J Immunol. 2025 Oct 16:vkaf281. doi: 10.1093/jimmun/vkaf281. Online ahead of print. ABSTRACT DDX3 and other DEAD-box RNA helicases regulate nuclear export, translation, splicing, and metabolism of RNA. Perturbation of Ddx3x on the mouse X-chromosome in all hematopoietic cells resulted in a loss of natural killer (NK) cells, yet whether DDX3X is important only in progenitors … Read more
J Immunol. 2025 Oct 16:vkaf278. doi: 10.1093/jimmun/vkaf278. Online ahead of print. ABSTRACT Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. … Read more
J Immunol. 2025 Oct 14:vkaf225. doi: 10.1093/jimmun/vkaf225. Online ahead of print. ABSTRACT Impaired phagocytosis of macrophages was observed in the salivary glands (SGs) of Sjogren’s syndrome (SS). This study aims to investigate the dynamic changes of extracellular high mobility group box 1 (HMGB1) within these tissue microenvironments and its roles in macrophage function and subsequent … Read more
J Immunol. 2025 Oct 15:vkaf158. doi: 10.1093/jimmun/vkaf158. Online ahead of print. ABSTRACT Pinctada fucata martensii is an economically important mollusk in aquaculture, known for marine pearl production. The inflammatory response during the transplantation process was a key factor affecting pearl yield. Our previous studies have revealed the critical role of nicotinic acetylcholine receptors (nAChRs) from … Read more
J Immunol. 2025 Oct 13:vkaf282. doi: 10.1093/jimmun/vkaf282. Online ahead of print. ABSTRACT B cells have been shown to be phagocytic under some circumstances. However, the phagocytic capacity of different B-cell subsets and how this is linked to antigen (Ag) presentation or other functions has not been characterized. To address this, we developed 2-µm phagocytic Ag-conjugated … Read more
J Immunol. 2025 Oct 12:vkaf249. doi: 10.1093/jimmun/vkaf249. Online ahead of print. ABSTRACT Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin inflammation and identified a surprising type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor … Read more
J Immunol. 2025 Oct 10:vkaf268. doi: 10.1093/jimmun/vkaf268. Online ahead of print. ABSTRACT Tuberculosis (TB) is a major global health threat. Deep knowledge of the immune responses against Mycobacterium tuberculosis (Mtb) is crucial for developing effective interventions. Data support that both innate and adaptive CD8+ lymphocytes contribute to protective immunity in Mtb infections, commonly attributed to … Read more
J Immunol. 2025 Oct 10:vkaf214. doi: 10.1093/jimmun/vkaf214. Online ahead of print. ABSTRACT Memory CD8+ T cells are essential for long-term protective immunity. Here, we show that activation of p38 MAPK during the primary response of CD8+ T cells orchestrates a delicate balance between the formation of short-lived effector cells and memory precursor effector cells. p38αfl/flp38βfl/flGzmBcre/- … Read more
J Immunol. 2025 Oct 10:vkaf272. doi: 10.1093/jimmun/vkaf272. Online ahead of print. ABSTRACT Sepsis followed by multiple organ failure is a leading cause of death in noncoronary intensive care units. While the NLRC4 inflammasome has been shown to play a crucial role in the innate immune response, the role of NLRC4 in sepsis remains unclear. Here, … Read more
J Immunol. 2025 Oct 8:vkaf123. doi: 10.1093/jimmun/vkaf123. Online ahead of print. ABSTRACT Vaccination strategies and correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly focused on the spike (S) protein and neutralizing antibodies. However, the rapid emergence of SARS-CoV-2 variants has reduced the effectiveness of spike-based vaccines and monoclonal antibodies. It … Read more
