Correction to: Neonatal Neutrophil-mediated Control of Bordetella pertussis Is Disrupted by Pertussis Toxin
J Immunol. 2025 Sep 22:vkaf255. doi: 10.1093/jimmun/vkaf255. Online ahead of print. NO ABSTRACT PMID:40981765 | DOI:10.1093/jimmun/vkaf255
The Journal of Immunology
Dimethyl itaconate attenuates IL-1-induced IVIG-resistant inflammation in a coronary artery cell model of Kawasaki disease
J Immunol. 2025 Sep 16:vkaf245. doi: 10.1093/jimmun/vkaf245. Online ahead of print. ABSTRACT Kawasaki disease (KD) is the most common childhood vasculitis. Approximately 25% of KD patients are refractory to standard intravenous immunoglobulin (IVIG) therapy and frequently develop coronary artery lesions (CAL) that result in long-term complications. Transcriptome studies utilizing blood cells from KD patients and … Read more
Development of a murine tumor-infiltrating lymphocyte therapy model for cholangiocarcinoma
J Immunol. 2025 Sep 16:vkaf242. doi: 10.1093/jimmun/vkaf242. Online ahead of print. ABSTRACT Tumor-infiltrating lymphocyte (TIL) therapy is a promising approach, earning U.S. Food and Drug Administration approval in patients with anti-PD-1-resistant melanoma. Extending TIL therapy to patients with cholangiocarcinoma (CCA), an aggressive and largely immune-refractory cancer, is an emerging area of interest. However, cost and … Read more
DOT1L-mediated H3K79me2 directs B-cell repertoire establishment, marginal zone development, and germinal center function
J Immunol. 2025 Sep 16:vkaf243. doi: 10.1093/jimmun/vkaf243. Online ahead of print. ABSTRACT Disruptor of telomeric silencing 1-like (DOT1L) is an epigenetic regulator that promotes gene expression by methylating lysine 79 on histone H3 and recruits transcription factors to gene targets. DOT1L is also an oncogenic driver in cancers that affect developing lymphocytes, yet how DOT1L … Read more
Non-hematopoietic tryptophan metabolism is a driver of ineffective T cell responses during secondary pulmonary bacterial infection
J Immunol. 2025 Sep 16:vkaf197. doi: 10.1093/jimmun/vkaf197. Online ahead of print. ABSTRACT Pulmonary infections often fail to produce long-lived immune memory and the underlying mechanism(s) for this are unclear. Given the complex interactions between cells within the lung, we predicted intrinsic and extrinsic factors contribute to development of poor memory immune responses. To identify these … Read more
Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progression
J Immunol. 2025 Sep 16:vkaf253. doi: 10.1093/jimmun/vkaf253. Online ahead of print. ABSTRACT The tumor microenvironment (TME) plays a pivotal role in shaping immune responses and therapeutic outcomes in lung cancer, yet the diversity and functional specialization of tumor-associated macrophages (TAMs) remain poorly resolved. Here, we present a refined classification of TAM subtypes across large cohorts … Read more
Dysregulation of complement components associated with inflammation and coagulation in virally suppressed people living with HIV
J Immunol. 2025 Sep 15:vkaf227. doi: 10.1093/jimmun/vkaf227. Online ahead of print. ABSTRACT Although the interplay between the complement system, platelets, and neutrophils has been considered a major contributor to inflammation and thrombogenicity, little attention has been directed toward understanding their roles in people living with human immunodeficiency virus (PLWH). We quantified and compared expression levels … Read more
Platelet-like anucleate cell fragments mediate wound healing and immune response in the sea star Patiria pectinifera
J Immunol. 2025 Sep 15:vkaf246. doi: 10.1093/jimmun/vkaf246. Online ahead of print. ABSTRACT Blood coagulation and immune responses have long been considered as discrete processes. However, recent studies have revealed that mammalian platelets play a critical role in immune regulation in addition to their well-established role in hemostasis. This dual functionality suggests an evolutionary link between … Read more
Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection
J Immunol. 2025 Sep 15:vkaf200. doi: 10.1093/jimmun/vkaf200. Online ahead of print. ABSTRACT The intestinal mucosa in individuals with chronic human immunodeficiency virus (HIV) infection remains a site of viral persistence and immune dysregulation, even with prolonged suppressive antiretroviral therapy (ART). While biomarkers of mucosal damage and microbial translocation offer valuable correlative insights, the underlying mechanisms … Read more
Knee osteoarthritis (OA)-related phenotypes of myeloid-derived suppressor cells (MDSCs) is mediated by infrapatellar fat pat (IPFP)-derived factors in a body mass index (BMI)-dependent manner and positively correlates with IPFP-derived adiponectin levels
J Immunol. 2025 Sep 15:vkaf213. doi: 10.1093/jimmun/vkaf213. Online ahead of print. ABSTRACT Osteoarthritis (OA) is characterized by cartilage destruction and immune cell infiltration, of which include myeloid-derived suppressor cells (MDSCs). MDSCs have been shown to expand in obese patients with OA. Therefore, we aimed to investigate the role of obesity on MDSC function in knee … Read more