The Journal of Immunology

J Immunol. 2025 Oct 1;214(10):2504-2514. doi: 10.1093/jimmun/vkaf231. ABSTRACT Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic model of hepatitis type B that, like in humans, can advance stepwise from acute hepatitis to chronic hepatitis and hepatocellular carcinoma (HCC) or become self-resolving and persist as a … Read more

J Immunol. 2025 Oct 1;214(10):2489-2491. doi: 10.1093/jimmun/vkaf163. NO ABSTRACT PMID:41169233 | DOI:10.1093/jimmun/vkaf163

J Immunol. 2025 Oct 1;214(10):2535-2542. doi: 10.1093/jimmun/vkaf236. ABSTRACT While rodent models remain foundational in biomedical research for their manipulability, genetics, and reproducibility, spontaneous diseases in companion animals provide relevant models to study naturally occurring conditions. Pathogenic processes underlying diseases in humans and dogs are similar or identical, which exemplifies the One Health concept. Companion animals … Read more

J Immunol. 2025 Oct 1;214(10):2492-2493. doi: 10.1093/jimmun/vkaf238. NO ABSTRACT PMID:41169231 | DOI:10.1093/jimmun/vkaf238

J Immunol. 2025 Oct 30:vkaf276. doi: 10.1093/jimmun/vkaf276. Online ahead of print. ABSTRACT Influenza is a significant public health and economic threat around the world. Although pneumonia is the most common complication associated with influenza, there are several clinical reports showing an increased risk for cardiovascular disease. Studies have shown that influenza infection correlates with increased … Read more

J Immunol. 2025 Oct 30:vkaf263. doi: 10.1093/jimmun/vkaf263. Online ahead of print. ABSTRACT The National Institutes of Health-funded IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort) evaluated longitudinal clinical and immunological features of human patients hospitalized for COVID-19. This study focuses on comparing the novel NULISAseq assay with the Olink platform using a subset of participants to … Read more

J Immunol. 2025 Oct 30:vkaf286. doi: 10.1093/jimmun/vkaf286. Online ahead of print. ABSTRACT The efficacy of seasonal influenza vaccines varies across age groups, even in individuals with strong antibody responses. Since protection against influenza virus infection also involves cellular immunity, identifying immune markers beyond neutralizing antibodies is crucial for informing the design of next-generation vaccines. Participants … Read more

J Immunol. 2025 Oct 30:vkaf271. doi: 10.1093/jimmun/vkaf271. Online ahead of print. ABSTRACT Septic peritonitis (SP) is a severe infectious complication associated with high morbidity and mortality. The role of microRNAs, particularly endothelial progenitor cell-derived exosomal miRNA-31 (EPC-ExosmiR-31), in modulating inflammatory pathways in SP has garnered scholars’ attention. However, its precise role and mechanism of action … Read more

J Immunol. 2025 Oct 29:vkaf277. doi: 10.1093/jimmun/vkaf277. Online ahead of print. ABSTRACT PTEN-induced kinase 1 (PINK1)-mediated mitophagy, a classic mechanism underlying the elimination of damaged mitochondria, plays a crucial role in the immune evasion of bacteria. In the present study, we found that Edwardsiella piscicida, an intracellular pathogenic bacterium that infects fish, could induce PINK1-mediated … Read more

J Immunol. 2025 Oct 29:vkaf258. doi: 10.1093/jimmun/vkaf258. Online ahead of print. ABSTRACT Endosomal toll-like receptors TLR7 and TLR8 are critical sensors of microbial RNA that initiate antiviral and antibacterial immune responses through type I interferon (IFN) and proinflammatory cytokine production. While TIRAP is traditionally associated with plasma membrane TLR signaling, recent evidence suggests that it … Read more