.1093/jimmun/vkaf039. Online ahead of print. ABSTRACT Murine cytomegalovirus (MCMV) respiratory dissemination schemes, which mimic natural infection routes, have only recently become an area of investigation. Using an intratracheal (i.t.) infection method, we discovered that the respiratory infection route yields differential infection kinetics compared to the widely used intraperitoneal (i.p.) … Read more

J Immunol. 2025 Apr 1:vkaf017. doi: 10.1093/jimmun/vkaf017. Online ahead of print. ABSTRACT Follicular dendritic cells (FDCs) retain Ag-containing immune complexes (ICs), facilitate the selection of high-affinity antibodies, and protect B cells in germinal centers (GCs) from apoptosis. In systemic lupus erythematosus patients, apoptotic debris is found on the surface of FDCs. However, the mechanisms by … Read more

J Immunol. 2025 Apr 1:vkaf007. doi: 10.1093/jimmun/vkaf007. Online ahead of print. ABSTRACT Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for evaluating a host’s ability to respond to different kinds of infections and/or immunizations. To track CD8 T-cell responses during infection, a surrogate-activation-marker approach … Read more

J Immunol. 2025 Mar 31:vkae059. doi: 10.1093/jimmun/vkae059. Online ahead of print. ABSTRACT Active immune suppression can mediate the balance between protective cellular immunity and harmful immunopathology. This suppression can occur locally, at an infection site, or in regional draining lymph nodes (dLNs). Immune regulation is of particular importance in sites such as the lung where … Read more

J Immunol. 2025 Mar 12:vkae020. doi: 10.1093/jimmun/vkae020. Online ahead of print. ABSTRACT Autoimmune disease refers to a condition when the immune system anomalously attacks its own body and healthy cells. Although the exact causes of autoimmune diseases are unknown, it is recognized that excessive or aberrant cytokine responses contribute significantly to the development of autoimmunity. … Read more

J Immunol. 2025 Mar 28:vkaf027. doi: 10.1093/jimmun/vkaf027. Online ahead of print. ABSTRACT Macrophages and natural killer (NK) cells can effectively kill tumor cells in the presence of anti-cancer IgG monoclonal antibodies (mAbs), but neutrophils are less effective. We previously showed that IgG1 bispecific antibodies (BsAb), which target the IgA Fc receptor (FcαRI, CD89) and a … Read more

J Immunol. 2025 Mar 28:vkaf038. doi: 10.1093/jimmun/vkaf038. Online ahead of print. ABSTRACT Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cells are cholesterol-laden derives from atherosclerosis research. We previously showed that, in tuberculosis, foam cells surprisingly accumulate triglycerides. Here, we utilized bacterial (Mycobacterium tuberculosis), fungal … Read more

J Immunol. 2025 Mar 27:vkaf013. doi: 10.1093/jimmun/vkaf013. Online ahead of print. ABSTRACT Peptide presentation by major histocompatibility complex (MHC) class I molecules enables CD8+ T lymphocytes to monitor the intracellular proteome of tissue cells. CD8+ T cell priming and acquisition of effector functions is affected by cognate peptide-MHC-I complex density on the cell surface, which … Read more

J Immunol. 2025 Mar 27:vkaf026. doi: 10.1093/jimmun/vkaf026. Online ahead of print. ABSTRACT Increased myeloid lineage production, termed myeloid skewing, leading to decreased tumor immunity, is a hallmark of aberrant hematopoiesis associated with cancer. It is believed that myeloid skewing may occur at the hematopoietic stem and progenitor cells (HSPCs) level to elicit hematopoietic changes. However, … Read more

J Immunol. 2025 Mar 26:vkaf011. doi: 10.1093/jimmun/vkaf011. Online ahead of print. ABSTRACT The Hippo signaling pathway plays an important role in regulating host immune responses. However, few studies have explored its role in fish. Therefore, this study aimed to investigate the mechanism by which the Hippo pathway regulates the expression of antimicrobial peptides (AMPs) in … Read more