The Journal of Immunology

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution

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J Immunol. 2025 Jan 1;214(1):85-103. doi: 10.1093/jimmun/vkae010. ABSTRACT Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function and polarization, which is crucial to the resolution of inflammation. The contribution of lipid synthesis to proinflammatory macrophage responses is well understood. However, how lipid synthesis regulates … Read more

Plasmacytoid dendritic cell sensing of African swine fever virus-infected macrophages results in STING-dependent robust interferon-α production

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J Immunol. 2025 Jan 1;214(1):130-140. doi: 10.1093/jimmun/vkae008. ABSTRACT While several African swine fever virus (ASFV)-encoded proteins potently interfere with the cGAS-STING (cyclic GMP-AMP synthetase-stimulator of interferon genes) pathway at different levels to suppress interferon (IFN) type I production in infected macrophages, systemic IFN-α is induced during the early stages of AFSV infection in pigs. The … Read more

Precise motif and cross-presentation of coronavirus peptides by feline MHC class I: implications for the mild infection of SARS-CoV-2

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J Immunol. 2025 Jan 1;214(1):115-129. doi: 10.1093/jimmun/vkae006. ABSTRACT As one of the earliest identified susceptible animals for the SARS-CoV-2, cats are also the vulnerable hosts for feline coronaviruses, ie feline enteric coronavirus (FECV). Here, to understand the cross-presentation of coronavirus-derived peptides by cat major histocompatibility complex molecule feline leucocyte antigen (FLA) class I, unpredictable natural … Read more

Suppression of NF-κB and downstream XBP1 by DcR3 contributes to a decrease in antibody secretion

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J Immunol. 2025 Jan 1;214(1):72-84. doi: 10.1093/jimmun/vkae005. ABSTRACT Decoy receptor 3 (DcR3), a soluble receptor in the tumor necrosis factor receptor superfamily, regulates the functions of monocytes, macrophages, dendritic cells, and T cells. Previous studies have demonstrated that DcR3 suppresses B cell proliferation in vitro and ameliorates autoimmune diseases in animal models; however, whether and … Read more

PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR

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J Immunol. 2025 Jan 1;214(1):55-71. doi: 10.1093/jimmun/vkae002. ABSTRACT Poliovirus receptor (PVR) ligands have gained attention as immunotherapy targets, yet their regulation remains unclear. Here, we examine the impact of PVR exposure on primary human CD8+ T cells. We used flow cytometry and Western blot analysis to quantify expression of PVR and its ligands in naïve … Read more

Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity

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J Immunol. 2025 Jan 1;214(1):180-191. doi: 10.1093/jimmun/vkae022. Epub 2025 Jan 28. ABSTRACT Interleukin (IL)-18 is an immunoregulatory cytokine that acts as a potent inducer of T helper 1 and cytotoxic responses. IL-18 activity is regulated by its decoy receptor IL-18 binding protein (IL-18BP) which forms a high affinity complex with IL-18 to block binding of … Read more

Topoisomerase 1 is required for the development and function of thymus

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J Immunol. 2025 Jan 1;214(1):23-39. doi: 10.1093/jimmun/vkae003. Epub 2025 Jan 23. ABSTRACT Thymus organogenesis is critical for proper maturation of developing T cells. In this study, we identified Topoisomerase 1 (Top1) as a novel gene involved in thymus development and function. We created a mouse line with deletion of Top1 in thymic epithelial cells (TECs) … Read more

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