J Immunol. 2025 Mar 20:vkae065. doi: 10.1093/jimmun/vkae065. Online ahead of print. ABSTRACT Endometrial stromal cells acquire a secretory profile associated with endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) related to the onset of a sterile inflammatory response essential for sustaining embryo implantation. However, exacerbated stromal ERS/UPR is associated with reproductive complications. Given the … Read more

J Immunol. 2025 Mar 20:vkaf021. doi: 10.1093/jimmun/vkaf021. Online ahead of print. ABSTRACT Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse line in which downstream of the coding … Read more

J Immunol. 2025 Mar 19:vkae064. doi: 10.1093/jimmun/vkae064. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. Here, we show that IL-33R (ST2)-expressing Tregs … Read more

J Immunol. 2025 Mar 19:vkaf025. doi: 10.1093/jimmun/vkaf025. Online ahead of print. NO ABSTRACT PMID:40107285 | DOI:10.1093/jimmun/vkaf025

J Immunol. 2025 Mar 18:vkae055. doi: 10.1093/jimmun/vkae055. Online ahead of print. ABSTRACT Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA-based drugs that hold great therapeutic potential. A low incidence of severe, dose-dependent, and reversible thrombocytopenia (TCP) (platelets < 50 K/μl) has been reported in nonhuman primate (NHP) populations, following treatment of monkeys with … Read more

J Immunol. 2025 Mar 18:vkae061. doi: 10.1093/jimmun/vkae061. Online ahead of print. ABSTRACT Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range … Read more

J Immunol. 2025 Mar 18:vkae053. doi: 10.1093/jimmun/vkae053. Online ahead of print. ABSTRACT Respiratory viral infections are a major contributor to mortality in children under 5 years of age, and disproportionately affect preterm neonates. Previously, using our established 3-day-old neonatal murine model of influenza virus infection, we demonstrated that treatment of neonatal mice with intranasal Lactobacillus … Read more

J Immunol. 2025 Mar 18:vkaf006. doi: 10.1093/jimmun/vkaf006. Online ahead of print. ABSTRACT Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To investigate innate immune functions, we stimulated ex vivo peripheral blood cells from … Read more

J Immunol. 2025 Mar 17:vkae047. doi: 10.1093/jimmun/vkae047. Online ahead of print. ABSTRACT Killer cell immunoglobulin-like receptors (KIRs) are key modulators of natural killer cell activity, displaying either activating or inhibitory potential upon recognition of major histocompatibility complex (MHC) class I molecules. The genomic organization of KIR genes is complex, involving copy number variation and allelic … Read more

J Immunol. 2025 Mar 17:vkae045. doi: 10.1093/jimmun/vkae045. Online ahead of print. ABSTRACT The cytokine IL-2 plays a pivotal role in the immune system, specifically in the proliferation of T, B, and NK cells. The alpha subunit of the IL-2 receptor, IL-2Rα (CD25), is known to regulate the expansion and differentiation of T lymphocytes. CD25 is … Read more