J Immunol. 2024 Nov 4:ji2400042. doi: 10.4049/jimmunol.2400042. Online ahead of print. ABSTRACT ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host’s defense mechanism against viruses, contributing to the antiviral state of cells. However, altered ISG15 expression can also lead to immune dysregulation … Read more

J Immunol. 2024 Nov 1:ji2400322. doi: 10.4049/jimmunol.2400322. Online ahead of print. ABSTRACT Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility to secondary bacterial infection is the modulation of inflammatory cytokines. NF erythroid 2-related factor 2 (Nrf2) has been … Read more

J Immunol. 2024 Nov 1:ji2400129. doi: 10.4049/jimmunol.2400129. Online ahead of print. ABSTRACT Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how … Read more

J Immunol. 2024 Oct 30:ji2400363. doi: 10.4049/jimmunol.2400363. Online ahead of print. ABSTRACT The increased susceptibility of infants and young children to some diseases has often been explained as the neonatal immune system (NIS) being incomplete and/or underdeveloped. However, our recent work demonstrated that neonatal mice could clear a Bordetella pertussis (Bp) strain lacking pertussis toxin … Read more

J Immunol. 2024 Oct 30:ji2400227. doi: 10.4049/jimmunol.2400227. Online ahead of print. ABSTRACT IFN-β is a potent antiviral cytokine and the first member of the type I IFN family of cytokines to be induced during the antiviral response. IFN-β plays an essential protective role in host defense against virus infections, as well as a pathogenic role … Read more

J Immunol. 2024 Oct 28:ji2400332. doi: 10.4049/jimmunol.2400332. Online ahead of print. ABSTRACT Chronic inflammatory diseases are a leading global health problem. In many of these diseases, the consistent presence of systemic low-grade inflammation induces tissue damage. This is true in conditions such as diabetes, arthritis, and autoimmune disorders, where an overactive and uncontrolled host immune … Read more

J Immunol. 2024 Oct 28:ji2400259. doi: 10.4049/jimmunol.2400259. Online ahead of print. ABSTRACT Eosinophils control many aspects of the vertebrate innate immune response. They contribute to homeostasis, inflammatory conditions and defense against pathogens. With the varied functions of eosinophils, they have been found to play both protective and pathogenic roles in many diseases. The zebrafish (Danio … Read more

J Immunol. 2024 Oct 28:ji2400323. doi: 10.4049/jimmunol.2400323. Online ahead of print. ABSTRACT IL-33 plays an important role in the early programming of CD8 T cells; however, its contribution to the differentiation of tissue-resident memory T cells in vivo remains poorly defined. After infection of mice with Yersinia pseudotuberculosis, IL-33 expression was increased in the intestinal … Read more

J Immunol. 2024 Oct 28:ji2400466. doi: 10.4049/jimmunol.2400466. Online ahead of print. ABSTRACT Defining the MHC class I ligands of rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to NK cell biology in this species as a model for infectious diseases and comparative immunogenetics. Several rhesus macaque KIRs belong to a phylogenetically distinct group with … Read more

J Immunol. 2024 Oct 25:ji2300575. doi: 10.4049/jimmunol.2300575. Online ahead of print. ABSTRACT The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn/J [µMT] + 20% B6.129S2-Irf1tm1Mak/J [Irf1-/-]), we show that IRF1 expression in B cells is … Read more